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View article: Text mining for contexts and relationships in cancer genomics literature
Text mining for contexts and relationships in cancer genomics literature Open
Motivation Scientific advances build on the findings of existing research. The 2001 publication of the human genome has led to the production of huge volumes of literature exploring the context-specific functions and interactions of genes.…
View article: Data from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Data from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Hepatocellular carcinoma (HCC) is rated as the fifth most common malignancy and third in cancer-related deaths worldwide. Statins, HMG-CoA reductase inhibitors, are potent cholesterol-lowering drugs, and recent epidemiologic evidence sugge…
View article: Supplementary Data Figure 1 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Supplementary Data Figure 1 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Overexpression of HBx protein increases pAkt level in Huh7 cells.
View article: Supplementary Data Figure 2 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Supplementary Data Figure 2 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Atorvastatin decreases proliferation in hepatocytes.
View article: Supplemental Legends from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Supplemental Legends from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Supplemental Legends
View article: Supplemental Legends from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Supplemental Legends from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Supplemental Legends
View article: Data from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Data from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Hepatocellular carcinoma (HCC) is rated as the fifth most common malignancy and third in cancer-related deaths worldwide. Statins, HMG-CoA reductase inhibitors, are potent cholesterol-lowering drugs, and recent epidemiologic evidence sugge…
View article: Supplementary Data Figure 1 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Supplementary Data Figure 1 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Overexpression of HBx protein increases pAkt level in Huh7 cells.
View article: Supplementary Data Figure 2 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Supplementary Data Figure 2 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Atorvastatin decreases proliferation in hepatocytes.
View article: Data from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer
Data from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer Open
Tight junctions (TJ) act as hubs for intracellular signaling pathways controlling epithelial cell fate and function. Deregulation of TJ is a hallmark of epithelial–mesenchymal transition (EMT), which contributes to carcinoma progression an…
View article: Supplementary Figures S1-S9 from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer
Supplementary Figures S1-S9 from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer Open
This file includes supplementary figures S1-S9: Figure S1. Immunofluorescence and western blot results showing differences in CXADR expression between EpH4, EpRas and EpXT cells. Figure S2. Western blots showing how incubatino with an AKT …
View article: Supplementary Figures S1-S9 from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer
Supplementary Figures S1-S9 from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer Open
This file includes supplementary figures S1-S9: Figure S1. Immunofluorescence and western blot results showing differences in CXADR expression between EpH4, EpRas and EpXT cells. Figure S2. Western blots showing how incubatino with an AKT …
View article: Supplementary Tables from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer
Supplementary Tables from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer Open
This supplementary information includes 3 supplementary tables. Table S1. List of antibodies. Table S2. List of plasmids. Table S3. List of human tumor samples.
View article: Data from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer
Data from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer Open
Tight junctions (TJ) act as hubs for intracellular signaling pathways controlling epithelial cell fate and function. Deregulation of TJ is a hallmark of epithelial–mesenchymal transition (EMT), which contributes to carcinoma progression an…
View article: Supplementary Tables from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer
Supplementary Tables from CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer Open
This supplementary information includes 3 supplementary tables. Table S1. List of antibodies. Table S2. List of plasmids. Table S3. List of human tumor samples.
View article: ATX-LPA-Dependent Nuclear Translocation of Endonuclease G in Respiratory Epithelial Cells: A New Mode Action for DNA Damage Induced by Crystalline Silica Particles
ATX-LPA-Dependent Nuclear Translocation of Endonuclease G in Respiratory Epithelial Cells: A New Mode Action for DNA Damage Induced by Crystalline Silica Particles Open
Crystalline silica particles (CSi) are an established human carcinogen, but it is not clear how these particles cause necessary mutations. A well-established scenario includes inflammation caused by retained particles in the bronchioles, a…
View article: Application of Text Mining in Risk Assessment of Chemical Mixtures: A Case Study of Polycyclic Aromatic Hydrocarbons (PAHs)
Application of Text Mining in Risk Assessment of Chemical Mixtures: A Case Study of Polycyclic Aromatic Hydrocarbons (PAHs) Open
BACKGROUND: Cancer risk assessment of complex exposures, such as exposure to mixtures of polycyclic aromatic hydrocarbons (PAHs), is challenging due to the diverse biological activities of these compounds. With the help of text mining (TM)…
View article: Crystalline silica particles induce DNA damage in respiratory epithelium by ATX secretion and Rac1 activation
Crystalline silica particles induce DNA damage in respiratory epithelium by ATX secretion and Rac1 activation Open
Autotaxin (ATX) and its product lysophosphatidic acid (LPA) have been implicated in lung fibrosis and cancer. We have studied their roles in DNA damage induced by carcinogenic crystalline silica particles (CSi). In an earlier study on bron…
View article: PTEN and PHLPP crosstalk in cancer cells and in TGFβ-activated stem cells
PTEN and PHLPP crosstalk in cancer cells and in TGFβ-activated stem cells Open
Characterization of Akt regulation may lead to a better understanding of tumor development and to novel strategies for treatment.
View article: Genotoxic damage in a Bolivian agricultural population exposed to a mixture of pesticides
Genotoxic damage in a Bolivian agricultural population exposed to a mixture of pesticides Open
TPS 792: Occupational health 2, Exhibition Hall, Ground floor, August 27, 2019, 3:00 PM - 4:30 PM Pesticides are well-known chemicals that can increase the risk to develop cancer by induction of DNA damage and oxidative stress, especially …
View article: Increased levels of genotoxic damage in a Bolivian agricultural population exposed to mixtures of pesticides
Increased levels of genotoxic damage in a Bolivian agricultural population exposed to mixtures of pesticides Open
During the past decades, farmers in low to middle-income countries have increased their use of pesticides, and thereby the risk of being exposed to potentially genotoxic chemicals that can cause adverse health effects. Here, the aim was to…
View article: The Water Extract of Juniperus communis L. Induces Cell Death and Sensitizes Cancer Cells to Cytostatic Drugs through p53 and PI3K/Akt Pathways
The Water Extract of Juniperus communis L. Induces Cell Death and Sensitizes Cancer Cells to Cytostatic Drugs through p53 and PI3K/Akt Pathways Open
Juniper (Juniperus communis L.) is a northern coniferous plant generally used as a spice and for nutritional purposes in foods and drinks. It was previously reported that juniper extract (JE) affects p53 activity, cellular stress, and gene…
View article: Pesticide exposure among Bolivian farmers: associations between worker protection and exposure biomarkers
Pesticide exposure among Bolivian farmers: associations between worker protection and exposure biomarkers Open
The use of pesticides has increased during the past decades, also increasing the risk of exposure to toxic pesticides that can cause detrimental health effects in the future. This is of special concern among farmers in low-to-middle-income…
View article: CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer
CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial–Mesenchymal Plasticity in Breast Cancer Open
Tight junctions (TJ) act as hubs for intracellular signaling pathways controlling epithelial cell fate and function. Deregulation of TJ is a hallmark of epithelial–mesenchymal transition (EMT), which contributes to carcinoma progression an…
View article: LION LBD: a literature-based discovery system for cancer biology
LION LBD: a literature-based discovery system for cancer biology Open
Motivation The overwhelming size and rapid growth of the biomedical literature make it impossible for scientists to read all studies related to their work, potentially leading to missed connections and wasted time and resources. Literature…
View article: ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage?
ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage? Open
Silica exposure is a common risk factor for lung cancer. It has been claimed that key elements in cancer development are activation of inflammatory cells that indirectly induce DNA damage and proliferative stimuli in respiratory epithelial…