Ugomma C. Eze
YOU?
Author Swipe
View article: Short cell cycle duration is a phenotype of human epidermal stem cells
Short cell cycle duration is a phenotype of human epidermal stem cells Open
Background A traditional view is that stem cells (SCs) divide slowly. Meanwhile, both embryonic and pluripotent SCs display a shorter cell cycle duration (CCD) in comparison to more committed progenitors (CPs). Methods We examined the in v…
View article: Tropism of SARS-CoV-2 for human cortical astrocytes
Tropism of SARS-CoV-2 for human cortical astrocytes Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of vital organ systems, with particularly severe impact on respiratory function. Neurological symptoms, which r…
View article: An atlas of cortical arealization identifies dynamic molecular signatures
An atlas of cortical arealization identifies dynamic molecular signatures Open
The human brain is subdivided into distinct anatomical structures, including the neocortex, which in turn encompasses dozens of distinct specialized cortical areas. Early morphogenetic gradients are known to establish early brain regions a…
View article: An Atlas of Cortical Arealization Identifies Dynamic Molecular Signatures
An Atlas of Cortical Arealization Identifies Dynamic Molecular Signatures Open
The human brain is subdivided into distinct anatomical structures. The neocortex, one of these structures, enables higher-order sensory, associative, and cognitive functions, and in turn encompasses dozens of distinct specialized cortical …
View article: Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia Open
The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To characterize the earliest stages of human brain development, we per…
View article: Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes
Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of vital organ systems, with particularly severe impact on respiratory function. It proves fatal for one percen…
View article: Single-Cell Atlas of Early Human Brain Development Highlights Heterogeneity of Human Neuroepithelial Cells and Early Radial Glia
Single-Cell Atlas of Early Human Brain Development Highlights Heterogeneity of Human Neuroepithelial Cells and Early Radial Glia Open
The human cortex is comprised of diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To characterize the earliest stages of human brain development, …
View article: 3D Epigenomic Characterization Reveals Insights Into Gene Regulation and Lineage Specification During Corticogenesis
3D Epigenomic Characterization Reveals Insights Into Gene Regulation and Lineage Specification During Corticogenesis Open
Lineage-specific epigenomic changes during human corticogenesis have previously remained elusive due to challenges with tissue heterogeneity and sample availability. Here, we analyze cis-regulatory chromatin interactions, open chromatin re…