Ullhas Kaarthi Moorthi
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View article: Deterministic early endosomal maturations emerge from a stochastic trigger-and-convert mechanism
Deterministic early endosomal maturations emerge from a stochastic trigger-and-convert mechanism Open
Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves a phosphoinositide-driven gain or loss of specific proteins on indivi…
View article: Deterministic Early Endosomal Maturations Emerge From a Stochastic Trigger-and-Convert Mechanism
Deterministic Early Endosomal Maturations Emerge From a Stochastic Trigger-and-Convert Mechanism Open
Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves phosphoinositide-driven gain or loss of specific proteins on individu…
View article: βIII-Tubulin Structural Domains Regulate Mitochondrial Network Architecture in an Isotype-Specific Manner
βIII-Tubulin Structural Domains Regulate Mitochondrial Network Architecture in an Isotype-Specific Manner Open
βIII-tubulin is a neuronal microtubule protein that is aberrantly expressed in epithelial cancers. The microtubule network is implicated in regulating the architecture and dynamics of the mitochondrial network, although the isotype-specifi…
View article: Ordered and Disordered Segments of Amyloid‐β Drive Sequential Steps of the Toxic Pathway
Ordered and Disordered Segments of Amyloid‐β Drive Sequential Steps of the Toxic Pathway Open
While the roles of intrinsically disordered protein domains in driving many interactions are increasingly well‐appreciated, the mechanism of toxicity of disease‐causing disordered proteins remains poorly understood. A prime example is Alzh…
View article: Rapid Whole Cell Imaging Reveals A Calcium-APPL1-Dynein Nexus That Regulates Cohort Trafficking of Stimulated EGF Receptors
Rapid Whole Cell Imaging Reveals A Calcium-APPL1-Dynein Nexus That Regulates Cohort Trafficking of Stimulated EGF Receptors Open
Multicellular life processes such as proliferation and differentiation depend on cell surface signaling receptors that bind ligands generally referred to as growth factors. Recently, it has emerged that the endosomal system provides rich s…