Prateek Kumar
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View article: Signal Peptide of Human Serum Albumin (residues 1–18) Forms Amyloid-like Aggregates
Signal Peptide of Human Serum Albumin (residues 1–18) Forms Amyloid-like Aggregates Open
Signal peptides (SPs) are essential tools for sorting or translocating synthesized proteins. However, except for a few examples, their studies in isolation are quite limited. Here, we asked a question about the aggregation propensity of si…
View article: Attenuation of c-Myc expression in breast cancer by hesperidin-mediated stabilization of its promoter proximal G quadruplex region
Attenuation of c-Myc expression in breast cancer by hesperidin-mediated stabilization of its promoter proximal G quadruplex region Open
The G-Quadruplex (G4) silencer element (Pu-27), an epigenetic regulator located upstream of the c-Myc promoter, when stabilized and restored to its basal expression, presents a potential avenue for effective anticancer therapy. This study …
View article: Widespread amyloid aggregates formation by Zika virus proteins and peptides
Widespread amyloid aggregates formation by Zika virus proteins and peptides Open
Viral pathogenesis typically involves numerous molecular mechanisms. Protein aggregation is a relatively unknown characteristic of viruses, despite the fact that viral proteins have been shown to form terminally misfolded forms. Zika virus…
View article: Signal Peptide of Human Serum Albumin (residues 1-18) Forms Amyloid-like Aggregates
Signal Peptide of Human Serum Albumin (residues 1-18) Forms Amyloid-like Aggregates Open
Signal peptides (SPs) are essential tools in sorting or translocating the synthesized proteins. However, except few examples, their studies in isolation are quite limited. Here we asked a question of the aggregation propensity of signal pe…
View article: Coronaviruses spike glycoprotein endodomains: The sequence and structure‐based comprehensive study
Coronaviruses spike glycoprotein endodomains: The sequence and structure‐based comprehensive study Open
Any protein's flexibility or region makes it available to interact with many biomolecules in the cell. Specifically, such interactions in viruses help them to perform more functions despite having a smaller genome. Therefore, these flexibl…
View article: Japanese Encephalitis Virus: A pan-proteome analysis for aggregation propensities and in vitro validation with Capsid anchor and 2K peptide
Japanese Encephalitis Virus: A pan-proteome analysis for aggregation propensities and in vitro validation with Capsid anchor and 2K peptide Open
Japanese encephalitis infection is a vector-borne disease caused by the flavivirus Japanese encephalitis virus (JEV). It is responsible for severe brain infections in humans worldwide. Given the ubiquitous nature of complications and tropi…
View article: Effect of Organic Manures and Nano Zinc on Growth and Yield of Baby Corn (Zea mays L.)
Effect of Organic Manures and Nano Zinc on Growth and Yield of Baby Corn (Zea mays L.) Open
A field experiment was conducted during kharif 2022 at CRF (Crop Research Farm), Department of Agronomy, SHUATS, Prayagraj, (UP). To study the “Effect of organic manures and Nano zinc on growth and yield of baby corn”. The soil of the expe…
View article: Coronaviruses Spike glycoprotein endodomains: the sequence and structure-based comprehensive study
Coronaviruses Spike glycoprotein endodomains: the sequence and structure-based comprehensive study Open
The flexibility of proteins makes them available to interact with many biomolecules in the cell. Specifically, such interactions in viruses help them to perform more functions despite having a smaller genome. Therefore, these flexible regi…
View article: Met58 and di-acidic motif located at C-terminal region of SARS-CoV-2 ORF6 plays a crucial role in its structural conformations
Met58 and di-acidic motif located at C-terminal region of SARS-CoV-2 ORF6 plays a crucial role in its structural conformations Open
Despite being mostly neglected in structural biology, the C-terminal Regions (CTRs) are studied to be multifunctional in humans as well as in viruses. Their role in cellular processes such as trafficking, protein-protein interactions, and …
View article: Structure-based virtual screening approach reveals natural multi-target compounds for the development of antimalarial drugs to combat drug resistance
Structure-based virtual screening approach reveals natural multi-target compounds for the development of antimalarial drugs to combat drug resistance Open
Compared to the previous year, there has been an increase of nearly 2 million malaria cases in 2021. The emergence of drug-resistant strains of Plasmodium falciparum, the most deadly malaria parasite, has led to a decline in the eff…
View article: Correlation between value of Hba1c and degree of sensorineural hearing loss in type 2 diabetics
Correlation between value of Hba1c and degree of sensorineural hearing loss in type 2 diabetics Open
Background: Diabetes mellitus and hearing loss are common public health problems. Sensorineural hearing loss in Type 2 diabetes mellitus patients is an underestimated complication. The aim was to study the correlation between level of HbA1…
View article: Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes Open
View article: SARS-CoV-2–encoded ORF8 protein possesses complement inhibitory properties
SARS-CoV-2–encoded ORF8 protein possesses complement inhibitory properties Open
Hyperactivation of the complement system, a major component of innate immunity, has been recognized as one of the core clinical features in severe covid-19 patients. However, how the virus escapes the targeted elimination by the network of…
View article: Discovery And Characterization of Small Molecule Inhibitors of Zika Virus Replication
Discovery And Characterization of Small Molecule Inhibitors of Zika Virus Replication Open
Zika virus (ZIKV) is a flavivirus, and ZIKV infections in the past 15 years have been linked to Guillain-Barre syndrome and severe complications during pregnancy associated with congenital Zika syndrome. There are no approved therapies or …
View article: Investigating the folding dynamics of NS2B protein of Zika virus
Investigating the folding dynamics of NS2B protein of Zika virus Open
NS2B protein of the Zika virus acts as a co-factor for NS3 protease where only the cytosolic domain of NS2B is sufficient for the protease activity. At the same time, NS2B also involves in remodeling the NS3 protease structure. In isolatio…
View article: THE IMPACT OF COVID19 ON RURAL COMMUNITIES
THE IMPACT OF COVID19 ON RURAL COMMUNITIES Open
This research paper talks about how covid19 affected rural communities in India and how they recovered from it. As the rural healthcare in India was not prepared for containing the covid19 transmissions, especially in densely populated nor…
View article: Acute Rejection following COVID-19 Vaccine (AstraZeneca)
Acute Rejection following COVID-19 Vaccine (AstraZeneca) Open
View article: Inflammatory cell distribution accrediting Th2 inflammation in Sinonasal polyp in Indian Population
Inflammatory cell distribution accrediting Th2 inflammation in Sinonasal polyp in Indian Population Open
The pathophysiology of Chronic Rhino-Sinusitis with Nasal Polyposis (CRSwNP) showed distinct ethnic and geographic differences whereas the Western Caucasian population revealed Th2 eosinophilic inflammation in contrary to the Asian Mongoli…
View article: Structural dynamics of Zika Virus NS1 via a reductionist approach reveal the disordered nature of its beta roll domain in isolation
Structural dynamics of Zika Virus NS1 via a reductionist approach reveal the disordered nature of its beta roll domain in isolation Open
Flavivirus Non-structural 1 (NS1) protein performs multiple functions such as host immune evasion, interaction with complement system factors, membrane rearrangement, etc. Therefore, it is highly plausible that significant structural and f…
View article: Functional inhibition of c-Myc using novel inhibitors identified through “hot spot” targeting
Functional inhibition of c-Myc using novel inhibitors identified through “hot spot” targeting Open
View article: The aggregation potential of Zika virus proteome
The aggregation potential of Zika virus proteome Open
The ability of human encoded soluble proteins to convert into amyloid fibrils is now recognized as a generic phenomenon in several human illnesses. Typically, such disease causal proteins/peptides consist of aggregation-prone regions (APR)…
View article: Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal
Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal Open
SARS-CoV-2 NSP1 is believed to be a potential drug target. Its C-terminal region which associates with ribosomal subunit has shown good binding with an anticancer drug, Mitoxantrone.
View article: Transactivation domain of Adenovirus Early Region 1A (E1A): Investigating folding dynamics and aggregation
Transactivation domain of Adenovirus Early Region 1A (E1A): Investigating folding dynamics and aggregation Open
Transactivation domain of Adenovirus Early region 1A (E1A) oncoprotein is an intrinsically disordered molecular hub protein. It is involved in binding to different domains of human cell transcriptional co-activators such as retinoblastoma …
View article: Investigating the conformational dynamics of Zika virus NS4B protein
Investigating the conformational dynamics of Zika virus NS4B protein Open
Zika virus (ZIKV) NS4B protein is a membranotropic protein having multifunctional roles such as evasion of host-immune system, and induction of host membrane rearrangement for viral genome replication and processing of polyprotein. Despite…
View article: Microsecond simulations and CD spectroscopy reveals the intrinsically disordered nature of SARS-CoV-2 spike-C-terminal cytoplasmic tail (residues 1242–1273) in isolation
Microsecond simulations and CD spectroscopy reveals the intrinsically disordered nature of SARS-CoV-2 spike-C-terminal cytoplasmic tail (residues 1242–1273) in isolation Open
View article: Investigating the conformational dynamics of SARS-CoV-2 NSP6 protein with emphasis on non-transmembrane 91–112 & 231–290 regions
Investigating the conformational dynamics of SARS-CoV-2 NSP6 protein with emphasis on non-transmembrane 91–112 & 231–290 regions Open
View article: Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal
Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal Open
One of the major virulence factors of SARS-CoV-2, NSP1, is a vital drug target due to its role in host immune evasion through multiple pathways. NSP1 protein is associated with inhibiting host mRNA translation by binding to the small subun…
View article: A Study on the Coronavirus Pandemic and its Impact on the Indian Education Sector & Online Learning Pertaining to the Students
A Study on the Coronavirus Pandemic and its Impact on the Indian Education Sector & Online Learning Pertaining to the Students Open
The recent COVID -19, Coronavirus outbreak has brought the entire world at a standstill. various industries , businesses , households have been brought to its knees , on of these sectors that this study focuses is the Indian education sect…
View article: Investigating the conformational dynamics of SARS-CoV-2 NSP6 protein with emphasis on non-transmembrane 91-112 & 231-290 regions
Investigating the conformational dynamics of SARS-CoV-2 NSP6 protein with emphasis on non-transmembrane 91-112 & 231-290 regions Open
The NSP6 protein of SARS-CoV-2 is a transmembrane protein, with some regions lying outside the membrane. Besides, a brief role of NSP6 in autophagosome formation, this is not studied significantly. Also, there is no structural information …
View article: Analysis of the dark proteome of Chandipura virus reveals maximum propensity for intrinsic disorder in phosphoprotein
Analysis of the dark proteome of Chandipura virus reveals maximum propensity for intrinsic disorder in phosphoprotein Open