Ulrich F. Wellner
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View article: Minimally Invasive vs Open Left Pancreatectomy for Resectable Pancreatic Cancer
Minimally Invasive vs Open Left Pancreatectomy for Resectable Pancreatic Cancer Open
Importance The DIPLOMA trial showed comparable radical resection rates after minimally invasive left pancreatectomy (MILP) and open left pancreatectomy (OLP) in patients with upfront resectable pancreatic cancer. Data on long-term overall …
View article: Oncologic outcomes and prognostic factors of colloid carcinoma of the pancreas – a retrospective real-world data analysis from the German cancer registry group of the society of German tumor centers
Oncologic outcomes and prognostic factors of colloid carcinoma of the pancreas – a retrospective real-world data analysis from the German cancer registry group of the society of German tumor centers Open
Background Colloid carcinoma (CC) is a rare subtype of pancreatic ductal adenocarcinoma (PDAC) characterized by mucin pools in over 80% of the tumor. This study compares the histopathology and outcomes of CC and not-otherwise specified PDA…
View article: Conversion of Robotic Distal Pancreatectomy
Conversion of Robotic Distal Pancreatectomy Open
Objective: The aim of this study was to identify risk factors for conversion and assess its consequences on clinical outcomes after robotic distal pancreatectomy (RPD). Summary of Background Data: RDP has gained popularity due to its lower…
View article: Adjuvant Chemotherapy Is Associated with Improved Survival in Advanced Ampullary Adenocarcinoma—A Population-Based Analysis by the German Cancer Registry Group
Adjuvant Chemotherapy Is Associated with Improved Survival in Advanced Ampullary Adenocarcinoma—A Population-Based Analysis by the German Cancer Registry Group Open
Introduction: Ampullary adenocarcinomas (AMPACs) represent rare malignant neoplasms arising in the Ampulla of Vater. Due to a lack of prospective studies and heterogeneous results from retrospective analyses, the outcomes of adjuvant chemo…
View article: THE ROLE OF SURGICAL FACTORS IN THE DEVELOPMENT OF POSTPANCREATODUODENECTOMY ACUTE PANCREATITIS IN PATIENTS AFTER PANCREATODUODENECTOMY
THE ROLE OF SURGICAL FACTORS IN THE DEVELOPMENT OF POSTPANCREATODUODENECTOMY ACUTE PANCREATITIS IN PATIENTS AFTER PANCREATODUODENECTOMY Open
Introduction. Pancreatoduodenectomy (PD) is the primary surgical approach for treating malignant and select benign tumors of the pancreas and periampullary region. One of the most serious complications following PD is post-pancreatectomy a…
View article: Impact of Single Freeze-Thaw Cycles on Serum Protein Stability: Implications for Clinical Biomarker Validation Using Mass Spectrometry
Impact of Single Freeze-Thaw Cycles on Serum Protein Stability: Implications for Clinical Biomarker Validation Using Mass Spectrometry Open
Background Validation of biomarkers for clinical diagnostics and therapy necessitates the availability of a substantial number of high-quality samples, along with a complete set of clinical data. Establishing standards for sample collectio…
View article: Perioperative and oncologic outcomes after total pancreatectomy and pancreatoduodenectomy for pancreatic head adenocarcinoma—A propensity score–matched analysis from the German Cancer Registry Group
Perioperative and oncologic outcomes after total pancreatectomy and pancreatoduodenectomy for pancreatic head adenocarcinoma—A propensity score–matched analysis from the German Cancer Registry Group Open
The results of this study show greater perioperative morbidity and mortality after total pancreatectomy compared with pancreatoduodenectomy for pancreatic head malignancy. Also, long-term survival was worse after total pancreatectomy. Thes…
View article: Impact of Neoadjuvant Therapy for Pancreatic Cancer: Transatlantic Trend and Postoperative Outcomes Analysis.
Impact of Neoadjuvant Therapy for Pancreatic Cancer: Transatlantic Trend and Postoperative Outcomes Analysis. Open
BACKGROUND: The introduction of modern chemotherapy a decade ago has led to increased use of neoadjuvant therapy (NAT) in patients with pancreatic ductal adenocarcinoma (PDAC). A recent North American study demonstrated increased use of NA…
View article: Ideal Outcome after Left Pancreatectomy in North America, Germany, the Netherlands, and Sweden
Ideal Outcome after Left Pancreatectomy in North America, Germany, the Netherlands, and Sweden Open
Background: Composite outcome measures aim to provide a more holistic view when determining the effectiveness and safety of surgical interventions. Recently, ‘Ideal Outcome’ (IO) harmonized the European and American composite outcome of pa…
View article: How to Predict Recurrence After Resection of Hepatocellular Carcinoma
How to Predict Recurrence After Resection of Hepatocellular Carcinoma Open
Predictors of recurrence following resection of HCC were identified. Prognostic scores traditionally used for patients receiving liver transplantation (AFP-score, RETREAT-score, CRS) were predictive also of recurrence after resection of HC…
View article: Competency, Proficiency, and Mastery
Competency, Proficiency, and Mastery Open
Objective: The aim of this study was to evaluate the different phases of the learning curve for robotic distal pancreatectomy (RDP) in international expert centers. Summary Background Data: RDP is an emerging minimally invasive approach; h…
View article: Routine Imaging or Symptomatic Follow-Up After Resection of Pancreatic Adenocarcinoma
Routine Imaging or Symptomatic Follow-Up After Resection of Pancreatic Adenocarcinoma Open
Importance International guidelines lack consistency in their recommendations regarding routine imaging in the follow-up after pancreatic resection for pancreatic ductal adenocarcinoma (PDAC). Consequently, follow-up strategies differ betw…
View article: ASO Visual Abstract: Surgical Outcome After Distal Pancreatectomy With and Without Portomesenteric Venous Resection in Patients with Pancreatic Adenocarcinoma
ASO Visual Abstract: Surgical Outcome After Distal Pancreatectomy With and Without Portomesenteric Venous Resection in Patients with Pancreatic Adenocarcinoma Open
Contains fulltext : 314914.pdf (Publisher’s version ) (Open Access)
View article: Transatlantic differences in the use and outcome of minimally invasive pancreatoduodenectomy: an international multi-registry analysis
Transatlantic differences in the use and outcome of minimally invasive pancreatoduodenectomy: an international multi-registry analysis Open
Background Minimally invasive pancreatoduodenectomy (MIPD) has emerged as an alternative to open pancreatoduodenectomy (OPD). However, the extent of variation in the use and outcomes of MIPD in relation to OPD among countries is unclear as…
View article: GERPACYST- The Trial Protocol Of The Prospective, Multicenter, Interdisciplinary German Pancreas Club Cyst Registry
GERPACYST- The Trial Protocol Of The Prospective, Multicenter, Interdisciplinary German Pancreas Club Cyst Registry Open
Background Cystic lesions of the pancreas have continued to present a clinical challenge for the past decades now. The increasing rate of detection, the lack of high-quality data on the natural biology of pancreatic cysts and the resulting…
View article: Surgical Outcome After Distal Pancreatectomy With and Without Portomesenteric Venous Resection in Patients with Pancreatic Adenocarcinoma: A Transatlantic Evaluation of Patients in North America, Germany, Sweden, and The Netherlands (GAPASURG)
Surgical Outcome After Distal Pancreatectomy With and Without Portomesenteric Venous Resection in Patients with Pancreatic Adenocarcinoma: A Transatlantic Evaluation of Patients in North America, Germany, Sweden, and The Netherlands (GAPASURG) Open
Background Pancreatic adenocarcinoma located in the pancreatic body might require a portomesenteric venous resection (PVR), but data regarding surgical risks after distal pancreatectomy (DP) with PVR are sparse. Insight into additional sur…
View article: 71342 - International differences in selection and outcome of minimally invasive and open distal pancreatectomy: a transatlantic analysis
71342 - International differences in selection and outcome of minimally invasive and open distal pancreatectomy: a transatlantic analysis Open
Introduction The safety and efficacy of minimally invasive distal pancreatectomy (MIDP) has been confirmed within randomized trials. Information regarding differences in patient selection and outcomes of MIDP and open distal pancreatectomy…
View article: International differences in the selection and outcome of minimally invasive and open distal pancreatectomy: A transatlantic analysis
International differences in the selection and outcome of minimally invasive and open distal pancreatectomy: A transatlantic analysis Open
Considerable disparities were seen in the use of minimally invasive distal pancreatectomy among 4 transatlantic registries of pancreatic surgery. Overall, minimally invasive distal pancreatectomy was associated with decreased mortality as …
View article: Oncological Outcomes and Patterns of Recurrence after the Surgical Resection of an Invasive Intraductal Papillary Mucinous Neoplasm versus Primary Pancreatic Ductal Adenocarcinoma: An Analysis from the German Cancer Registry Group of the Society of German Tumor Centers
Oncological Outcomes and Patterns of Recurrence after the Surgical Resection of an Invasive Intraductal Papillary Mucinous Neoplasm versus Primary Pancreatic Ductal Adenocarcinoma: An Analysis from the German Cancer Registry Group of the Society of German Tumor Centers Open
Background: Intraductal papillary mucinous neoplasms (IPMNs) are premalignant cystic neoplasms of the pancreas (CNPs), which can progress to invasive IPMN and pancreatic cancer. The available literature has shown controversial results rega…
View article: Monopolar electrocautery versus scalpel for pancreatic neck transection during open pancreatoduodenectomy: A retrospective, registry-based study
Monopolar electrocautery versus scalpel for pancreatic neck transection during open pancreatoduodenectomy: A retrospective, registry-based study Open
The study found no significant association between transection of the pancreatic parenchyma during open pancreatoduodenectomy with a scalpel compared with monopolar electrocautery regarding pancreatic fistula, postoperative bleeding, or ov…
View article: Intraoperative Wound Irrigation for the Prevention of Surgical Site Infection After Laparotomy
Intraoperative Wound Irrigation for the Prevention of Surgical Site Infection After Laparotomy Open
Importance Surgical site infections frequently occur after open abdominal surgery. Intraoperative wound irrigation as a preventive measure is a common practice worldwide, although evidence supporting this practice is lacking. Objective To …
View article: Near complete remission of an inoperable pancreatic acinar cell carcinoma after <scp>BRAF</scp>‐/<scp>MEK</scp>‐inhibitor treatment—A case report and review of the literature
Near complete remission of an inoperable pancreatic acinar cell carcinoma after <span>BRAF</span>‐/<span>MEK</span>‐inhibitor treatment—A case report and review of the literature Open
Introduction Pancreatic acinar cell carcinomas are rare malignant neoplasms. High‐quality evidence about the best treatment strategy is lacking. We present the case of a 52‐year‐old male with a BRAF V600E ‐mutated PACC who experienced a co…
View article: When Should Lymphadenectomy Be Performed in Non-Metastatic Pancreatic Neuroendocrine Tumors? A Population-Based Analysis of the German Clinical Cancer Registry Group
When Should Lymphadenectomy Be Performed in Non-Metastatic Pancreatic Neuroendocrine Tumors? A Population-Based Analysis of the German Clinical Cancer Registry Group Open
Background: Patient selection for lymphadenectomy remains a controversial aspect in the treatment of pancreatic neuroendocrine tumors (pNETs), given the growing importance of parenchyma-sparing resections and minimally invasive procedures.…
View article: RAC1b Collaborates with TAp73α-SMAD4 Signaling to Induce Biglycan Expression and Inhibit Basal and TGF-β-Driven Cell Motility in Human Pancreatic Cancer
RAC1b Collaborates with TAp73α-SMAD4 Signaling to Induce Biglycan Expression and Inhibit Basal and TGF-β-Driven Cell Motility in Human Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type characterized by a marked desmoplastic tumor stroma that is formed under the influence of transforming growth factor (TGF)-β. Data from mouse models of pancreatic c…