Tyrone D. Cannon
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View article: Visual Distortion Screener: A video-based instrument for assessing visual distortions commonly endorsed in psychosis
Visual Distortion Screener: A video-based instrument for assessing visual distortions commonly endorsed in psychosis Open
BackgroundVisual distortions (VDs) represent key markers of psychosis emergence and are highly prevalent amongst patients with psychosis. Existing instruments for VDs depend on verbal descriptions and concurrently assess other perceptual d…
View article: Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics
Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics Open
View article: Excitation/inhibition imbalance and conversion to psychosis in the clinical high risk syndrome: Biophysical modeling finds reduced pyramidal cell excitability across EEG paradigms
Excitation/inhibition imbalance and conversion to psychosis in the clinical high risk syndrome: Biophysical modeling finds reduced pyramidal cell excitability across EEG paradigms Open
Background Reduced mismatch negativity (MMN) and P300 event-related potential (ERP) components are widely replicated in schizophrenia and are also observed in individuals at clinical high risk for psychosis (CHR-P) who subsequently convert…
View article: Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data
Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data Open
Background and Hypothesis Despite significant advances in our understanding of the clinical high risk (CHR) for psychosis state, the longer-term outcomes (5+ years) and the trajectory of diagnoses, symptoms, and psychosocial function have …
View article: Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity
Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity Open
These findings suggest a role of episodic memory processing and inferior parietal lobe activation in the association between DT and psychosis. Focusing further on these measures could provide insight into the underlying mechanism of this a…
View article: Data analysis strategies for the Accelerating Medicines Partnership® Schizophrenia Program
Data analysis strategies for the Accelerating Medicines Partnership® Schizophrenia Program Open
View article: The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program
The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program Open
Neuroimaging with MRI has been a frequent component of studies of individuals at clinical high risk (CHR) for developing psychosis, with goals of understanding potential brain regions and systems impacted in the CHR state and identifying p…
View article: Delineating empirically plausible causal pathways to suicidality among people at clinical high risk for psychosis.
Delineating empirically plausible causal pathways to suicidality among people at clinical high risk for psychosis. Open
Suicidality is common among people at clinical high risk (CHR) for psychosis. Delineating causal pathways to suicidality and identifying its determinants would inform tailored intervention efforts for these individuals. To this end, we ana…
View article: Predicting conversion to psychosis using machine learning: response to Cannon
Predicting conversion to psychosis using machine learning: response to Cannon Open
Background We previously reported that machine learning could be used to predict conversion to psychosis in individuals at clinical high risk (CHR) for psychosis with up to 90% accuracy using the North American Prodrome Longitudinal Study-…
View article: Victimization and Engagement with the Legal System Among Individuals at Clinical High Risk (Chr) for Psychosis
Victimization and Engagement with the Legal System Among Individuals at Clinical High Risk (Chr) for Psychosis Open
View article: Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis
Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis Open
Background Antipsychotic (AP) medication in individuals at clinical high risk for psychosis (CHR-P) is not routinely recommended by clinical guidelines but is commonly prescribed. Since little is known about the predictors of AP inception …
View article: Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis.
Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis. Open
Mismatch negativity (MMN) event-related potential (ERP) component reduction, indexing N-methyl-D-aspartate receptor (NMDAR)-dependent auditory echoic memory and short-term plasticity, is a well-established biomarker of schizophrenia that i…
View article: Convergent Validity of Experimental Cognitive Tests in a Large Community Sample
Convergent Validity of Experimental Cognitive Tests in a Large Community Sample Open
Experimental cognitive tests are designed to measure particular cognitive domains, although evidence supporting test validity is often limited. The Consortium for Neuropsychiatric Phenomics test battery administered 23 experimental and tra…
View article: Attention Deficit Hyperactivity Disorder among Youth at Clinical High Risk of Psychosis
Attention Deficit Hyperactivity Disorder among Youth at Clinical High Risk of Psychosis Open
Attention Deficit Hyperactivity Disorder (ADHD) affects a significant proportion of the population and is associated with numerous adverse outcomes including lower educational attainment, occupational challenges, increased substance use, a…
View article: Impaired belief revision yet intact information seeking in positive schizotypy: A modified task of bias against disconfirmatory evidence
Impaired belief revision yet intact information seeking in positive schizotypy: A modified task of bias against disconfirmatory evidence Open
Cognitive models of delusions emphasize the role of bias against disconfirmatory evidence (BADE) in maintaining false beliefs, but sources of this tendency remain elusive. While impaired information integration could be an explanation for …
View article: Cognitive subtypes in youth at clinical high risk for psychosis
Cognitive subtypes in youth at clinical high risk for psychosis Open
Introduction Schizophrenia is a mental health condition that severely impacts well-being. Cognitive impairment is among its core features, often presenting well before the onset of overt psychosis, underscoring a critical need to study it …
View article: Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition in Schizophrenia and Community-Based Samples
Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition in Schizophrenia and Community-Based Samples Open
Objective Schizophrenia is a neurodevelopmental disorder involving clinical and genetic heterogeneity. Multiple recurrent copy number variants (CNVs) increase risk for schizophrenia spectrum disorders (SSD). However, how known risk CNVs an…
View article: Whole genome sequencing study of identical twins discordant for psychosis
Whole genome sequencing study of identical twins discordant for psychosis Open
Monozygotic (MZ) twins are often thought to have identical genomes, but recent work has shown that early post-zygotic events can result in a spectrum of DNA variants that are different between MZ twins. Such variants may explain phenotypic…
View article: Occasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts
Occasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts Open
View article: Whole genome sequencing study of identical twins discordant for psychosis
Whole genome sequencing study of identical twins discordant for psychosis Open
Monozygotic (MZ) twins are often thought to have identical genomes, but recent work has shown that early post-zygotic events can result in a spectrum of DNA variants that are different between MZ twins. Such variants may explain phenotypic…
View article: Robust Brain Correlates of Cognitive Performance in Psychosis and Its Prodrome
Robust Brain Correlates of Cognitive Performance in Psychosis and Its Prodrome Open
This connectome-wide association study identified reproducible links between connectivity and cognition in separate samples of individuals with psychosis and at-risk individuals who would later develop psychosis. A carefully selected task …
View article: Sex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis
Sex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis Open
Sex differences have been observed in individuals with schizophrenia and for those at clinical high risk (CHR) for psychosis. However, specific differences in CHR individuals who transition to psychosis remain inconsistent and understudied…
View article: Genetically Informed Study Highlights Income-Independent Effect of Schizophrenia Liability on Mental and Physical Health
Genetically Informed Study Highlights Income-Independent Effect of Schizophrenia Liability on Mental and Physical Health Open
Background and Hypothesis Individuals with schizophrenia (SCZ) suffer from comorbidities that substantially reduce their life expectancy. Socioeconomic inequalities could contribute to many of the negative health outcomes associated with S…
View article: The Italian adaptation of the <scp>Mini‐SIPS</scp>, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian <scp>FEP</scp> program
The Italian adaptation of the <span>Mini‐SIPS</span>, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian <span>FEP</span> program Open
Aims The study aims are to present the Italian adaptation of the Abbreviated Clinical Structured Interview for DSM‐5 Attenuated Psychosis Syndrome (Mini‐SIPS) and illustrate its implementation in a clinical setting. Methods The Mini‐SIPS w…
View article: The Complex Latent Structure of Attenuated Psychotic Symptoms: Hierarchical and Bifactor Models of SIPS Symptoms Replicated in Two Large Samples at Clinical High Risk for Psychosis
The Complex Latent Structure of Attenuated Psychotic Symptoms: Hierarchical and Bifactor Models of SIPS Symptoms Replicated in Two Large Samples at Clinical High Risk for Psychosis Open
Background and Hypothesis The Structured Interview for Psychosis-Risk Syndromes (SIPS) and other assessments of psychosis risk define clinical high risk for psychosis (CHR) by the presence of attenuated psychotic symptoms. Despite extensiv…
View article: Information processing style and institutional trust as factors of COVID vaccine hesitancy
Information processing style and institutional trust as factors of COVID vaccine hesitancy Open
View article: Race/ethnicity and socioeconomic status as predictors of outcome following family therapy in youth at clinical high risk for psychosis
Race/ethnicity and socioeconomic status as predictors of outcome following family therapy in youth at clinical high risk for psychosis Open
Aim There is limited research on the effects of sociodemographic and socioeconomic factors on treatment outcomes in youth at clinical high risk for psychosis (CHRp). This study examined sociodemographic factors that may affect functional o…
View article: Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis
Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis Open
Background 22q11.2 Deletion Syndrome (22qDel) is a copy number variant (CNV) associated with psychosis and other neurodevelopmental disorders. Adolescents at clinical high risk for psychosis (CHR) have subthreshold psychosis symptoms witho…
View article: Plasma complement and coagulation proteins as prognostic factors of negative symptoms: An analysis of the NAPLS 2 and 3 studies
Plasma complement and coagulation proteins as prognostic factors of negative symptoms: An analysis of the NAPLS 2 and 3 studies Open
The results indicate that plasma complement and coagulation regulator levels are prognostic factors of negative symptoms, independent of clinical and demographic prognostic factors. These results suggest complement and coagulation regulato…
View article: The hierarchical taxonomy of psychopathology in clinical high risk for psychosis: Validation and extension.
The hierarchical taxonomy of psychopathology in clinical high risk for psychosis: Validation and extension. Open
The Hierarchical Taxonomy of Psychopathology (HiTOP) consortium's transdiagnostic dimensional model of psychopathology has considerable support; however, this model has been underresearched in individuals at clinical high risk for psychosi…