Ulla Vogel
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View article: Fiber length and shape-dependent differences in hepatic nanomaterial localization in mice following pulmonary exposure
Fiber length and shape-dependent differences in hepatic nanomaterial localization in mice following pulmonary exposure Open
These findings demonstrate that the intrahepatic localization of nanomaterials is strongly influenced by fiber shape and dimensions.
View article: Toward a ToxAtlas of Carbon-Based Nanomaterials: Single-Cell RNA Sequencing Reveals Initiating Cell Circuits in Pulmonary Inflammation
Toward a ToxAtlas of Carbon-Based Nanomaterials: Single-Cell RNA Sequencing Reveals Initiating Cell Circuits in Pulmonary Inflammation Open
Understanding how nanomaterial properties drive acute lung inflammation is critical for the development of safer materials, but for low solubility carbon-based nanomaterials (CBNs) the initiation of the inflammatory response is still poorl…
View article: Air pollution and risk of rheumatoid arthritis – A Danish register-based cohort study
Air pollution and risk of rheumatoid arthritis – A Danish register-based cohort study Open
This study examined association between ambient air pollution and risk of rheumatoid arthritis (RA). Individuals born 1960-1999 from the nationwide Danish Occupational Cohort with eXposure data were linked to modeled exposure at the home a…
View article: Oil mists and vapours: A review of exposure and toxicity, with dose descriptors from inhalation studies
Oil mists and vapours: A review of exposure and toxicity, with dose descriptors from inhalation studies Open
Inhalation of oil mists and vapours may induce adverse effects. Here we review the literature on human exposure to oil mists and vapours and their toxicity following inhalation exposure. We collected data on inhalation of all types of oils…
View article: Per- and polyfluoroalkyl substances exposure in hexavalent chromium exposed workers and the effects of exposure mixtures on oxidative stress and genomic instability
Per- and polyfluoroalkyl substances exposure in hexavalent chromium exposed workers and the effects of exposure mixtures on oxidative stress and genomic instability Open
Hexavalent chromium (Cr(VI)) can induce oxidative stress, genomic instability, and epigenetic modifications. In occupational settings, Cr(VI)-exposed workers may also be exposed to other toxicants, such as elements besides Cr, and per- and…
View article: Effects of Different Interventions Aimed at Reducing Dermal and Internal Polycyclic Aromatic Hydrocarbon Exposure Among Firefighters
Effects of Different Interventions Aimed at Reducing Dermal and Internal Polycyclic Aromatic Hydrocarbon Exposure Among Firefighters Open
Firefighters are inherently exposed to soot and polycyclic aromatic hydrocarbons (PAHs) at work. In this repeated measures study, we assessed if three different interventions reduced PAH exposure. For each sub-study, the firefighters parti…
View article: Comparison of Lung Inflammatory and Transcriptional Responses in Mice and Rats Following Pulmonary Exposure to a Fiber Paradigm-Compatible and Non-Compatible MWCNT
Comparison of Lung Inflammatory and Transcriptional Responses in Mice and Rats Following Pulmonary Exposure to a Fiber Paradigm-Compatible and Non-Compatible MWCNT Open
Inhalation of multi-walled carbon nanotubes (MWCNTs) poses potential health risks due to their structural similarity to asbestos and their ability to induce chronic lung inflammation, fibrosis, and lung cancer in animal models. This study …
View article: Imogolite nanotube modifications impact pulmonary toxicity in mice: implications for safe and sustainable by design (SSbD)
Imogolite nanotube modifications impact pulmonary toxicity in mice: implications for safe and sustainable by design (SSbD) Open
Background Imogolite is a naturally occurring hollow aluminosilicate nanotube with potential for engineered applications due to its high aspect ratio, hydrophilicity, and polarization. However, these same features raise concerns about pote…
View article: Wisdom of Crowds for Supporting the Safety Evaluation of Nanomaterials.
Wisdom of Crowds for Supporting the Safety Evaluation of Nanomaterials. Open
The development of new approach methodologies (NAMs) to replace current in vivo testing for the safety assessment of engineered nanomaterials (ENMs) is hindered by the scarcity of validated experimental data for many ENMs. We introduce a f…
View article: Oxidative damage, genetic and epigenetic alterations in hexavalent chromium exposed workers - A cross-sectional study within the SafeChrom project
Oxidative damage, genetic and epigenetic alterations in hexavalent chromium exposed workers - A cross-sectional study within the SafeChrom project Open
Low-to-moderate Cr(VI) exposure was associated with higher oxidative stress, longer telomeres and epigenetic alterations, changes that previously have been linked to lung cancer risk. This study highlights the molecular impacts of Cr(VI) e…
View article: Pulmonary Toxicity of Long, Thick MWCNT and Very Long, Thin Carboxylated MWCNT Aerosols Following 28 Days Whole-Body Exposure
Pulmonary Toxicity of Long, Thick MWCNT and Very Long, Thin Carboxylated MWCNT Aerosols Following 28 Days Whole-Body Exposure Open
Pulmonary exposure to carbon nanotubes (CNTs) has been linked to a series of adverse respiratory effects in animal models, including inflammation, genotoxicity, fibrosis, and granuloma formation, the degree and characteristics of which are…
View article: Serum concentrations of per- and polyfluoroalkyl substances (PFAS) among men from the Danish fire services and Armed Forces
Serum concentrations of per- and polyfluoroalkyl substances (PFAS) among men from the Danish fire services and Armed Forces Open
Higher serum concentrations of PFHxS, PFHpS and PFOS among civilian airport firefighters likely reflected past occupational exposure to firefighting foam. Findings emphasized the importance of regulatory measures and substitution.
View article: Biokinetics of inhaled silver, gold, copper oxide, and zinc oxide nanoparticles: a review
Biokinetics of inhaled silver, gold, copper oxide, and zinc oxide nanoparticles: a review Open
The understanding of nanomaterial toxicity is aided by biokinetic information pointing to potential target organs. Silver (Ag), copper oxide (CuO), and zinc oxide (ZnO) are often referred to as soluble materials in the literature. In addit…
View article: The Impact of Carbon Nanotube Properties on Lung Pathologies and Atherosclerosis Through Acute Inflammation: a New AOP‐Anchored <i>in Silico</i> NAM
The Impact of Carbon Nanotube Properties on Lung Pathologies and Atherosclerosis Through Acute Inflammation: a New AOP‐Anchored <i>in Silico</i> NAM Open
In this study, a previously developed approach for creating a quantitative structure‐activity relationship model anchored in an Adverse Outcome Pathway framework (AOP‐anchored Nano‐QSAR) is employed to develop a novel model capable of pred…
View article: Integrative analyses of circulating microRNA expression profile in hexavalent chromium exposed workers – A cross-sectional study within the SafeChrom project
Integrative analyses of circulating microRNA expression profile in hexavalent chromium exposed workers – A cross-sectional study within the SafeChrom project Open
Our study suggests that low-to-moderate Cr(VI) exposure results in differential expression of lung-cancer-related miRNAs and associated target genes. Further studies are needed to validate our findings and clarify whether these changes pre…
View article: Toxicity of carbon nanomaterials: A model to predict ROS production from easily measurable surface characteristics
Toxicity of carbon nanomaterials: A model to predict ROS production from easily measurable surface characteristics Open
Toxicity pathways of engineered carbon nanomaterials, which have many and diverse industrial applications, include oxidative stress primarily due to the generation of reactive oxygen species (ROS). This study on 13 carbon black, 6 Graphene…
View article: Intratracheal instillation for the testing of pulmonary toxicity in mice—Effects of instillation devices and feed type on inflammation
Intratracheal instillation for the testing of pulmonary toxicity in mice—Effects of instillation devices and feed type on inflammation Open
Background Inhalation exposure is the gold standard when assessing pulmonary toxicity. However, it typically requires substantial amounts of test material. Intratracheal instillation is an alternative administration technique, where the te…
View article: Identification of PTGR2 inhibitors as a new therapy for diabetes and obesity
Identification of PTGR2 inhibitors as a new therapy for diabetes and obesity Open
Peroxisome proliferator-activated receptor γ (PPARγ) is a master transcriptional regulator of systemic insulin sensitivity and energy balance. The anti-diabetic drug thiazolidinediones (TZDs) are potent synthetic PPARγ ligands with undesir…
View article: Assessment of Polycyclic Aromatic Hydrocarbon Exposure in Trainee Firefighters Using PAH CALUX Bioassay
Assessment of Polycyclic Aromatic Hydrocarbon Exposure in Trainee Firefighters Using PAH CALUX Bioassay Open
This work investigated the application of a reporter gene bioassay in assessing polycyclic aromatic hydrocarbon (PAH) exposure in trainee firefighters. In the PAH CALUX bioassay, the PAH-induced activation of the aryl hydrocarbon receptor …
View article: Oxide-Perovskites for Automotive Catalysts Biotransform and Induce Multicomponent Clearance and Hazard
Oxide-Perovskites for Automotive Catalysts Biotransform and Induce Multicomponent Clearance and Hazard Open
Oxide-perovskites designed for automotive catalysts contain multiple metal elements whose presence is crucial to achieving the targeted performance. They are highly stable in exhaust operating conditions; however, little is known about the…
View article: Absence of genotoxicity following pulmonary exposure to metal oxides of copper, tin, aluminum, zinc, and titanium in mice
Absence of genotoxicity following pulmonary exposure to metal oxides of copper, tin, aluminum, zinc, and titanium in mice Open
Inhalation of nanosized metal oxides may occur at the workplace. Thus, information on potential hazardous effects is needed for risk assessment. We report an investigation of the genotoxic potential of different metal oxide nanomaterials. …