Tytti Heinonen
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View article: Author Correction: Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies
Author Correction: Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies Open
View article: Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies
Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies Open
View article: The EnvZ/OmpR Two-Component System Regulates the Antimicrobial Activity of TAT-RasGAP <sub>317-326</sub> and the Collateral Sensitivity to Other Antibacterial Agents
The EnvZ/OmpR Two-Component System Regulates the Antimicrobial Activity of TAT-RasGAP <sub>317-326</sub> and the Collateral Sensitivity to Other Antibacterial Agents Open
Antimicrobial peptides (AMP) are promising alternatives to classical antibiotics in the fight against antibiotic resistance. Resistance toward antimicrobial peptides can occur, but little is known about the mechanisms driving this phenomen…
View article: Trained Immunity Confers Prolonged Protection From Listeriosis
Trained Immunity Confers Prolonged Protection From Listeriosis Open
Trained immunity refers to the ability of the innate immune system exposed to a first challenge to provide an enhanced response to a secondary homologous or heterologous challenge. We reported that training induced with β-glucan one week b…
View article: High-dimensional immune phenotyping of blood cells by mass cytometry in patients infected with hepatitis C virus
High-dimensional immune phenotyping of blood cells by mass cytometry in patients infected with hepatitis C virus Open
View article: Bacterial surface properties influence the activity of the TAT-RasGAP317-326 antimicrobial peptide
Bacterial surface properties influence the activity of the TAT-RasGAP317-326 antimicrobial peptide Open
View article: The antimicrobial peptide TAT-RasGAP317-326 inhibits the formation and expansion of bacterial biofilms in vitro
The antimicrobial peptide TAT-RasGAP317-326 inhibits the formation and expansion of bacterial biofilms in vitro Open
These results underscore the potential use of TAT-RasGAP317-326 against biofilms and encourage further studies in the development of AMPs to treat biofilm-related infections.
View article: Bacterial surface properties influence the activity of the TAT-RasGAP<sub>317-326</sub> antimicrobial peptide
Bacterial surface properties influence the activity of the TAT-RasGAP<sub>317-326</sub> antimicrobial peptide Open
Antibiotic resistance is an increasing threat for public health, underscoring the need for new antibacterial agents. Antimicrobial peptides (AMPs) represent an alternative to classical antibiotics. TAT-RasGAP 317-326 is a recently describe…
View article: The antimicrobial peptide TAT-RasGAP<sub>317-326</sub>inhibits the formation and the expansion of bacterial biofilms<i>in vitro</i>
The antimicrobial peptide TAT-RasGAP<sub>317-326</sub>inhibits the formation and the expansion of bacterial biofilms<i>in vitro</i> Open
Biofilms are structured aggregates of bacteria embedded in a self-produced matrix. Pathogenic bacteria can form biofilms on surfaces and in tissues leading to nosocomial and chronic infections. While antibiotics are largely inefficient in …
View article: Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections
Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections Open
Background The innate immune system recalls a challenge to adapt to a secondary challenge, a phenomenon called trained immunity. Training involves cellular metabolic, epigenetic and functional reprogramming, but how broadly trained immunit…
View article: Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia
Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia Open
Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and SIRT3 target proteins involved in metabolic, proliferation and inflammation pathways and have been implicated in the pathogenesis of neurod…
View article: Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses
Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses Open
The sirtuins SIRT3 and SIRT5 are the main mitochondrial lysine deacetylase and desuccinylase, respectively. SIRT3 and SIRT5 regulate metabolism and redox homeostasis and have been involved in age-associated metabolic, neurologic and oncolo…
View article: Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections
Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections Open
Sirtuin 5 (SIRT5) is a member of the family of NAD+-dependent lysine/histone deacetylases. SIRT5 resides mainly in the mitochondria where it catalyzes deacetylation, demalonylation, desuccinylation, and deglutarylation of lysine…
View article: Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection Open
Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD+-dependent histone deacetylases. Sirtuins target histones and non-histone proteins according to their subcellular localization, influencing various biological pr…
View article: Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections Open
View article: Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo
Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo Open