Tyler S. Nelson
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View article: A parabrachial hub for need-state control of enduring pain
A parabrachial hub for need-state control of enduring pain Open
View article: Case Report: Adverse reaction to butorphanol in a Collie homozygous for the ABCB1-1∆ (MDR1) mutation
Case Report: Adverse reaction to butorphanol in a Collie homozygous for the ABCB1-1∆ (MDR1) mutation Open
Certain dog breeds, particularly herding breeds like Collies, are predisposed to drug sensitivity due to the ABCB1-1∆ (previously known as MDR1 ) mutation, which disrupts P-glycoprotein (P-gp) function. This mutation impairs drug efflux at…
View article: Amygdalar Calcitonin Gene-Related Peptide Driven Effects of Cold Sensitivity Induced by Peripheral Neuropathy in Mice
Amygdalar Calcitonin Gene-Related Peptide Driven Effects of Cold Sensitivity Induced by Peripheral Neuropathy in Mice Open
The central nucleus of the amygdala (CeA) is a critical regulator of nociception, and its role in pain modulation depends on factors such as hemispheric location, neuropeptide release, and experimental model. Calcitonin gene-related peptid…
View article: Parabrachial bombesin receptor subtype 3 neurons facilitate heat pain in persistent inflammation
Parabrachial bombesin receptor subtype 3 neurons facilitate heat pain in persistent inflammation Open
The parabrachial nucleus (PBN) is a critical hub for pain processing that acts as a switchboard for nociceptive signals, relaying them to forebrain regions that integrate sensory signals with affective aspects of pain. Despite strong evide…
View article: C2230, a preferential use- and state-dependent CaV2.2 channel blocker, mitigates pain behaviors across multiple pain models
C2230, a preferential use- and state-dependent CaV2.2 channel blocker, mitigates pain behaviors across multiple pain models Open
Antagonists - such as Ziconotide and Gabapentin - of the CaV2.2 (N-type) calcium channels are used clinically as analgesics for chronic pain. However, their use is limited by narrow therapeutic windows, difficult dosing routes (Ziconotide)…
View article: A synthetic potassium channel reduces oxidative stress via cellular adaptronics
A synthetic potassium channel reduces oxidative stress via cellular adaptronics Open
Summary Aerobic metabolism is crucial for human life but reactive oxygen species (ROS) byproducts cause cellular toxicity. Although antioxidant defenses usually maintain ROS levels within a safe range, ROS production can exceed the bufferi…
View article: Neuropeptide Y and Pain: Insights from Brain Research
Neuropeptide Y and Pain: Insights from Brain Research Open
Neuropeptide Y (NPY) is a highly conserved neuropeptide with widespread distribution in the central nervous system and diverse physiological functions. While extensively studied for its inhibitory effects on pain at the spinal cord level, …
View article: Uncoupling the CRMP2-CaV2.2 Interaction Reduces Pain-Like Behavior in a Preclinical Joint-Pain Model
Uncoupling the CRMP2-CaV2.2 Interaction Reduces Pain-Like Behavior in a Preclinical Joint-Pain Model Open
View article: Mouse models of non-dystrophic and dystrophic myotonia exhibit nociplastic pain-like behaviors
Mouse models of non-dystrophic and dystrophic myotonia exhibit nociplastic pain-like behaviors Open
Pain is a prominent and debilitating symptom in myotonic disorders, including myotonia congenita and myotonic dystrophy type 1 (DM1). Although patients frequently report chronic pain, its underlying mechanisms remain poorly defined. In bot…
View article: Uncoupling the CRMP2-Ca<sub>V</sub>2.2 interaction reduces pain-like behavior in a preclinical osteoarthritis model
Uncoupling the CRMP2-Ca<sub>V</sub>2.2 interaction reduces pain-like behavior in a preclinical osteoarthritis model Open
Osteoarthritis (OA) represents a significant pain challenge globally, as current treatments are limited and come with substantial and adverse side effects. Voltage-gated calcium channels have proved to be pharmacologically effective target…
View article: Parabrachial Calca neurons drive nociplasticity
Parabrachial Calca neurons drive nociplasticity Open
View article: A parabrachial hub for the prioritization of survival behavior
A parabrachial hub for the prioritization of survival behavior Open
Long-term sustained pain in the absence of acute physical injury is a prominent feature of chronic pain conditions. While neurons responding to noxious stimuli have been identified, understanding the signals that persist without ongoing pa…
View article: A peptidomimetic modulator of the Ca <sub>V</sub> 2.2 N-type calcium channel for chronic pain
A peptidomimetic modulator of the Ca <sub>V</sub> 2.2 N-type calcium channel for chronic pain Open
Transmembrane Ca v 2.2 (N-type) voltage-gated calcium channels are genetically and pharmacologically validated, clinically relevant pain targets. Clinical block of Ca v 2.2 (e.g., with Prialt/Ziconotide) or indirect modulation [e.g., with …
View article: Parabrachial<i>Calca</i>neurons drive nociplasticity
Parabrachial<i>Calca</i>neurons drive nociplasticity Open
Pain that persists beyond the time required for tissue healing and pain that arises in the absence of tissue injury are poorly understood phenomena mediated by plasticity within the central nervous system. The parabrachial nucleus (PBN) is…
View article: Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain
Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain Open
The voltage-gated sodium channel Na V 1.7 is an essential component of human pain signaling. Changes in Na V 1.7 trafficking are considered critical in the development of neuropathic pain. SUMOylation of collapsin response mediator protein…
View article: Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that coexpress Grp
Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that coexpress Grp Open
Neuropeptide Y targets the Y1 receptor (Y1) in the spinal dorsal horn (DH) to produce endogenous and exogenous analgesia. DH interneurons that express Y1 (Y1-INs; encoded by Npy1r) are necessary and sufficient for neuropathic hypersensitiv…
View article: The spino-parabrachio-amygdaloid pathway is critical for the manifestation of chronic pain
The spino-parabrachio-amygdaloid pathway is critical for the manifestation of chronic pain Open
View article: Contribution of µ Opioid Receptor–expressing Dorsal Horn Interneurons to Neuropathic Pain–like Behavior in Mice
Contribution of µ Opioid Receptor–expressing Dorsal Horn Interneurons to Neuropathic Pain–like Behavior in Mice Open
Background Intersectional genetics have yielded tremendous advances in our understanding of molecularly identified subpopulations and circuits within the dorsal horn in neuropathic pain. The authors tested the hypothesis that spinal µ opio…
View article: Endogenous μ-opioid—Neuropeptide Y Y1 receptor synergy silences chronic postoperative pain in mice
Endogenous μ-opioid—Neuropeptide Y Y1 receptor synergy silences chronic postoperative pain in mice Open
Tissue injury creates a delicate balance between latent pain sensitization (LS) and compensatory endogenous analgesia. Inhibitory G-protein-coupled receptor (GPCR) interactions that oppose LS, including μ-opioid receptor (MOR) or neuropept…
View article: Neuropilin-1 is essential for vascular endothelial growth factor A–mediated increase of sensory neuron activity and development of pain-like behaviors
Neuropilin-1 is essential for vascular endothelial growth factor A–mediated increase of sensory neuron activity and development of pain-like behaviors Open
Neuropilin-1 (NRP-1) is a transmembrane glycoprotein that binds numerous ligands including vascular endothelial growth factor A (VEGFA). Binding of this ligand to NRP-1 and the co-receptor, the tyrosine kinase receptor VEGFR2, elicits noci…
View article: Neuropeptide Y1 Interneurons In Inflammatory Pain Circuits
Neuropeptide Y1 Interneurons In Inflammatory Pain Circuits Open
View article: The Emerging Translational Potential of MNK Inhibitors for the Treatment of Chronic Pain
The Emerging Translational Potential of MNK Inhibitors for the Treatment of Chronic Pain Open
View article: Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain
Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain Open
Peripheral nerve injury sensitizes a complex network of spinal cord dorsal horn (DH) neurons to produce allodynia and neuropathic pain. The identification of a druggable target within this network has remained elusive, but a promising cand…
View article: Endogenous μ-opioid – neuropeptide Y Y1 receptor synergy silences chronic postoperative pain
Endogenous μ-opioid – neuropeptide Y Y1 receptor synergy silences chronic postoperative pain Open
Tissue injury creates a delicate balance between latent pain sensitization (LS) and compensatory endogenous analgesia. Inhibitory G protein-coupled receptor (GPCR) interactions that oppose LS, including μ-opioid receptor (MOR) and neuropep…
View article: Behavioral and neurophysiological taste responses to sweet and salt are diminished in a model of subclinical intestinal inflammation
Behavioral and neurophysiological taste responses to sweet and salt are diminished in a model of subclinical intestinal inflammation Open
There is strong evidence for gut-taste bud interactions that influence taste function, behavior and feeding. However, the effect of gut inflammation on this axis is unknown despite reports of taste changes in gastrointestinal (GI) inflamma…
View article: Targeting spinal neuropeptide Y1 receptor-expressing interneurons to alleviate chronic pain and itch
Targeting spinal neuropeptide Y1 receptor-expressing interneurons to alleviate chronic pain and itch Open
View article: Lymphatic remodelling in response to lymphatic injury in the hind limbs of sheep
Lymphatic remodelling in response to lymphatic injury in the hind limbs of sheep Open
View article: Dorsal Horn PKCγ Interneurons Mediate Mechanical Allodynia through 5-HT<sub>2A</sub>R-Dependent Structural Reorganization
Dorsal Horn PKCγ Interneurons Mediate Mechanical Allodynia through 5-HT<sub>2A</sub>R-Dependent Structural Reorganization Open
Nociceptors function to protect tissue from potential damage by thermal, mechanical, and chemical stimuli. The central terminals of primary nociceptive mechanical and thermal afferents (C/Aδ fibers) converge in superficial laminae I and II…
View article: A novel mouse tail lymphedema model for observing lymphatic pump failure during lymphedema development
A novel mouse tail lymphedema model for observing lymphatic pump failure during lymphedema development Open
It has been suggested that many forms of secondary lymphedema in humans are driven by a progressive loss of lymphatic pump function after an initial risk-inducing event. However, the link between pump failure and disease progression has re…
View article: Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn
Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn Open