Tyler A. Harm
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View article: Infection of prepubertal heifer calves as a natural host model for Tritrichomonas foetus
Infection of prepubertal heifer calves as a natural host model for Tritrichomonas foetus Open
Introduction Tritrichomonas foetus is a sexually transmitted flagellate that causes economic loss in the cattle industry throughout the world. In the United States, there are no approved treatments for the parasite. Owing to its transmissi…
View article: Perineal Urethrostomy Enables Susceptibility of Bull Calves as a Natural Host Model for Bovine Trichomonosis
Perineal Urethrostomy Enables Susceptibility of Bull Calves as a Natural Host Model for Bovine Trichomonosis Open
Tritrichomonas foetus is a sexually transmitted protozoan that causes early embryonic death in cattle. A challenge in trichomonosis research is that in vivo studies of treatments, diagnostic strategies, and vaccines are severely hampered b…
View article: Exploring influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock and in human breast tissue
Exploring influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock and in human breast tissue Open
The spread of the highly pathogenic avian influenza (HPAI) H5N1 virus among dairy cattle illustrates the adaptability of influenza A viruses (IAV) to infect non-traditional species. While IAV-specific sialic acid (SA) receptors have been i…
View article: Sialic Acid Receptor Specificity in Mammary Gland of Dairy Cattle Infected with Highly Pathogenic Avian Influenza A(H5N1) Virus
Sialic Acid Receptor Specificity in Mammary Gland of Dairy Cattle Infected with Highly Pathogenic Avian Influenza A(H5N1) Virus Open
In March 2024, the US Department of Agriculture's Animal and Plant Health Inspection Service reported detection of highly pathogenic avian influenza (HPAI) A(H5N1) virus in dairy cattle in the United States for the first time. One factor t…
View article: Enteropathy and bone marrow hypoplasia associated with presumptive albendazole toxicosis in a juvenile Boer goat
Enteropathy and bone marrow hypoplasia associated with presumptive albendazole toxicosis in a juvenile Boer goat Open
Albendazole is a widely used anthelmintic drug that is labeled for the treatment of specific nematodes and flukes in ruminants. Albendazole is approved for the treatment of liver flukes in goats (10 mg/kg PO for a single dose), but is comm…
View article: Neuropathologic characterization of a canine model of mucopolysaccharidosis IIIB and additional studies in anti-inflammatory therapy and neuroinflammatory kinetics
Neuropathologic characterization of a canine model of mucopolysaccharidosis IIIB and additional studies in anti-inflammatory therapy and neuroinflammatory kinetics Open
The mucopolysaccharidoses (MPSs) are a heterogenous group of lysosomal storage diseases that are designated MPS I through MPS IX (excluding MPS V and MPS VIII) that result in deficiencies in specific lysosomal enzymes that are responsible …
View article: Temporospatial Development of Neuropathologic Findings in a Canine Model of Mucopolysaccharidosis IIIB
Temporospatial Development of Neuropathologic Findings in a Canine Model of Mucopolysaccharidosis IIIB Open
Mucopolysaccharidosis (MPS) IIIB is a neuropathic lysosomal storage disease characterized by the deficient activity of a lysosomal enzyme obligate for the degradation of the glycosaminoglycan (GAG) heparan sulfate (HS). The pathogenesis of…
View article: In Situ Temporospatial Characterization of the Glial Response to Prion Infection
In Situ Temporospatial Characterization of the Glial Response to Prion Infection Open
Mammalian transmissible spongiform encephalopathies (TSEs) display marked activation of astrocytes and microglia that precedes neuronal loss. Investigation of clinical parallels between TSEs and other neurodegenerative protein misfolding d…