Ty E. Adams
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View article: Rapid and ordered cleavage of prothrombin by Hopsarin D in the absence of phospholipid membranes
Rapid and ordered cleavage of prothrombin by Hopsarin D in the absence of phospholipid membranes Open
Background: Thrombin is produced by the prothrombinase complex, composed of factor (f) Xa and fVa on a phospholipid (PL) membrane surface. Snakes of the Elapidae family have venom versions of these factors that cause coagulopathy in prey. …
View article: Fluorescent Activity-Based Probe To Image and Inhibit Factor XIa Activity in Human Plasma
Fluorescent Activity-Based Probe To Image and Inhibit Factor XIa Activity in Human Plasma Open
Anticoagulation therapy is a mainstay of the treatment of thrombotic disorders; however, conventional anticoagulants trade antithrombotic benefits for bleeding risk. Factor (f) XI deficiency, known as hemophilia C, rarely causes spontaneou…
View article: Parallel imaging of coagulation pathway proteases activated protein C, thrombin, and factor Xa in human plasma
Parallel imaging of coagulation pathway proteases activated protein C, thrombin, and factor Xa in human plasma Open
Using a collection of natural and unnatural amino acids, we synthesized a set of fluorescent activity-based probes for the fast, direct, and simultaneous detection of coagulation factors in human plasma.
View article: Design and characterization of an APC-specific serpin for the treatment of hemophilia
Design and characterization of an APC-specific serpin for the treatment of hemophilia Open
Key Points The endogenous inhibitors of APC also inhibit other coagulation proteases rendering them unacceptable for treatment of hemophilia. Rationally designed APC-specific serpins rescue thrombin generation in vitro and restore hemostas…