Ulrike Klemm
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View article: Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics
Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics Open
The multimeric plasma glycoprotein (GP) von Willebrand factor (VWF) is best known for recruiting platelets to sites of injury during primary hemostasis. Generally, mutations in the VWF gene lead to loss of hemostatic activity and thus the …
View article: Inositol hexakisphosphate increases the size of platelet aggregates
Inositol hexakisphosphate increases the size of platelet aggregates Open
View article: The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction
The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction Open
The frequent von Willebrand factor (VWF) variant p.Phe2561Tyr is located within the C4 domain, which also harbors the platelet GPIIb/IIIa-binding RGD sequence. To investigate its potential effect on hemostasis, we genotyped 865 patients wi…