Tyrone L. R. Humphries
YOU?
Author Swipe
View article: Biomarkers in Renal Cell Carcinoma: A Systematic Review and Immunohistochemical Validation Study
Biomarkers in Renal Cell Carcinoma: A Systematic Review and Immunohistochemical Validation Study Open
Background and Objectives: The worldwide incidence of renal cell carcinoma (RCC) rose by 22% between 2012 and 2022. In Australia, RCC accounted for 2.8% of all cancer diagnoses and contributing to 1.8% of cancer-related deaths. Identificat…
View article: Head-to-head comparison of tyrosine kinase inhibitors in renal cell carcinoma using patient-derived cell culture
Head-to-head comparison of tyrosine kinase inhibitors in renal cell carcinoma using patient-derived cell culture Open
Inter-individual variability in the responses of patient-derived RCC cultures to TKIs was seen, which may have biological and clinical significance. Future directions could build on this work to develop personalized cancer susceptibility p…
View article: Metabolite pathway alterations identified by magnetic resonance metabolomics in a proximal tubular epithelial cell line treated with <scp>TGF</scp>‐β1
Metabolite pathway alterations identified by magnetic resonance metabolomics in a proximal tubular epithelial cell line treated with <span>TGF</span>‐β1 Open
Tubulointerstitial fibrosis is a characteristic hallmark of chronic kidney disease (CKD). Metabolic perturbations in cellular energy metabolism contribute to the pathogenesis of CKD, but the chemical contributors remain unclear. The aim of…
View article: Identifying biochemical changes in the kidney using proton nuclear magnetic resonance in an adenine diet chronic kidney disease mouse model
Identifying biochemical changes in the kidney using proton nuclear magnetic resonance in an adenine diet chronic kidney disease mouse model Open
This study aimed to investigate the metabolic changes in the kidneys in a murine adenine–diet model of chronic kidney disease (CKD). Kidney fibrosis is the common pathological manifestation across CKD aetiologies. Sustained inflammation an…
View article: #4344 CHANGES IN ENERGY METABOLISM IN THE KIDNEY WITH TUBULOINTERSTITIAL FIBROSIS: AN EX VIVO WHOLE TISSUE 2D-COSY APPROACH
#4344 CHANGES IN ENERGY METABOLISM IN THE KIDNEY WITH TUBULOINTERSTITIAL FIBROSIS: AN EX VIVO WHOLE TISSUE 2D-COSY APPROACH Open
Background and Aims Tubulointerstitial fibrosis is the common pathological manifestation in chronic kidney disease (CKD) and can indicate whether a patient will progress to kidney failure. The metabolic consequences of developing fibrosis …
View article: Isovalerylglycine and α-Ketobutyrate are novel biomarkers that discriminate clear cell renal cell carcinoma in biopsy specimens using two-dimensional magnetic resonance spectroscopy
Isovalerylglycine and α-Ketobutyrate are novel biomarkers that discriminate clear cell renal cell carcinoma in biopsy specimens using two-dimensional magnetic resonance spectroscopy Open
Tumor heterogeneity and lack of pre-operative diagnostic biomarkers are key topics in the field of renal cell carcinoma (RCC) identification. Clear cell RCC (ccRCC) is an aggressive cancer subtype which accounts for most RCC related deaths…
View article: PAR2-Induced Tissue Factor Synthesis by Primary Cultures of Human Kidney Tubular Epithelial Cells Is Modified by Glucose Availability
PAR2-Induced Tissue Factor Synthesis by Primary Cultures of Human Kidney Tubular Epithelial Cells Is Modified by Glucose Availability Open
Coagulopathies common to patients with diabetes and chronic kidney disease (CKD) are not fully understood. Fibrin deposits in the kidney suggest the local presence of clotting factors including tissue factor (TF). In this study, we investi…
View article: PAR2 Activation on Human Kidney Tubular Epithelial Cells Induces Tissue Factor Synthesis, That Enhances Blood Clotting
PAR2 Activation on Human Kidney Tubular Epithelial Cells Induces Tissue Factor Synthesis, That Enhances Blood Clotting Open
Coagulation abnormalities and increased risk of atherothrombosis are common in patients with chronic kidney diseases (CKD). Mechanisms that alter renal hemostasis and lead to thrombotic events are not fully understood. Here we show that ac…
View article: Development of a Biomarker Panel to Distinguish Risk of Progressive Chronic Kidney Disease
Development of a Biomarker Panel to Distinguish Risk of Progressive Chronic Kidney Disease Open
Chronic kidney disease (CKD) patients typically progress to kidney failure, but the rate of progression differs per patient or may not occur at all. Current CKD screening methods are sub-optimal at predicting progressive kidney function de…