Lawrence Lee
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View article: Scenario Projections of Respiratory Syncytial Virus Hospitalizations Averted Due to New Immunizations
Scenario Projections of Respiratory Syncytial Virus Hospitalizations Averted Due to New Immunizations Open
Importance In 2023, new immunization strategies became available for preventing respiratory syncytial virus (RSV) hospitalizations in infants and older adults. Modeling studies to understand the population-level impact of their use are imp…
View article: Scenario projections of RSV hospitalizations averted due to new immunization programs in King County, Washington, October 2023 to May 2025
Scenario projections of RSV hospitalizations averted due to new immunization programs in King County, Washington, October 2023 to May 2025 Open
Importance In 2023 new immunization strategies became available for preventing respiratory syncytial virus (RSV)-associated hospitalizations in infants and older adults. Modeling studies to understand the population-level impact of their u…
View article: Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome
Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome Open
Background In acute respiratory distress syndrome (ARDS), respiratory drive often differs among patients with similar clinical characteristics. Readily observable factors like acid–base state, oxygenation, mechanics, and sedation depth do …
View article: Community respiratory viral metrics to inform masking in healthcare settings: A regional consensus approach
Community respiratory viral metrics to inform masking in healthcare settings: A regional consensus approach Open
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View article: PB0244 Analysis of Drug Related Problem Associated with Direct Oral Anticoagulants: Findings from a Medical Records Review by Pharmacists in a Large Teaching Hospital
PB0244 Analysis of Drug Related Problem Associated with Direct Oral Anticoagulants: Findings from a Medical Records Review by Pharmacists in a Large Teaching Hospital Open
Conclusion(s): long term use of contraceptives raises the risk for blood clots or incessantly bleeding as it causes changes in the PT, FIB, APTT and TT levels of Single women in Calabar.Contraceptive should only be used by recommendations …
View article: Two-year interim safety and efficacy of pegvaliase in Japanese adults with phenylketonuria
Two-year interim safety and efficacy of pegvaliase in Japanese adults with phenylketonuria Open
Phenylketonuria (PKU) is an inborn error of metabolism caused by deficiency of phenylalanine hydroxylase, resulting in high blood phenylalanine (Phe) concentrations with potential for impaired neurocognition. Pegvaliase, a pegylated recomb…
View article: Limited liver resections in the posterosuperior segments: international multicentre propensity score-matched and coarsened exact-matched analysis comparing the laparoscopic and robotic approaches
Limited liver resections in the posterosuperior segments: international multicentre propensity score-matched and coarsened exact-matched analysis comparing the laparoscopic and robotic approaches Open
Background Limited liver resections (LLRs) for tumours located in the posterosuperior segments of the liver are technically demanding procedures. This study compared outcomes of robotic (R) and laparoscopic (L) LLR for tumours located in t…
View article: Pragmatic adaptations of telehealth-delivered caregiver coaching for children with autism in the context of COVID-19: Perspectives from the United States and South Africa
Pragmatic adaptations of telehealth-delivered caregiver coaching for children with autism in the context of COVID-19: Perspectives from the United States and South Africa Open
When COVID-19 disrupted autism spectrum disorder research globally, many clinical trials of behavioral interventions pivoted to telehealth. Telehealth has the potential to increase geographic reach and improve racial/ethnic diversity in re…
View article: Meropenem and piperacillin-tazobactam levels for critical care patients duringempiric therapy
Meropenem and piperacillin-tazobactam levels for critical care patients duringempiric therapy Open
Meropenem and piperacillin
View article: Performance of Population Pharmacokinetic Models in Predicting Polymyxin B Exposures
Performance of Population Pharmacokinetic Models in Predicting Polymyxin B Exposures Open
Polymyxin B is the last line of defense in treating multidrug-resistant gram-negative bacterial infections. Dosing of polymyxin B is currently based on total body weight, and a substantial intersubject variability has been reported. We eva…
View article: A Randomized, Double‐Blind, Placebo‐ and Positive‐Controlled, 4‐Period Crossover Study of the Effects of Solriamfetol on QTcF Intervals in Healthy Participants
A Randomized, Double‐Blind, Placebo‐ and Positive‐Controlled, 4‐Period Crossover Study of the Effects of Solriamfetol on QTcF Intervals in Healthy Participants Open
Solriamfetol, a dopamine and norepinephrine reuptake inhibitor, is approved (United States and European Union; Sunosi) to treat excessive daytime sleepiness associated with narcolepsy (75‐150 mg/day) or obstructive sleep apnea (37.5‐150 mg…
View article: Pharmacodynamic effects of the K <sup>+</sup> binder patiromer in a novel chronic hyperkalemia model in spontaneously hypertensive rats
Pharmacodynamic effects of the K <sup>+</sup> binder patiromer in a novel chronic hyperkalemia model in spontaneously hypertensive rats Open
Currently described hyperkalemia (HK) animal models are typically acute and cause significant distress and mortality to the animals, warranting new approaches for studying chronic HK in a more appropriate clinical setting. Using the sponta…
View article: The Effect of Sample Site, Illness Duration, and the Presence of Pneumonia on the Detection of SARS-CoV-2 by Real-time Reverse Transcription PCR
The Effect of Sample Site, Illness Duration, and the Presence of Pneumonia on the Detection of SARS-CoV-2 by Real-time Reverse Transcription PCR Open
Background The performance of real-time reverse transcription polymerase chain reaction (rRT-PCR) for SARS-CoV-2 varies with sampling site(s), illness stage, and infection site. Methods Unilateral nasopharyngeal, nasal midturbinate, throat…
View article: Long-term study of the safety and maintenance of efficacy of solriamfetol (JZP-110) in the treatment of excessive sleepiness in participants with narcolepsy or obstructive sleep apnea
Long-term study of the safety and maintenance of efficacy of solriamfetol (JZP-110) in the treatment of excessive sleepiness in participants with narcolepsy or obstructive sleep apnea Open
Study Objectives To evaluate long-term safety and maintenance of efficacy of solriamfetol treatment for excessive daytime sleepiness in narcolepsy and obstructive sleep apnea (OSA). Methods Participants with narcolepsy or OSA who completed…
View article: P005 Long-term safety and efficacy of solriamfetol for excessive daytime sleepiness: an open-label extension randomised withdrawal trial
P005 Long-term safety and efficacy of solriamfetol for excessive daytime sleepiness: an open-label extension randomised withdrawal trial Open
Introduction Solriamfetol (formerly JZP-110), a dopamine and norepinephrine reuptake inhibitor, has been approved in the United States to improve wakefulness in adults with excessive daytime sleepiness (EDS) associated with narcolepsy (75–…
View article: 1578. Rifampicin Reduces Tedizolid Concentrations When Co-Administered in Healthy Volunteers
1578. Rifampicin Reduces Tedizolid Concentrations When Co-Administered in Healthy Volunteers Open
Background Tedizolid is an oxazolidinone used to treat skin and soft-tissue infections. Rifampicin is a rifamycin antibiotic which can also treat skin and soft-tissue infections, such as those caused by Staphylococcus aureus. Tedizolid and…
View article: 0601 Long-term Effects Of Solriamfetol On Quality Of Life In Participants With Excessive Daytime Sleepiness Associated With Narcolepsy Or Obstructive Sleep Apnea
0601 Long-term Effects Of Solriamfetol On Quality Of Life In Participants With Excessive Daytime Sleepiness Associated With Narcolepsy Or Obstructive Sleep Apnea Open
Solriamfetol, a selective dopamine and norepinephrine reuptake inhibitor, demonstrated long-term (up to 52 weeks) efficacy in participants with excessive daytime sleepiness (EDS) associated with narcolepsy or obstructive sleep apnea (OSA).…
View article: 0618 Weight Change Associated with Solriamfetol Treatment of Excessive Daytime Sleepiness in Participants with Narcolepsy or Obstructive Sleep Apnea
0618 Weight Change Associated with Solriamfetol Treatment of Excessive Daytime Sleepiness in Participants with Narcolepsy or Obstructive Sleep Apnea Open
Solriamfetol is a dopamine and norepinephrine reuptake inhibitor with demonstrated efficacy in treating excessive daytime sleepiness in narcolepsy and obstructive sleep apnea (OSA). Decreased appetite was a common adverse event (AE) in cli…
View article: Single‐Dose Pharmacokinetics and Safety of Solriamfetol in Participants With Normal or Impaired Renal Function and With End‐Stage Renal Disease Requiring Hemodialysis
Single‐Dose Pharmacokinetics and Safety of Solriamfetol in Participants With Normal or Impaired Renal Function and With End‐Stage Renal Disease Requiring Hemodialysis Open
Solriamfetol (JZP‐110), a selective dopamine and norepinephrine reuptake inhibitor with wake‐promoting effects, is renally excreted ∼90% unchanged within 48 hours. Effects of renal impairment and hemodialysis on the pharmacokinetics and sa…
View article: The Impact of Inflammatory Bowel Disease in Canada 2018: Direct Costs and Health Services Utilization
The Impact of Inflammatory Bowel Disease in Canada 2018: Direct Costs and Health Services Utilization Open
1. Forecasting models are necessary to predict the rising costs attributable to biologics associated with increasing prevalence of IBD, more frequent use of these medications, and the introduction of newer agents.2. Research into ways to m…
View article: The Impact of Inflammatory Bowel Disease in Canada 2018: Indirect Costs of IBD Care
The Impact of Inflammatory Bowel Disease in Canada 2018: Indirect Costs of IBD Care Open
Canadian-specific data on indirect health-related costs of IBD is sparse across all domains of indirect costs.In particular, the rates of absenteeism, presenteeism and premature retirement among IBD patients living in Canada require furthe…