Tianyang Han
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View article: Formulation Redesigning of Itaconate Treats Periodontitis via Nrf2/TFAM‐Mediated Reprogramming of Mitochondrial Metabolism
Formulation Redesigning of Itaconate Treats Periodontitis via Nrf2/TFAM‐Mediated Reprogramming of Mitochondrial Metabolism Open
Periodontitis is the leading cause of tooth loss in adults. Unfortunately, inflammation remains poorly controlled and prone to relapse, even after removing the initial plaque biofilm. The unique metabolic properties of mitochondria in the …
View article: Personalized Visual Instruction Tuning
Personalized Visual Instruction Tuning Open
Recent advancements in multimodal large language models (MLLMs) have demonstrated significant progress; however, these models exhibit a notable limitation, which we refer to as "face blindness". Specifically, they can engage in general con…
View article: Tumor Receptor-Seeking Dyes for Rapid Intraoperative Definition of Tumor Margin and Histopathological Morphology
Tumor Receptor-Seeking Dyes for Rapid Intraoperative Definition of Tumor Margin and Histopathological Morphology Open
Open AccessCCS ChemistryRESEARCH ARTICLES8 Mar 2024Tumor Receptor-Seeking Dyes for Rapid Intraoperative Definition of Tumor Margin and Histopathological Morphology Yajun Wang, Feiran Zhang, Yunlong Jia, Tianyang Han, Chengbin Zhang, Limei …
View article: The Instinctive Bias: Spurious Images lead to Illusion in MLLMs
The Instinctive Bias: Spurious Images lead to Illusion in MLLMs Open
Large language models (LLMs) have recently experienced remarkable progress, where the advent of multi-modal large language models (MLLMs) has endowed LLMs with visual capabilities, leading to impressive performances in various multi-modal …
View article: Site-specific albumin tagging with NIR-II fluorogenic dye for high-performance and super-stable bioimaging
Site-specific albumin tagging with NIR-II fluorogenic dye for high-performance and super-stable bioimaging Open
Synthetic near-infrared-II (NIR-II) dyes are promising for deep tissue imaging, yet they are generally difficult to target a given biomolecule with high specificity. Furthermore, the interaction mechanism between albumin and cyanine molecu…
View article: Albumin-seeking dyes with adjustable assemblies <i>in situ</i> enable programmable imaging windows and targeting tumor imaging
Albumin-seeking dyes with adjustable assemblies <i>in situ</i> enable programmable imaging windows and targeting tumor imaging Open
Cyanine dyes are widely used organic probes for in vivo imaging due to their tunable fluorescence. They can form complexes with endogenous albumin, resulting in enhanced brightness and photostability. However, this binding is uncontrollabl…
View article: The Instinctive Bias: Spurious Images lead to Illusion in MLLMs
The Instinctive Bias: Spurious Images lead to Illusion in MLLMs Open
Large language models (LLMs) have recently experienced remarkable progress, where the advent of multi-modal large language models (MLLMs) has endowed LLMs with visual capabilities, leading to impressive performances in various multi-modal …
View article: Near‐Infrared Carbonized Polymer Dots for NIR‐II Bioimaging
Near‐Infrared Carbonized Polymer Dots for NIR‐II Bioimaging Open
Carbon dots (CDs) or carbonized polymer dots (CPDs) are an emerging class of optical materials that have exceptional applications in optoelectronic devices, catalysis, detection, and bioimaging. Although cell studies of CPDs have produced …
View article: Surfactant-chaperoned donor–acceptor–donor NIR-II dye strategy efficiently circumvents intermolecular aggregation to afford enhanced bioimaging contrast
Surfactant-chaperoned donor–acceptor–donor NIR-II dye strategy efficiently circumvents intermolecular aggregation to afford enhanced bioimaging contrast Open
PEGylation of donor–acceptor–donor (D–A–D) dyes causes inherent self-assembly thus unavoidably reducing their intrinsic brightness. We develop a new surfactant-chaperoned strategy to conquer the intermolecular aggregation of NIR-II fluorop…
View article: Super-stable cyanine@albumin fluorophore for enhanced NIR-II bioimaging
Super-stable cyanine@albumin fluorophore for enhanced NIR-II bioimaging Open
Near-infrared-II (NIR-II) dyes could be encapsulated by either exogenous or endogenous albumin to form stable complexes for deep tissue bioimaging. However, we still lack a complete understanding of the interaction mechanism of the dye@alb…
View article: Near-infrared-II ratiometric fluorescence probes for non-invasive detection and precise navigation surgery of metastatic sentinel lymph nodes
Near-infrared-II ratiometric fluorescence probes for non-invasive detection and precise navigation surgery of metastatic sentinel lymph nodes Open
Sentinel lymph node (SLN) biopsy is the key diagnostic procedure to determine tumor metastasis and treatment plan. Current SLN biopsy has considerable drawbacks in that SLNs (both malignant and normal) must be removed by navigation surgery…
View article: Indole Carbonized Polymer Dots Boost Full-Color Emission by Regulating Surface State
Indole Carbonized Polymer Dots Boost Full-Color Emission by Regulating Surface State Open
Carbonized polymer dots (CPDs) are impressive imaging probes with great potential for enriching the library of metal-free fluorescent materials, yet current strategies have struggled to achieve products that emit full-color light in a sing…
View article: Ultrasonic additive manufacturing of 4130 steel using Ni interlayers
Ultrasonic additive manufacturing of 4130 steel using Ni interlayers Open
Ultrasonic additive manufacturing (UAM) is a solid-state manufacturing process for making complex components. However, fabrication of ferritic (body centered cubic) steels has been challenging for UAM due to its high hardness. This researc…
View article: Direct observation of ultrafast plasmonic hot electron transfer in the strong coupling regime
Direct observation of ultrafast plasmonic hot electron transfer in the strong coupling regime Open
Achieving strong coupling between plasmonic oscillators can significantly modulate their intrinsic optical properties. Here, we report the direct observation of ultrafast plasmonic hot electron transfer from an Au grating array to an MoS 2…
View article: Research on Short-Term Load Forecasting Based on Improved Support Vector Regression
Research on Short-Term Load Forecasting Based on Improved Support Vector Regression Open
Firstly, according to the disadvantages of the artificial bee colony algorithm which is easy to fall into the local optimum and the convergence rate is slow, this paper introduce the current optimal food source and inertia weight function …