Tyler J. Ward
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View article: Cortical thickness changes precede high levels of amyloid by at least seven years
Cortical thickness changes precede high levels of amyloid by at least seven years Open
Alzheimer’s disease (AD) is now defined based on its underlying brain pathology 1 , with the presence of amyloid (Aβ) plaques at high enough levels sufficient to warrant a diagnosis in the absence of cognitive symptoms. High levels of PET-…
View article: Lipid mediated formation of antiparallel aggregates in cerebral amyloid angiopathy
Lipid mediated formation of antiparallel aggregates in cerebral amyloid angiopathy Open
View article: Modifiable risk factor profiles moderate the effect of β-amyloid pathology on cognition in aging
Modifiable risk factor profiles moderate the effect of β-amyloid pathology on cognition in aging Open
Although modifiable risk factors may account for around 40 % of population variability in dementia risk, the effect of risk factor interrelationships on pathology-cognition relationships is poorly understood. Using risk factor data from a …
View article: Lipid Mediated Formation of Antiparallel Aggregates in Cerebral Amyloid Angiopathy
Lipid Mediated Formation of Antiparallel Aggregates in Cerebral Amyloid Angiopathy Open
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder marked by amyloid-β (Aβ) deposition in blood vessel walls, leading to hemorrhage and recurring stroke. Despite significant overlap with Alzheimer’s disease (AD) through shared…
View article: Cognitive aging outcomes are related to both tau pathology and maintenance of cingulate cortex structure
Cognitive aging outcomes are related to both tau pathology and maintenance of cingulate cortex structure Open
INTRODUCTION Successful cognitive aging is related to both maintaining brain structure and avoiding Alzheimer's disease (AD) pathology, but how these factors interplay is unclear. METHODS A total of 109 cognitively normal older adults (70+…
View article: Elevated AD Biomarkers Do Not Explain Cognitive Performance in a Community-Recruited Clinical Trial Cohort
Elevated AD Biomarkers Do Not Explain Cognitive Performance in a Community-Recruited Clinical Trial Cohort Open
View article: The POINTER Imaging baseline cohort: Associations between multimodal neuroimaging biomarkers, cardiovascular health, and cognition
The POINTER Imaging baseline cohort: Associations between multimodal neuroimaging biomarkers, cardiovascular health, and cognition Open
INTRODUCTION The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is evaluating lifestyle interventions in older adults at risk for cognitive decline and dementia. Here we characterize the bas…
View article: Associations between imaging biomarkers and sleep quality in the U.S. POINTER study baseline cohort
Associations between imaging biomarkers and sleep quality in the U.S. POINTER study baseline cohort Open
Background Worse sleep is associated with a greater risk of Alzheimer’s disease (AD). However, few studies have linked objective sleep with neuroimaging outcomes, limiting our understanding of how poor sleep impacts the brain. The U.S. POI…
View article: Associations between imaging biomarkers and sleep quality in the U.S. POINTER study baseline cohort
Associations between imaging biomarkers and sleep quality in the U.S. POINTER study baseline cohort Open
Background Worse sleep is associated with a greater risk of Alzheimer’s disease (AD). However, few studies have linked objective sleep with neuroimaging outcomes, limiting our understanding of how poor sleep impacts the brain. The U.S. POI…
View article: Generalizability of demographic and genetic variable interactions with amyloid driving tau burden in a heterogeneous group of cognitively normal older adults: A multi‐cohort study
Generalizability of demographic and genetic variable interactions with amyloid driving tau burden in a heterogeneous group of cognitively normal older adults: A multi‐cohort study Open
Background Efforts to increase heterogeneity in cohorts of cognitively normal older adults with Alzheimer’s disease (AD) neuroimaging biomarkers have resulted in large datasets with differing characteristics. It is unclear whether associat…
View article: Quantification of tau pathology in the basal forebrain: Associations with age, amyloid, brain structure and cognition
Quantification of tau pathology in the basal forebrain: Associations with age, amyloid, brain structure and cognition Open
Background Tau pathology accumulates early in the basal forebrain (BF) in Alzheimer’s disease (AD). The feasibility of measuring in vivo BF tau is unclear given PET resolution and possible partial volume effects of off‐target signal (OTS) …
View article: Clusters of modifiable risk factors provide resilience to the cognitive effects of β‐amyloid pathology in aging
Clusters of modifiable risk factors provide resilience to the cognitive effects of β‐amyloid pathology in aging Open
Background Although it has been estimated that modifiable risk factors account for around 40% of population variability in dementia risk, understanding how risk factors are related to one another and to brain pathology and cognition has be…
View article: Quantification of tau pathology in the basal forebrain: Associations with age, amyloid, brain structure and cognition
Quantification of tau pathology in the basal forebrain: Associations with age, amyloid, brain structure and cognition Open
Background Tau pathology accumulates early in the basal forebrain (BF) in Alzheimer’s disease (AD). The feasibility of measuring in vivo BF tau is unclear given PET resolution and possible partial volume effects of off‐target signal (OTS) …
View article: Clusters of modifiable risk factors provide resilience to the cognitive effects of β‐amyloid pathology in aging
Clusters of modifiable risk factors provide resilience to the cognitive effects of β‐amyloid pathology in aging Open
Background Although it has been estimated that modifiable risk factors account for around 40% of population variability in dementia risk, understanding how risk factors are related to one another and to brain pathology and cognition has be…
View article: Positron emission tomography harmonization in the Alzheimer's Disease Neuroimaging Initiative: A scalable and rigorous approach to multisite amyloid and tau quantification
Positron emission tomography harmonization in the Alzheimer's Disease Neuroimaging Initiative: A scalable and rigorous approach to multisite amyloid and tau quantification Open
INTRODUCTION A key goal of the Alzheimer's Disease NeuroImaging Initiative (ADNI) positron emission tomography (PET) Core is to harmonize quantification of β‐amyloid (Aβ) and tau PET image data across multiple scanners and tracers. METHODS…
View article: Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology Open
INTRODUCTION Factors responsible for the deposition of pathological tau in the brain are incompletely understood. This study links macroscale tau deposition in the human brain to cerebrospinal fluid (CSF) flow dynamics using resting‐state …
View article: Areas of Improvement for Autonomous Vehicles: A Machine Learning Analysis of Disengagement Reports
Areas of Improvement for Autonomous Vehicles: A Machine Learning Analysis of Disengagement Reports Open
Since 2014, the California Department of Motor Vehicles (CDMV) has compiled information from manufacturers of autonomous vehicles (AVs) regarding factors that lead to the disengagement from autonomous driving mode in these vehicles. These …
View article: Individuals with Alzheimer's disease and low tau burden: Characteristics and implications
Individuals with Alzheimer's disease and low tau burden: Characteristics and implications Open
INTRODUCTION Abnormal amyloid‐beta (Aβ) and tau deposition define Alzheimer's Disease (AD), but non‐elevated tau is relatively frequent in patients on the AD pathway. METHODS We examined characteristics and regional patterns of 397 Aβ+ uni…
View article: MRI-free processing of tau PET images for early detection
MRI-free processing of tau PET images for early detection Open
Tau positron emission tomography (PET) imaging in Alzheimer’s Disease (AD) is becoming increasingly common to assess in vivo tau burden. MR images are often acquired to assist with processing of PET data, including for region-of-interest d…
View article: Cohort heterogeneity and AD biomarkers in older adults without significant cognitive impairment: A comparison of U.S. POINTER and ADNI
Cohort heterogeneity and AD biomarkers in older adults without significant cognitive impairment: A comparison of U.S. POINTER and ADNI Open
Background A key focus of the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is recruitment of unimpaired older individuals at risk for cognitive decline with heterogeneous characteristics (…
View article: The impact of Alzheimer’s disease pathology and cardiovascular risk factors on cross‐sectional brain structure in the U.S. POINTER Imaging study
The impact of Alzheimer’s disease pathology and cardiovascular risk factors on cross‐sectional brain structure in the U.S. POINTER Imaging study Open
Background The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is a 2‐year randomized controlled trial to evaluate the effect of lifestyle interventions in cognitively unimpaired older adults…
View article: Cohort heterogeneity and AD biomarkers in older adults without significant cognitive impairment: A comparison of U.S. POINTER and ADNI
Cohort heterogeneity and AD biomarkers in older adults without significant cognitive impairment: A comparison of U.S. POINTER and ADNI Open
Background A key focus of the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is recruitment of unimpaired older individuals at risk for cognitive decline with heterogeneous characteristics (…
View article: Harmonization of amyloid and tau PET tracers in a multi‐center cohort from NIA Alzheimer’s disease research centers in the United States
Harmonization of amyloid and tau PET tracers in a multi‐center cohort from NIA Alzheimer’s disease research centers in the United States Open
Background The Standardized Centralized Alzheimer’s & related dementias Neuroimaging (SCAN) project harmonizes processing of prospectively acquired PET and MRI scans from Alzheimer’s disease research centers (ADRCs) across the USA. SCAN da…
View article: Harmonization of amyloid and tau PET tracers in a multi‐center cohort from NIA Alzheimer’s disease research centers in the United States
Harmonization of amyloid and tau PET tracers in a multi‐center cohort from NIA Alzheimer’s disease research centers in the United States Open
Background The Standardized Centralized Alzheimer’s & related dementias Neuroimaging (SCAN) project harmonizes processing of prospectively acquired PET and MRI scans from Alzheimer’s disease research centers (ADRCs) across the USA. SCAN da…
View article: Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology Open
A bstract Amyloid-β (Aβ) and tau deposition constitute Alzheimer’s disease (AD) neuropathology. Cortical tau deposits first in the entorhinal cortex and hippocampus and then propagates to neocortex in an Aβ-dependent manner. Tau also tends…
View article: Tau heterogeneity in Aβ positive patients
Tau heterogeneity in Aβ positive patients Open
Background A substantial proportion of individuals on the AD continuum have tau PET burden that is not elevated, suggesting that they may be in an earlier stage on the AD continuum and/or have other copathologies that account for their imp…
View article: Whole brain MRI‐free tau and amyloid PET quantification
Whole brain MRI‐free tau and amyloid PET quantification Open
Background The growing use of PET imaging in Alzheimer’s research and clinical practice has resulted in the need for PET quantification when an MRI is unavailable or contraindicated. The Desikan‐Killiany (DK) atlas in Freesurfer (FS) is of…
View article: Tau PET shows both direct and atrophy‐mediated effects on cognition: 4‐way decomposition of the effects of tau PET and atrophy on cognitive performance
Tau PET shows both direct and atrophy‐mediated effects on cognition: 4‐way decomposition of the effects of tau PET and atrophy on cognitive performance Open
Background Evidence suggests that tau pathology predicts subsequent neurodegeneration and that atrophy is associated with cognitive impairment. However, in vivo studies have shown that structural measures only partially mediate tau‐cogniti…
View article: Optimizing quantification of MK6240 tau PET in unimpaired older adults
Optimizing quantification of MK6240 tau PET in unimpaired older adults Open
View article: Quantification of amyloid beta and tau PET without a structural MRI
Quantification of amyloid beta and tau PET without a structural MRI Open
Introduction Relying on magnetic resonance imaging (MRI) for quantification of positron emission tomography (PET) images may limit generalizability of the results. We evaluated several MRI‐free approaches for amyloid beta (Aβ) and tau PET …