Tyrah M. Ritchie
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View article: Microglia promote bystander activated T cell-mediated neurological disease during viral infection 3059
Microglia promote bystander activated T cell-mediated neurological disease during viral infection 3059 Open
Description Many viral infections have been linked to the development of debilitating neurological disorders. However, the mechanism governing virus-induced neuropathology remains poorly understood, particularly when the virus is not direc…
View article: Oral cannabis disrupts uterine NK cell function leading to impaired decidual vessel remodeling and fetal growth in mice 3373
Oral cannabis disrupts uterine NK cell function leading to impaired decidual vessel remodeling and fetal growth in mice 3373 Open
Description The consumption of cannabis during pregnancy has increased in recent years following the widespread legalization of recreational cannabis. However, accumulating evidence uncovers the detrimental harm of cannabis and specificall…
View article: IL-21-reprogrammed Vδ1 T cells exert killing against solid tumors which is enhanced by CAR arming for off-the-shelf immunotherapy
IL-21-reprogrammed Vδ1 T cells exert killing against solid tumors which is enhanced by CAR arming for off-the-shelf immunotherapy Open
Cancer cell therapies have primarily focused on engineering autologous αβ T cells with chimeric antigen receptors (CARs), achieving clinical success against hematologic malignancies. However, their effectiveness against solid tumors is lim…
View article: The impact of oral cannabis consumption during pregnancy on maternal spiral artery remodelling, fetal growth and offspring behaviour in mice
The impact of oral cannabis consumption during pregnancy on maternal spiral artery remodelling, fetal growth and offspring behaviour in mice Open
The Michael G. DeGroote Centre for Medicinal Cancer Research, the Canadian Institutes of Health Research, and the Canadian Foundation for Innovation.
View article: Bystander activated CD8+ T cells mediate neuropathology during viral infection via antigen-independent cytotoxicity
Bystander activated CD8+ T cells mediate neuropathology during viral infection via antigen-independent cytotoxicity Open
Although many viral infections are linked to the development of neurological disorders, the mechanism governing virus-induced neuropathology remains poorly understood, particularly when the virus is not directly neuropathic. Using a mouse …
View article: Charting a killer course to the solid tumor: strategies to recruit and activate NK cells in the tumor microenvironment
Charting a killer course to the solid tumor: strategies to recruit and activate NK cells in the tumor microenvironment Open
The ability to expand and activate natural Killer (NK) cells ex vivo has dramatically changed the landscape in the development of novel adoptive cell therapies for treating cancer over the last decade. NK cells have become a key player for…
View article: Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection
Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection Open
The ability to treat severe viral infections is limited by our understanding of the mechanisms behind virus-induced immunopathology. While the role of type I interferons (IFNs) in early control of viral replication is clear, less is known …
View article: Expanded human NK cells from lung cancer patients sensitize patients’ PDL1−negative tumors to PD1-blockade therapy
Expanded human NK cells from lung cancer patients sensitize patients’ PDL1−negative tumors to PD1-blockade therapy Open
Lung cancer remains the leading cause of cancer death worldwide despite the significant progress made by immune checkpoint inhibitors, including programmed death receptor-1 (PD1)/PD ligand 1 (PDL1)-blockade therapy. PD1/PDL1−blockade has a…