Ulrich H. Frey
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View article: Preoperative cognitive impairment predicts deep anaesthesia and higher postoperative pain in elderly patients: an observational study
Preoperative cognitive impairment predicts deep anaesthesia and higher postoperative pain in elderly patients: an observational study Open
Background The prevalence of cognitive impairment and its associated risks under general anaesthesia increases with age. This necessitates careful observation and mitigation of anaesthetic risk in elderly patients. While deeper anaesthetic…
View article: Association of intraoperative hypotension and acute kidney injury in noncardiac surgery patients: a post hoc secondary analysis of the EU HYPROTECT registry
Association of intraoperative hypotension and acute kidney injury in noncardiac surgery patients: a post hoc secondary analysis of the EU HYPROTECT registry Open
Purpose Previous cohort studies suggest that intraoperative hypotension is associated with acute kidney injury (AKI) in noncardiac surgical patients. We sought to ascertain that intraoperative hypotension is independently associated with A…
View article: Impact of glucocorticoid receptor polymorphism rs6198 on sepsis survival in a prospective multicenter cohort
Impact of glucocorticoid receptor polymorphism rs6198 on sepsis survival in a prospective multicenter cohort Open
The glucocorticoid receptor (GR), particularly its isoforms GRα and GRβ, plays a crucial role in modulating inflammatory responses. The rs6198 single nucleotide polymorphism (SNP) in the NR3C1 gene, which encodes GR, has been associated wi…
View article: Perioperative interdisciplinary optimisation of patients with heart failure undergoing non-cardiac surgery with intermediate or high surgical risk: the rationale and study protocol for the multicentre, randomised interventional PeriOP-CARE HF trial
Perioperative interdisciplinary optimisation of patients with heart failure undergoing non-cardiac surgery with intermediate or high surgical risk: the rationale and study protocol for the multicentre, randomised interventional PeriOP-CARE HF trial Open
Aim Chronic heart failure (HF) is a frequent comorbidity in elderly patients undergoing major non-cardiac surgery with increasing prevalence. This trial aims to evaluate a new interdisciplinary, multimodal and individually optimised treatm…
View article: Influence of Anesthetic Regimes on Extracellular Vesicles following Remote Ischemic Preconditioning in Coronary Artery Disease
Influence of Anesthetic Regimes on Extracellular Vesicles following Remote Ischemic Preconditioning in Coronary Artery Disease Open
Remote ischemic preconditioning (RIPC) reduces ischemia-reperfusion injury in aortocoronary bypass surgery, potentially via extracellular vesicles (EVs) and their micro-RNA content. Clinical data implicate that propofol might inhibit the c…
View article: Assessing SOFA score trajectories in sepsis using machine learning: A pragmatic approach to improve the accuracy of mortality prediction
Assessing SOFA score trajectories in sepsis using machine learning: A pragmatic approach to improve the accuracy of mortality prediction Open
Introduction An increasing amount of longitudinal health data is available on critically ill septic patients in the age of digital medicine, including daily sequential organ failure assessment (SOFA) score measurements. Thus, the assessmen…
View article: Protein Interaction Assessing Mitochondrial Biogenesis as a Next Generation Biomarker in Sepsis
Protein Interaction Assessing Mitochondrial Biogenesis as a Next Generation Biomarker in Sepsis Open
View article: The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion
The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion Open
Sepsis is a common life-threatening disease caused by dysregulated immune response and metabolic acidosis which lead to organ failure. An abnormal expression of aquaporins plays an important role in organ failure. Additionally, genetic var…
View article: AQP3 and AQP9—Contrary Players in Sepsis?
AQP3 and AQP9—Contrary Players in Sepsis? Open
Sepsis involves an immunological systemic response to a microbial pathogenic insult, leading to a cascade of interconnected biochemical, cellular, and organ–organ interaction networks. Potential drug targets can depict aquaporins, as they …
View article: Preoperative Midazolam and Patient-Centered Outcomes of Older Patients
Preoperative Midazolam and Patient-Centered Outcomes of Older Patients Open
Importance The effect of oral midazolam premedication on patient satisfaction in older patients undergoing surgery is unclear, despite its widespread use. Objective To determine the differences in global perioperative satisfaction in patie…
View article: Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis Open
Background Sepsis is one of the leading causes of death. Treatment attempts targeting the immune response regularly fail in clinical trials. As HCMV latency can modulate the immune response and changes the immune cell composition, we hypot…
View article: Influence of the Anesthetic Technique on Circulating Extracellular Vesicles in Bladder Cancer Patients Undergoing Radical Cystectomy: A Prospective, Randomized Trial
Influence of the Anesthetic Technique on Circulating Extracellular Vesicles in Bladder Cancer Patients Undergoing Radical Cystectomy: A Prospective, Randomized Trial Open
Anesthetics have been shown to alter tumor progression and seem to influence surgical cancer outcome. Circulating extracellular vesicles as mediators of intercellular communication are involved in cancer progression and may be influenced b…
View article: Hypoxemia of the lower limbs during robot‐assisted radical prostatectomy in Trendelenburg position
Hypoxemia of the lower limbs during robot‐assisted radical prostatectomy in Trendelenburg position Open
Objectives The objective of this study is to assess frequency and risk factors for intraoperative hypoxemia of the lower limbs during robot‐assisted radical prostatectomy (RARP). Trendelenburg position during RARP may contribute to hypoxem…
View article: COVID-19-ECMO mit Seltenheitswert: wenn Blutgruppe „0“ zum Problem wird
COVID-19-ECMO mit Seltenheitswert: wenn Blutgruppe „0“ zum Problem wird Open
View article: Hypotension Prediction Index and Incidence of Perioperative Hypotension: A Single-Center Propensity-Score-Matched Analysis
Hypotension Prediction Index and Incidence of Perioperative Hypotension: A Single-Center Propensity-Score-Matched Analysis Open
(1) Background: Intraoperative hypotension is common and is associated with increased morbidity and mortality. The Hypotension Prediction Index (HPI) is an advancement of arterial waveform analysis and allows preventive treatments. We used…
View article: Intraoperative hypotension when using hypotension prediction index software during major noncardiac surgery: a European multicentre prospective observational registry (EU HYPROTECT)
Intraoperative hypotension when using hypotension prediction index software during major noncardiac surgery: a European multicentre prospective observational registry (EU HYPROTECT) Open
View article: Publisher Correction: Mortality rates of severe COVID-19-related respiratory failure with and without extracorporeal membrane oxygenation in the Middle Ruhr Region of Germany
Publisher Correction: Mortality rates of severe COVID-19-related respiratory failure with and without extracorporeal membrane oxygenation in the Middle Ruhr Region of Germany Open
View article: Mortality rates of severe COVID-19-related respiratory failure with and without extracorporeal membrane oxygenation in the Middle Ruhr Region of Germany
Mortality rates of severe COVID-19-related respiratory failure with and without extracorporeal membrane oxygenation in the Middle Ruhr Region of Germany Open
The use of extracorporeal membrane oxygenation (ECMO) is discussed to improve patients’ outcome in severe COVID-19 with respiratory failure, but data on ECMO remains controversial. The aim of the study was to determine the characteristics …
View article: Quantification of left ventricular ejection fraction and cardiac output using a novel semi-automated echocardiographic method: a prospective observational study in coronary artery bypass patients
Quantification of left ventricular ejection fraction and cardiac output using a novel semi-automated echocardiographic method: a prospective observational study in coronary artery bypass patients Open
View article: The Role of G Protein-Coupled Receptor Kinase 6 Regulation in Inflammation and Pain
The Role of G Protein-Coupled Receptor Kinase 6 Regulation in Inflammation and Pain Open
The G protein-coupled receptor kinase 6 is associated with inflammation and pathological pain. Impairment of GRK6 expression was described in chronic inflammatory diseases such as rheumatoid arthritis and this was shown to be accompanied b…
View article: Hypotension Prediction Index Software to Prevent Intraoperative Hypotension during Major Non-Cardiac Surgery: Protocol for a European Multicenter Prospective Observational Registry (EU-HYPROTECT)
Hypotension Prediction Index Software to Prevent Intraoperative Hypotension during Major Non-Cardiac Surgery: Protocol for a European Multicenter Prospective Observational Registry (EU-HYPROTECT) Open
Background: Intraoperative hypotension is common in patients having non-cardiac surgery and associated with postoperative acute myocardial injury, acute kidney injury, and mortality. Avoiding intraoperative hypotension is a complex task fo…
View article: The impact of the COVID-19 pandemic on non-COVID induced sepsis survival
The impact of the COVID-19 pandemic on non-COVID induced sepsis survival Open
View article: Hemodynamic monitoring with Hypotension Prediction Index versus arterial waveform analysis alone and incidence of perioperative hypotension
Hemodynamic monitoring with Hypotension Prediction Index versus arterial waveform analysis alone and incidence of perioperative hypotension Open
Background Intraoperative hypotension is associated with increased morbidity and mortality. The Hypotension Prediction Index (HPI) is an advancement of the arterial waveform analysis to predict intraoperative hypotension minutes before epi…
View article: Randomisierte kontrollierte multizentrische Studie zur Albuminersatztherapie im septischen Schock (ARISS)
Randomisierte kontrollierte multizentrische Studie zur Albuminersatztherapie im septischen Schock (ARISS) Open
View article: Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site
Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site Open
Background G protein-coupled receptor kinase 6 (GRK6) is part of the G protein-coupled receptor kinase family, whose members act as key regulators of seven-transmembrane receptor signalling. GRK6 seems to play a role in regulation of infla…
View article: Supraglottic airway device versus tracheal intubation and the risk of emergent postoperative intubation after general anaesthesia in adults: a retrospective cohort study
Supraglottic airway device versus tracheal intubation and the risk of emergent postoperative intubation after general anaesthesia in adults: a retrospective cohort study Open
Extracellular vesicles isolated from patients undergoing remote ischemic preconditioning decrease hypoxia-evoked apoptosis of cardiomyoblasts after isoflurane but not propofol exposure Open
View article: True Lumen Stabilization to Overcome Malperfusion in Acute Type I Aortic Dissection
True Lumen Stabilization to Overcome Malperfusion in Acute Type I Aortic Dissection Open
Acute type I aortic dissection (AD) complicated by true lumen (TL) collapse and malperfusion downstream is associated with devastating prognosis. The study reports an institutional mid-term experience with TL stabilization by uncovered ste…
View article: Mitochondrial and Contractile Function of Human Right Atrial Tissue in Response to Remote Ischemic Conditioning
Mitochondrial and Contractile Function of Human Right Atrial Tissue in Response to Remote Ischemic Conditioning Open
Background Remote ischemic preconditioning ( RIPC ) by repeated brief cycles of limb ischemia/reperfusion attenuates myocardial ischemia/reperfusion injury. We aimed to identify a functional parameter reflecting the RIPC ‐induced protectio…
View article: P2284Impact of remote ischemic preconditioning in cardiosurgical patients on contractile and mitochondrial function of right atrial tissue
P2284Impact of remote ischemic preconditioning in cardiosurgical patients on contractile and mitochondrial function of right atrial tissue Open