Ebele Uche
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View article: Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association?
Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association? Open
Introduction Systemic lupus erythematosus (SLE) and sickle cell disease (SCD) are distinct multisystemic diseases that commonly affect blacks. There are few reports of their co-existence in Western literature and a paucity of reports in Su…
View article: Protein S activity in sickle cell anaemia patients in steady state and crisis
Protein S activity in sickle cell anaemia patients in steady state and crisis Open
Background: In sickle cell anaemia, there is an ever-present risk for haemostatic abnormalities which may result in reduced levels of naturally occurring coagulation inhibitors. Protein S is a Vitamin-K dependent, γ-carboxy glutamic acid-c…
View article: Evaluation of serum folate, vitamin B12 and homocysteine among blood donors in Lagos State University teaching hospital, Lagos, Nigeria
Evaluation of serum folate, vitamin B12 and homocysteine among blood donors in Lagos State University teaching hospital, Lagos, Nigeria Open
Background: Folate, vitamin B12 deficiency and hyperhomocysteinaemia have been reported as important risk factors for the development of cardiovascular events and ischaemic stroke. These vitamin deficiencies are also implicated in the path…
View article: Ferritin and transferrin levels of the elderly population at Lagos State university teaching hospital, Ikeja, Lagos, Nigeria
Ferritin and transferrin levels of the elderly population at Lagos State university teaching hospital, Ikeja, Lagos, Nigeria Open
Background: The elderly have limited regenerative abilities thus predisposing them to various diseases. Measuring both serum ferritin and transferrin serve as biomarkers of iron deficiency. This study, using enzyme-linked immunosorbent ass…
View article: Health related quality of life among adults living with sickle cell disease in Lagos, Nigeria
Health related quality of life among adults living with sickle cell disease in Lagos, Nigeria Open
Background: Sickle cell disease (SCD) is an inherited haemoglobinopathy which involves the inheritance of haemoglobin S with any other abnormal haemoglobin from both parents. Health related quality of life (HRQOL) provides the patient’s vi…
View article: Red cell membrane protein abnormalities as defined by sds-page among patients with anemia in a West African region hospital practice.
Red cell membrane protein abnormalities as defined by sds-page among patients with anemia in a West African region hospital practice. Open
One in ten patients with mild anemia and abnormal red cell indices in clinical practice may be having hereditary red cell membrane protein defect. Presence of raised reticulocyte count, family history of mild anemia, increased red cell dis…
View article: Red cell membrane protein abnormalities as defined by sds-page among patients with anaemia in a west african region hospital practice
Red cell membrane protein abnormalities as defined by sds-page among patients with anaemia in a west african region hospital practice Open
Background: Erythrocytes require an ability to deform and withstand shear stress while negotiating microcirculation. These properties are largely due to their excess surface area per volume and the characteristics of the membrane’s protein…
View article: Superoxide dismutase activity in sickle cell anemia patients during crisis and in steady State
Superoxide dismutase activity in sickle cell anemia patients during crisis and in steady State Open
INTRODUCTION: Sickle cell anemia is associated with intense oxidative stress, and optimal antioxidant levels are essential to prevent continuous oxidant tissue damage. The role of oxidant damage to red blood cells in sickle cell anemia (SC…
View article: Methylene tetrahydrofolate reductase gene mutation in sickle cell anaemia patients in Lagos, Nigeria
Methylene tetrahydrofolate reductase gene mutation in sickle cell anaemia patients in Lagos, Nigeria Open
The prevalence of MTHFR C677T was higher than A1298C mutations among sickle cell anaemia subjects.
View article: <p>Serum homocysteine and disease severity in sickle cell anemia patients in Lagos</p>
Serum homocysteine and disease severity in sickle cell anemia patients in Lagos Open
Purpose: Hypercoagulability in sickle cell anemia (SCA) may be responsible for the increased development of vascular occlusion in certain organs as well as acute pain episodes. The causes of hypercoagulability in SCA are multifactorial and…
View article: The prevalence of occult hepatitis B infection among blood donors in Lagos, Nigeria
The prevalence of occult hepatitis B infection among blood donors in Lagos, Nigeria Open
The low prevalence (3%) of occult HBV seen in our study does not make it cost-effective to routinely screen blood donors or the general population for HBV infection using DNA polymerase chain reaction.
View article: Pentazocine addiction among sickle cell disease patients and perception of its use among health-care workers
Pentazocine addiction among sickle cell disease patients and perception of its use among health-care workers Open
BACKGROUND: Prolonged use of pentazocine in sickle cell disease (SCD) because of chronic pain may result in mental dependence (addiction) and/or physical dependence leading to withdrawal symptoms on suddenly stopping its use. This study wa…
View article: On artherogenic index of plasma in sickle cell anaemia patients
On artherogenic index of plasma in sickle cell anaemia patients Open
AIP value is higher in sickle cell anaemia than controls, the former have lower mean values of TC, HDL and LDL and higher mean values of TG and VLDL.
View article: A Comparative Study of Serum Ferritin Levels Among Unfit and Fit Blood Donors
A Comparative Study of Serum Ferritin Levels Among Unfit and Fit Blood Donors Open
Although serum ferritin depletion appears to be higher in the unfit blood donors, the use of serum ferritin as an index for the screening and determination of PDBs' fitness requires further evaluation.
View article: An assessment of knowledge, awareness, and attitude of undergraduates toward sickle cell disease in Lagos, Nigeria
An assessment of knowledge, awareness, and attitude of undergraduates toward sickle cell disease in Lagos, Nigeria Open
The awareness of SCD among the students is high but this awareness did not translate to good overall knowledge about the disease. This underscores the importance of increased public health education on SCD, in order to increase the knowled…
View article: Electrocardiographic Study in Adult Homozygous Sickle Cell Disease Patients in Lagos, Nigeria
Electrocardiographic Study in Adult Homozygous Sickle Cell Disease Patients in Lagos, Nigeria Open
Background . This study sought to identify the pattern of electrocardiographic changes in steady state adult sickle cell anaemia. Methods. A case-control, cross-sectional study was conducted amongst sickle cell patients attending the sickl…
View article: Impact of HIV Infection and Zidovudine Therapy on RBC Parameters and Urine Methylmalonic Acid Levels
Impact of HIV Infection and Zidovudine Therapy on RBC Parameters and Urine Methylmalonic Acid Levels Open
Background . Anaemia is a common complication of human immunodeficiency virus (HIV) infection. The aim of this study was to investigate the impact of HIV infection and zidovudine on red blood cells (RBC) parameters and urine methylmalonic …