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Supplementary Table S2 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Antibodies and materials.

Supplementary Figure S7 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Fig. S7. Intratumoural CD103+CD56+Lin- ILCs displayed unique profile of transcription factors.

Supplementary Figure S8 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Fig. S8. CD56+ ILCs cluster 0 from CITE-seq are composed of predominately CD103+CD49a+ expressing cells.

Supplementary Figure S9 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Fig. S9. CD103+CD56+Lin- ILCs express distinct signatures compared to other ILC subsets.

Supplementary Figure S5 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Fig. S5. Identifying cellular clusters from scRNA-seq of ovarian tumours.

Supplementary Table S8 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

DEGs of CD8+ T cells from tumours with a high proportion, compared to a low proportion, of CD103+CD56+ ILCs.

Supplementary Figure S10 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Fig. S10. CD103+Lin- ILC1-like cells are associated with altered immune landscape within the TME.

Supplementary Table S1 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Patient characteristics.

Data from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Immunotherapies have had unprecedented success in the treatment of multiple cancer types, albeit with variable response rates. Unraveling the complex network of immune cells within the tumor microenvironment (TME) may provide additional in…

Supplementary Table 6 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

DEGs that characterized cell clusters from scRNA-seq and CITE-seq datasets.

Supplementary Table S3 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Differentially expressed genes of intratumoural CD103+CD56+ ILCs compared to CD103-CD56+ NK cells from HGSC tumours using bulk-RNAseq.

Supplementary Table 7 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Transcription factor regulons that were enriched in CD103+CD56+ ILCs from scRNA-seq.

Supplementary Figure S6 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Fig. S6. CD103+CD56+ ILCs have distinct transcriptional networks revealed by SCENIC analysis.

Supplementary Figure S4 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Fig S4. CD101 and GITR expression is expressed on CD103+CD49a+CD56+Lin- ILCs but not other NK cell subsets.

Supplementary Table S4 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

List of gene sets enriched in CD103+CD56+ ILCs from GSEA using bulk-RNAseq.

Supplementary Figure S2 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Fig. S2. CD103+CD56+Lin- ILCs express distinct gene expression compared to CD103-CD56+Lin-ILCs.

Supplementary Table S5 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Proportion of cells per clusters for each patient sample from scRNA-seq and CITE-seq datasets.

Supplementary Figure S1 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Fig. S1. Gating strategy for intratumoural ILCs.

Supplementary Figure S3 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Fig. S3. CD103+CD56+Lin- ILCs exhibit features that are associated with Tregs.

CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment Open

Douglas C. Chung, Noor Shakfa, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot , et al. · 2025

Immunotherapies have had unprecedented success in the treatment of multiple cancer types, albeit with variable response rates. Unraveling the complex network of immune cells within the tumor microenvironment (TME) may provide additional in…

365 Artificial intelligence-based dynamic single-cell imaging reveals enhanced migration and immune synapse formation by IDP-023, an allogeneic g-NK cell product Open

Matthew R. Collinson-Pautz, Hannah Wilson, Mohsen Fathi, Lyle W. Babcock, Linh T. Nguyen , et al. · 2024

Generation of an Inhibitory NK Cell Subset by TGF-β1/IL-15 Polarization Open

Douglas C. Chung, Carlos R. Garcia-Batres, Douglas G. Millar, Stephanie WY Wong, Alisha R. Elford , et al. · 2024

NK cells have been shown to exhibit inflammatory and immunoregulatory functions in a variety of healthy and diseased settings. In the context of chronic viral infection and cancer, distinct NK cell populations that inhibit adaptive immune …

The budding yeast heterochromatic protein Sir3 modulates genome-wide gene expression through transient direct contacts with euchromatin Open

Marta Radman‐Livaja, Pritha Bhattacharjee, Alain Camasses, Hrvoje Galić, Ana Hrgovčić , et al. · 2023

The SIR complex (Silent Information Regulator) is the building block of heterochromatic structures that silence underlying genes. The biological function of heterochromatin located in subtelomeric regions is, however still not clear since …

Chimeric TIM-4 receptor-modified T cells targeting phosphatidylserine mediates both cytotoxic anti-tumor responses and phagocytic uptake of tumor-associated antigen for T cell cross-presentation Open

Brandon Cieniewicz, Ankit Bhatta, Damoun Torabi, Priya Baichoo, Mike Saxton , et al. · 2023

To leverage complementary mechanisms for cancer cell removal, we developed a novel cell engineering and therapeutic strategy co-opting phagocytic clearance and antigen presentation activity into T cells. We engineered a chimeric engulfment…

A novel population of CD103-expressing CD56+ regulatory ILCs suppresses intratumoural T cells and are associated with poor prognosis in patients with ovarian carcinoma Open

Douglas C. Chung, Jehan Vakharia, Kathrin Warner, Nicolas Jacquelot, Azin Sayad , et al. · 2023

Regulatory innate lymphoid cells (ILCregs) are an emerging family of immunoregulatory cells that suppress innate and adaptive immunity in the context of diseases, including cancer. However, there is currently a lack of lineage-defining sur…

Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire Open

Douglas G. Millar, S.Y. Cindy Yang, Azin Sayad, Qingchuan Zhao, Linh T. Nguyen , et al. · 2023

Immunotherapeutic strategies aimed at enhancing tumor cell killing by tumor-specific T cells hold great potential for reducing tumor burden and prolonging survival of cancer patients. Although many potential tumor antigens have been descri…

Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer Open

Bernhard Mlecnik, Alessandro Lugli, Gabriela Bindea, Florence Marliot, Carlo Bifulco , et al. · 2023

Background: The prognostic value of Immunoscore was evaluated in Stage II/III colon cancer (CC) patients, but it remains unclear in Stage I/II, and in early-stage subgroups at risk. An international Society for Immunotherapy of Cancer (SIT…

Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study Open

Bernhard Mlecnik, Toshihiko Torigoe, Gabriela Bindea, Boryana Konstantinova Popivanova, Mingli Xu , et al. · 2022

BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I–III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Im…

Expansion of Lymphocytes from Prostatic Adenocarcinoma and Adjacent Nonmalignant Tissue Open

Linh T. Nguyen, Charlotte S. Lo, Michael Fyrsta, Jessica Nie, Jennifer Yam , et al. · 2022

Background. The evaluation of tumour-infiltrating lymphocytes (TILs) in solid malignancies has yielded insights into immune regulation within the tumour microenvironment and has also led to the development and optimisation of adoptive T ce…

Citizen scientists track a charismatic carnivore: Mapping the spread and impact of the South African Mantis (Miomantidae, Miomantis caffra) in Australia Open

MATTHEW G. CONNORS, Honglei Chen, Haokun Li, Adam Edmonds, Kimberley A. Smith , et al. · 2022

The recent integration of citizen science with modern technology has greatly increased its applications and has allowed more people than ever to contribute to research across all areas of science. In particular, citizen science has been in…

Linh T. Nguyen YOU? Author Swipe