U. Scheib
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View article: Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21 Open
USP21 belongs to the ubiquitin-specific protease (USP) subfamily of deubiquitinating enzymes (DUBs). Due to its relevance in tumor development and growth, USP21 has been reported as a promising novel therapeutic target for cancer treatment…
View article: Fine-tuning spermidine binding modes in the putrescine binding protein PotF
Fine-tuning spermidine binding modes in the putrescine binding protein PotF Open
A profound understanding of the molecular interactions between receptors and ligands is important throughout diverse research, such as protein design, drug discovery, or neuroscience. What determines specificity and how do proteins discrim…
View article: Optogenetic tools for manipulation of cyclic nucleotides functionally coupled to cyclic nucleotide‐gated channels
Optogenetic tools for manipulation of cyclic nucleotides functionally coupled to cyclic nucleotide‐gated channels Open
Background and Purpose The cyclic nucleotides cAMP and cGMP are ubiquitous second messengers regulating numerous biological processes. Malfunctional cNMP signalling is linked to diseases and thus is an important target in pharmaceutical re…
View article: Optogenetic tools for manipulation of cyclic nucleotides, functionally coupled to CNG-channels
Optogenetic tools for manipulation of cyclic nucleotides, functionally coupled to CNG-channels Open
Background and Purpose The cyclic nucleotides cAMP and cGMP are ubiquitous second messengers participating in the regulation of several biological processes. Interference of cNMP signalling is linked to multiple diseases and thus is an imp…
View article: Graphical Abstract: Angew. Chem. Int. Ed. 36/2020
Graphical Abstract: Angew. Chem. Int. Ed. 36/2020 Open
Oxidative CouplingIn their Communication on page 15468, C. Gerleve and A. Studer report the transition-metal-free oxidative cross-coupling of tetraarylborates to generate biaryls by using organic oxidants. ElectrofreezingElectrofreezing ex…
View article: Prey for the Proteasome: Targeted Protein Degradation—A Medicinal Chemist's Perspective
Prey for the Proteasome: Targeted Protein Degradation—A Medicinal Chemist's Perspective Open
Targeted protein degradation (TPD), the ability to control a proteins fate by triggering its degradation in a highly selective and effective manner, has created tremendous excitement in chemical biology and drug discovery within the past d…
View article: An unusual and vital protein with guanylate cyclase and P4-ATPase domains in a pathogenic protist
An unusual and vital protein with guanylate cyclase and P4-ATPase domains in a pathogenic protist Open
cGMP signaling is one of the master regulators of diverse functions in eukaryotes; however, its architecture and functioning in protozoans remain poorly understood. Herein, we report an exclusive guanylate cyclase coupled with N-terminal P…
View article: An unusual and physiologically vital protein with guanylate cyclase and P-type ATPase like domain in a pathogenic protist
An unusual and physiologically vital protein with guanylate cyclase and P-type ATPase like domain in a pathogenic protist Open
Cyclic GMP is considered as one of the master regulators of diverse functions in eukaryotes; its architecture and functioning in protozoans remain poorly understood however. We characterized an unusual and extra-large guanylate cyclase (47…
View article: Absorption and Emission Spectroscopic Investigation of Thermal Dynamics and Photo-Dynamics of the Rhodopsin Domain of the Rhodopsin-Guanylyl Cyclase from the Nematophagous Fungus Catenaria anguillulae
Absorption and Emission Spectroscopic Investigation of Thermal Dynamics and Photo-Dynamics of the Rhodopsin Domain of the Rhodopsin-Guanylyl Cyclase from the Nematophagous Fungus Catenaria anguillulae Open
The rhodopsin-guanylyl cyclase from the nematophagous fungus Catenaria anguillulae belongs to a recently discovered class of enzymerhodopsins and may find application as a tool in optogenetics. Here the rhodopsin domain CaRh of the rhodops…
View article: Absorption and emission spectroscopic investigation of thermal dynamics and photo-dynamics of the rhodopsin domain of the rhodopsin-guanylyl cyclase from the aquatic fungus Blastocladiella emersonii
Absorption and emission spectroscopic investigation of thermal dynamics and photo-dynamics of the rhodopsin domain of the rhodopsin-guanylyl cyclase from the aquatic fungus Blastocladiella emersonii Open
A new class of rhodopsins covalently linked to an enzymatic domain was discovered recently. A member of this class of enzymerhodopsins, the rhodopsin-guanylyl cyclase (RhGC) was identified in the aquatic fungus Blastocladiella emersonii (B…