Ulrich Thomé
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View article: Complications of thoracoscopic TEF clipping for fistula ligation: a case report of polymer clip migration into the right main bronchus and recurrent fistula
Complications of thoracoscopic TEF clipping for fistula ligation: a case report of polymer clip migration into the right main bronchus and recurrent fistula Open
Introduction Tracheoesophageal fistula (TEF) in neonates with esophageal atresia (EA) is conventionally closed by open or thoracoscopic surgery. We present a case of a rare yet potentially life-threatening complication following thoracosco…
View article: Management of Apnoea in Extremely Preterm Infants: A European Survey
Management of Apnoea in Extremely Preterm Infants: A European Survey Open
Introduction: Episodes of apnoea are common in extremely preterm infants (EPIs) and usually treated with caffeine and respiratory support. Understanding differences in apnoea definitions, monitoring practices, and use of respiratory stimul…
View article: Biomimetic elastin-collagen hybrid hydrogels crosslinked by energetic electrons: towards a tunable in vitro extracellular matrix model of the lung
Biomimetic elastin-collagen hybrid hydrogels crosslinked by energetic electrons: towards a tunable in vitro extracellular matrix model of the lung Open
View article: CPAP caps are associated with restricted head growth and altered skull morphology in newborn infants
CPAP caps are associated with restricted head growth and altered skull morphology in newborn infants Open
Background Continuous positive airway pressure (CPAP) devices for preterm infants are commonly affixed using snug-fitting caps. Monitoring of head growth is standard practice in preterm infants, as stagnant head growth has been associated …
View article: Effects of liberal versus restrictive transfusion strategies on intermittent hypoxaemia in extremely low birthweight infants: secondary analyses of the ETTNO randomised controlled trial
Effects of liberal versus restrictive transfusion strategies on intermittent hypoxaemia in extremely low birthweight infants: secondary analyses of the ETTNO randomised controlled trial Open
Objectives To compare the effect of liberal versus restrictive transfusion strategies on the proportion of time (%time) spent with intermittent hypoxaemia (IH, ie, arterial haemoglobin oxygen saturation measured by pulse oximetry (SpO 2 ) …
View article: Evaluation of a Risk Screening Tool for Retinopathy of Prematurity (ROP) in a German Cohort
Evaluation of a Risk Screening Tool for Retinopathy of Prematurity (ROP) in a German Cohort Open
The DIGIROP-Birth calculator showed good predictive power in our studied population, with an incidence of 3.79% for therapy-requiring ROP. Peri- and postnatal risk factors should be included in ROP screening.
View article: Correction: A recommendation for the use of electrical biosensing technology in neonatology
Correction: A recommendation for the use of electrical biosensing technology in neonatology Open
Correction to: Pediatric Researchhttps://doi.org/10.1038/s41390-024-03369-z, published online 08 July 2024 In the original version of the article, the author’s name Christoph E. Schwarz was incorrectly given as ‘Christop E. Schwarz’. The a…
View article: The association of different types of human milk with bronchopulmonary dysplasia in preterm infants
The association of different types of human milk with bronchopulmonary dysplasia in preterm infants Open
Objective To evaluate the association between different types of human milk feeds and bronchopulmonary dysplasia (BPD) in preterm infants. Methods Data on dispensed mother’s own milk (MOM) and donor human milk (DHM) from Leipzig Milk Bank …
View article: Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants
Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants Open
Importance Retinopathy of prematurity (ROP) is a major morbidity of preterm infants causing visual impairment, including blindness, for which timely treatment is vital and prevention is key. Increasing evidence suggests that exposure to ne…
View article: Indikationen zur Einweisung von Schwangeren in Krankenhäuser der adäquaten Versorgungsstufe (Leitlinienklasse S2k, AWMF-Leitlinien-Register Nr. 087–002)
Indikationen zur Einweisung von Schwangeren in Krankenhäuser der adäquaten Versorgungsstufe (Leitlinienklasse S2k, AWMF-Leitlinien-Register Nr. 087–002) Open
Arbeitsgemeinschaft für Geburtshilfe und Pränatalmedizin in der DGGG (AGG i. d. DGGG)
View article: A recommendation for the use of electrical biosensing technology in neonatology
A recommendation for the use of electrical biosensing technology in neonatology Open
View article: Inhibition of epithelial Na<sup>+</sup>transport: novel mechanism of<i>Ureaplasma</i>-driven lung disease
Inhibition of epithelial Na<sup>+</sup>transport: novel mechanism of<i>Ureaplasma</i>-driven lung disease Open
Background Respiratory tract colonisation with Ureaplasma species has been associated with the development of acute and long-term pulmonary morbidity in preterm infants. Apart from inflammation, the underlying mechanisms of Ureaplasma -dri…
View article: Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome — a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)
Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome — a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III) Open
View article: Incorporating anti-infective drugs into peripherally inserted catheters does not reduce infection rates in neonates
Incorporating anti-infective drugs into peripherally inserted catheters does not reduce infection rates in neonates Open
Purpose This study assesses whether peripherally inserted central venous catheters (PICC), impregnated with anti-infective drugs, reduce the rate of infections in neonates compared with unimpregnated catheters. Methods A retrospective anal…
View article: Video of the Month: Pulsating Umbilicus in a Neonate with Left Ventricular Diverticulum
Video of the Month: Pulsating Umbilicus in a Neonate with Left Ventricular Diverticulum Open
Left ventricular diverticulum (LVD) is a rare malformation presenting in 0.05% of all congenital cardiac anomalies. It is associated with additional cardiac and extracardiac malformations. We report on a female neonate with prenatally diag…
View article: Risk Assessment of Clinical Outcome in the Treatment of Unruptured Intracranial Aneurysms: A Retrospective Analysis of PHASES, ELAPSS, and UIATS Scores in clinical practice
Risk Assessment of Clinical Outcome in the Treatment of Unruptured Intracranial Aneurysms: A Retrospective Analysis of PHASES, ELAPSS, and UIATS Scores in clinical practice Open
View article: A descriptive analysis of human milk dispensed by the Leipzig Donor Human Milk Bank for neonates between 2012 and 2019
A descriptive analysis of human milk dispensed by the Leipzig Donor Human Milk Bank for neonates between 2012 and 2019 Open
Background Human milk banking has become an important aspect of Nutritional medicine. It is not just about the provision of mother’s own milk (MOM) or donor human milk (DHM) in the hospital, but also a strategy to encourage breastfeeding i…
View article: Similar adverse outcome rates with high or low oxygen saturation targets in an area with low background mortality
Similar adverse outcome rates with high or low oxygen saturation targets in an area with low background mortality Open
Background Randomized controlled trials have indicated reduced mortality rates in very preterm infants assigned to high compared to low oxygen saturation (SpO 2 ) target levels, accompanied by higher rates of retinopathy of prematurity and…
View article: Association of response time and intermittent hypoxemia in extremely preterm infants
Association of response time and intermittent hypoxemia in extremely preterm infants Open
Aim To determine the relationship between medical staff's response time (RT) to oxygen saturation (SpO 2 ) below 80% and the associated time from tactile intervention until SpO 2 normalisation (CT). Methods Time‐lapse video and continuous …
View article: Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14+CD16+ Subset upon Toll-like Receptor Stimulation
Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14+CD16+ Subset upon Toll-like Receptor Stimulation Open
Developmentally regulated features of innate immunity are thought to place preterm and term infants at risk of infection and inflammation-related morbidity. Underlying mechanisms are incompletely understood. Differences in monocyte functio…
View article: MUC-FIRE: Study protocol for a randomized multicenter open-label controlled trial to show that MUCous FIstula REfeeding reduces the time from enterostomy closure to full enteral feeds
MUC-FIRE: Study protocol for a randomized multicenter open-label controlled trial to show that MUCous FIstula REfeeding reduces the time from enterostomy closure to full enteral feeds Open
The trial has been registered at clinicaltrials.gov (number: NCT03469609, date of registration: March 19, 2018; last update: January 20, 2023, https://clinicaltrials.gov/ct2/show/NCT03469609?term=NCT03469609&draw=2&rank=1).
View article: Incidence of Intermittent Hypoxemia Increases during Clinical Care and Parental Touch in Extremely Preterm Infants
Incidence of Intermittent Hypoxemia Increases during Clinical Care and Parental Touch in Extremely Preterm Infants Open
Objectives: An increased frequency of intermittent hypoxemia (IH) is associated with a higher risk for poor developmental outcomes, disability, or death in extremely preterm infants. The objective of the prFesent study is to quantify the e…
View article: Changes in CSF Surface Tension in Relation to Surfactant Proteins in Children with Intraventricular Hemorrhage
Changes in CSF Surface Tension in Relation to Surfactant Proteins in Children with Intraventricular Hemorrhage Open
The regulation of surface tension (ST) by surfactants plays an important role in the human respiratory system but is largely unexplored in brain homeostasis. The aim of this study was to evaluate changes in ST in relation to surfactant pro…
View article: The Value of Perinatal Factors, Blood Biomarkers and Microbiological Colonization Screening in Predicting Neonatal Sepsis
The Value of Perinatal Factors, Blood Biomarkers and Microbiological Colonization Screening in Predicting Neonatal Sepsis Open
Background: Neonatal sepsis is one of the most important causes of elevated morbidity and mortality rates in neonatal intensive care units worldwide. While the clinical manifestations of neonatal sepsis tend to be nonspecific, its rapid de…
View article: Automated Complete Blood Cell Count Using Sysmex XN-9000® in the Diagnosis of Newborn Infection
Automated Complete Blood Cell Count Using Sysmex XN-9000® in the Diagnosis of Newborn Infection Open
The early identification of septically infected newborn infants is important for ensuring good outcomes. Blood cell differentiations are helpful, but they are often time consuming and inaccurate. In this study, we evaluated the use of auto…
View article: Mechanical properties of the premature lung: From tissue deformation under load to mechanosensitivity of alveolar cells
Mechanical properties of the premature lung: From tissue deformation under load to mechanosensitivity of alveolar cells Open
Many preterm infants require mechanical ventilation as life-saving therapy. However, ventilation-induced overpressure can result in lung diseases. Considering the lung as a viscoelastic material, positive pressure inside the lung results i…
View article: Growth Patterns of Children With Short Stature in Adulthood According to Auxological Status and Maturity at Birth
Growth Patterns of Children With Short Stature in Adulthood According to Auxological Status and Maturity at Birth Open
Context Prematurity carries a risk for impaired postnatal growth and long-term growth restriction. Especially children born SGA seem vulnerable for poor growth, as a persistent short stature can be observed in app 10-15% of these children.…
View article: “Alcohol intoxication by proxy on a NICU” - a case report
“Alcohol intoxication by proxy on a NICU” - a case report Open
View article: Association of Administration of Surfactant Using Less Invasive Methods With Outcomes in Extremely Preterm Infants Less Than 27 Weeks of Gestation
Association of Administration of Surfactant Using Less Invasive Methods With Outcomes in Extremely Preterm Infants Less Than 27 Weeks of Gestation Open
Importance The inclusion of less invasive surfactant administration (LISA) in the care of preterm infants has been found to be beneficial for respiratory outcomes. Recently, the OPTIMIST trial found higher mortality rates in the subgroup o…
View article: Albumin Stimulates Epithelial Na+ Transport and Barrier Integrity by Activating the PI3K/AKT/SGK1 Pathway
Albumin Stimulates Epithelial Na+ Transport and Barrier Integrity by Activating the PI3K/AKT/SGK1 Pathway Open
Albumin is a major serum protein and is frequently used as a cell culture supplement. It is crucially involved in the regulation of osmotic pressure and distribution of fluid between different compartments. Alveolar epithelial Na+ transpor…