Ulrich M. Zissler
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View article: Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations
Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations Open
Question Epidemiological studies suggest that respiratory viral infections are major triggers of asthma exacerbations, and clinical studies have suggested the involvement of an increased interleukin‐6 (IL‐6) release. What is the pathophysi…
View article: Acute Effects of Osteopathic Treatment in Long COVID-19 Patients with Fatigue Symptoms: A Randomized, Controlled Trial
Acute Effects of Osteopathic Treatment in Long COVID-19 Patients with Fatigue Symptoms: A Randomized, Controlled Trial Open
Background: Persistent fatigue is among the most commonly reported symptoms in patients suffering from post-acute sequelae of SARS-CoV-2 infection (long COVID). Autonomic dysfunction, measurable via heart rate variability, has been implica…
View article: FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells
FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells Open
Airway epithelia have the challenging task of maintaining functional and structural homeostasis, even when exposed to various stress factors. Transcription factors of the FoxO family can fulfill this complex task, as they act as integratio…
View article: FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells
FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells Open
Airway epithelia have the challenging task of maintaining functional and structural homeostasis, even when exposed to various stress factors. Transcription factors of the FoxO family can fulfill this complex task, as they act as integratio…
View article: Joint Public Review: FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells
Joint Public Review: FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells Open
Airway epithelia have the challenging task of maintaining functional and structural homeostasis, even when exposed to various stress factors. Transcription factors of the FoxO family can fulfill this complex task, as they act as integratio…
View article: Extracellular vesicle <scp>miRNAs</scp> drive aberrant macrophage responses in <scp>NSAID</scp>‐exacerbated respiratory disease
Extracellular vesicle <span>miRNAs</span> drive aberrant macrophage responses in <span>NSAID</span>‐exacerbated respiratory disease Open
Background Extracellular vesicles (EVs) have been implicated in the pathogenesis of asthma, however, how EVs contribute to immune dysfunction and type 2 airway inflammation remains incompletely understood. We aimed to elucidate roles of ai…
View article: FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells
FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells Open
Airway epithelia have the challenging task of maintaining functional and structural homeostasis, even when exposed to various stress factors. Transcription factors of the FoxO family can fulfill this complex task, as they act as integratio…
View article: 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma
17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma Open
Rationale: The strongest genetic risk factor for childhood-onset asthma, the 17q21 locus, is associated with increased viral susceptibility and disease-promoting processes.Objectives: To identify biological targets underlying…
View article: Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort
Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort Open
View article: Genome-Wide Gene Expression Analysis Reveals Unique Genes Signatures of Epithelial Reorganization in Primary Airway Epithelium Induced by Type-I, -II and -III Interferons
Genome-Wide Gene Expression Analysis Reveals Unique Genes Signatures of Epithelial Reorganization in Primary Airway Epithelium Induced by Type-I, -II and -III Interferons Open
Biosensors such as toll-like receptors (TLR) induce the expression of interferons (IFNs) after viral infection that are critical to the first step in cell-intrinsic host defense mechanisms. Their differential influence on epithelial integr…
View article: Role of microRNAs in type 2 diseases and allergen-specific immunotherapy
Role of microRNAs in type 2 diseases and allergen-specific immunotherapy Open
MicroRNAs (miRs) have gained scientific attention due to their importance in the pathophysiology of allergic diseases as well as their potential as biomarkers in allergen-specific treatment options. Their function as post-transcriptional r…
View article: Thermosensitive PLGA–PEG–PLGA Hydrogel as Depot Matrix for Allergen-Specific Immunotherapy
Thermosensitive PLGA–PEG–PLGA Hydrogel as Depot Matrix for Allergen-Specific Immunotherapy Open
Allergen-specific immunotherapy (AIT) is the only currently available curative treatment option for allergic diseases. AIT often includes depot-forming and immunostimulatory adjuvants, to prolong allergen presentation and to improve therap…
View article: Lung Epithelial CYP1 Activity Regulates Aryl Hydrocarbon Receptor Dependent Allergic Airway Inflammation
Lung Epithelial CYP1 Activity Regulates Aryl Hydrocarbon Receptor Dependent Allergic Airway Inflammation Open
The lung epithelial barrier serves as a guardian towards environmental insults and responds to allergen encounter with a cascade of immune reactions that can possibly lead to inflammation. Whether the environmental sensor aryl hydrocarbon …
View article: IgA<sup>+</sup>memory B-cells are significantly increased in patients with asthma and small airway dysfunction
IgA<sup>+</sup>memory B-cells are significantly increased in patients with asthma and small airway dysfunction Open
Background Comprehensive studies investigated the role of T-cells in asthma which led to personalised treatment options targeting severe eosinophilic asthma. However, little is known about the contribution of B-cells to this chronic inflam…
View article: Role of Respiratory Epithelial Cells in Allergic Diseases
Role of Respiratory Epithelial Cells in Allergic Diseases Open
The airway epithelium provides the first line of defense to the surrounding environment. However, dysfunctions of this physical barrier are frequently observed in allergic diseases, which are tightly connected with pro- or anti-inflammator…
View article: Allergen Content of Therapeutic Preparations for Allergen-Specific Immunotherapy of European Paper Wasp Venom Allergy
Allergen Content of Therapeutic Preparations for Allergen-Specific Immunotherapy of European Paper Wasp Venom Allergy Open
Allergy to Polistes dominula (European paper wasp) venom is of particular relevance in Southern Europe, potentially becoming a threat in other regions in the near future, and can be effectively cured by venom immunotherapy (VIT). As allerg…
View article: Bronchial inflammation biomarker patterns link humoral immunodeficiency with bronchiectasis‐related small airway dysfunction
Bronchial inflammation biomarker patterns link humoral immunodeficiency with bronchiectasis‐related small airway dysfunction Open
Background The progression of chronic destructive lung disease in patients with humoral immunodeficiency (ID) and concomitant development of bronchiectasis is difficult to prevent. Lung function tests in these patients typically show bronc…
View article: Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B2 receptor antagonism
Early reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B2 receptor antagonism Open
View article: T2-high asthma phenotypes across lifespan
T2-high asthma phenotypes across lifespan Open
Rationale In adults, personalised asthma treatment targets patients with type 2 (T2)-high and eosinophilic asthma phenotypes. It is unclear whether such classification is achievable in children. Objectives To define T2-high asthma with eas…
View article: Ex Vivo Immunomodulatory Effects of Lactobacillus-, Lacticaseibacillus-, and Bifidobacterium-Containing Synbiotics on Human Peripheral Blood Mononuclear Cells and Monocyte-Derived Dendritic Cells in the Context of Grass Pollen Allergy
Ex Vivo Immunomodulatory Effects of Lactobacillus-, Lacticaseibacillus-, and Bifidobacterium-Containing Synbiotics on Human Peripheral Blood Mononuclear Cells and Monocyte-Derived Dendritic Cells in the Context of Grass Pollen Allergy Open
View article: TGF-β1 Drives Inflammatory Th Cell But Not Treg Cell Compartment Upon Allergen Exposure
TGF-β1 Drives Inflammatory Th Cell But Not Treg Cell Compartment Upon Allergen Exposure Open
TGF-β1 is known to have a pro-inflammatory impact by inducing Th9 and Th17 cells, while it also induces anti-inflammatory Treg cells (Tregs). In the context of allergic airway inflammation (AAI) its dual role can be of critical importance …
View article: Forschung: Allergien und Respirationstrakt – Einfluss der therapeutischen Intervention auf die Atemwege
Forschung: Allergien und Respirationstrakt – Einfluss der therapeutischen Intervention auf die Atemwege Open
View article: Lung epithelial CYP1 activity regulates aryl hydrocarbon receptor dependent allergic airway inflammation
Lung epithelial CYP1 activity regulates aryl hydrocarbon receptor dependent allergic airway inflammation Open
The lung epithelial barrier serves as a guardian towards environmental insults and responds to allergen encounter with a cascade of immune reactions that can possibly lead to inflammation. Whether the environmental sensor aryl hydrocarbon …
View article: Sputum microRNA‐screening reveals Prostaglandin EP3 receptor as selective target in allergen‐specific immunotherapy
Sputum microRNA‐screening reveals Prostaglandin EP3 receptor as selective target in allergen‐specific immunotherapy Open
Background Several microRNAs (miRs) have been described as potential biomarkers in liquid biopsies and in the context of allergic asthma, while therapeutic effects on the airway expression of miRs remain elusive. In this study, we investig…
View article: IL‐37 regulates allergic inflammation by counterbalancing pro‐inflammatory IL‐1 and IL‐33
IL‐37 regulates allergic inflammation by counterbalancing pro‐inflammatory IL‐1 and IL‐33 Open
Background Children with asthma have impaired production of interleukin (IL) 37; in mice, IL‐37 reduces hallmarks of experimental allergic asthma (EAA). However, it remains unclear how IL‐37 exerts its inhibitory properties in asthma. This…
View article: TGF-β1 drives Th9 but not Treg cells upon allergen exposure
TGF-β1 drives Th9 but not Treg cells upon allergen exposure Open
TGF-β1 is known to have a pro-inflammatory impact by inducing Th9 cells, while it also induces anti-inflammatory Treg cells (Tregs). In the context of allergic airway inflammation (AAI) its dual role can be of critical importance in influe…
View article: Early Reduction of SARS-CoV-2 Replication in Bronchial Epithelium by Kinin B<sub>2</sub> Receptor Antagonism
Early Reduction of SARS-CoV-2 Replication in Bronchial Epithelium by Kinin B<sub>2</sub> Receptor Antagonism Open
Background SARS-CoV2 has evolved to enter the host via the ACE2 receptor which is part of the Kinin-kallirein pathway. This complex pathway is only poorly understood in context of immune regulation but critical to control infection. This s…
View article: Secretoglobins in the big picture of immunoregulation in airway diseases
Secretoglobins in the big picture of immunoregulation in airway diseases Open
The proteins of the secretoglobin (SCGB) family are expressed by secretory tissues of barrier organs. They are embedded in immunoregulatory and anti‐inflammatory processes of airway diseases. This review particularly illustrates the immune…
View article: COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy
COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy Open
Background Asthma is a heterogeneous syndrome substantiating the urgent requirement for endotype-specific biomarkers. Dysbalance of fibrosis and fibrolysis in asthmatic lung tissue leads to reduced levels of the inflammation-protective col…
View article: Immunological effects of adjuvanted low‐dose allergoid allergen‐specific immunotherapy in experimental murine house dust mite allergy
Immunological effects of adjuvanted low‐dose allergoid allergen‐specific immunotherapy in experimental murine house dust mite allergy Open
Background Native allergen extracts or chemically modified allergoids are routinely used to induce allergen tolerance in allergen‐specific immunotherapy (AIT), although mechanistic side‐by‐side studies are rare. It is paramount to balance …