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View article: E3 ubiquitin ligase SKP2 limits autophagy during <i>S. aureus</i> infection
E3 ubiquitin ligase SKP2 limits autophagy during <i>S. aureus</i> infection Open
Ubiquitination is a posttranslational modification that affects protein function, stability, and localization and is thereby balancing protein homeostasis. During infection, ubiquitination is crucial in regulating host cell signaling pathw…
View article: Deletion of the E3 ubiquitin ligase LRSAM1 fosters intracellular Staphylococcus aureus survival
Deletion of the E3 ubiquitin ligase LRSAM1 fosters intracellular Staphylococcus aureus survival Open
Background Intracellular invasion and persistence of Staphylococcus aureus can lead to chronic infection and is an effective strategy for the pathogen to evade the host immune response and antibiotic therapy. Selective ubiquitination of ba…
View article: Response to the comment on the article “No detrimental effect on the hand microbiome of health care staff by frequent alcohol-based antisepsis”
Response to the comment on the article “No detrimental effect on the hand microbiome of health care staff by frequent alcohol-based antisepsis” Open
View article: Virulent African swine fever virus infection of porcine monocytes causes SLA I subversion due to loss of proper ER structure/function
Virulent African swine fever virus infection of porcine monocytes causes SLA I subversion due to loss of proper ER structure/function Open
African swine fever virus (ASFV) is a large DNA virus of the Asfarviridae family that causes a fatal hemorrhagic disease in domestic swine and wild boar. Infections with moderately virulent strains predominantly result in a milder clinical…
View article: Staphylococcal SplA and SplB serine proteases target ubiquitin(-like) specific proteases
Staphylococcal SplA and SplB serine proteases target ubiquitin(-like) specific proteases Open
Staphylococcus aureus is a Gram-positive opportunistic pathogen that has colonized nearly 30% of the human population and can cause life-threatening infections. S. aureus exports a variety of virulence factors, such as a novel set of extra…
View article: No detrimental effect on the hand microbiome of health care staff by frequent alcohol-based antisepsis
No detrimental effect on the hand microbiome of health care staff by frequent alcohol-based antisepsis Open
Frequent occupational use of EBHR did not adversely affect the composition of the human hand microbiome. Thus, daily hand antisepsis retains its significance as the most important procedure for infection control.
View article: How long do bacteria, fungi, protozoa, and viruses retain their replication capacity on inanimate surfaces? A systematic review examining environmental resilience versus healthcare-associated infection risk by “fomite-borne risk assessment”
How long do bacteria, fungi, protozoa, and viruses retain their replication capacity on inanimate surfaces? A systematic review examining environmental resilience versus healthcare-associated infection risk by “fomite-borne risk assessment” Open
SUMMARY In healthcare settings, contaminated surfaces play an important role in the transmission of nosocomial pathogens potentially resulting in healthcare-associated infections (HAI). Pathogens can be transmitted directly from frequent h…
View article: DiscovEpi: automated whole proteome MHC-I-epitope prediction and visualization
DiscovEpi: automated whole proteome MHC-I-epitope prediction and visualization Open
View article: Predicting the next pandemic: VACCELERATE ranking of the World Health Organization's Blueprint for Action to Prevent Epidemics
Predicting the next pandemic: VACCELERATE ranking of the World Health Organization's Blueprint for Action to Prevent Epidemics Open
View article: Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia Open
Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A -rearranged ( KMT2A-r ) acute myeloid leukemia (AML) but resistance frequently develops to single agents. This points to a need for …
View article: Proteasome inhibition potentiates Kv1.3 potassium channel expression as therapeutic target in drug-sensitive and -resistant human melanoma cells
Proteasome inhibition potentiates Kv1.3 potassium channel expression as therapeutic target in drug-sensitive and -resistant human melanoma cells Open
Primary and acquired therapy resistance is a major problem in patients with BRAF-mutant melanomas being treated with BRAF and MEK inhibitors (BRAFI, MEKi). Therefore, development of alternative therapy regimes is still required. In this re…
View article: Supplemental Figures S1-S7 from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice
Supplemental Figures S1-S7 from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice Open
File contains supplementary figures showing TAP-specific peptide translocation, growth of WT and Erap1-/- HCC in different recipients, gating strategy for T cell analysis, antigen-dependent T cell expansion, rejection of WT and Erap1-/- HC…
View article: Supplemental Methods from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice
Supplemental Methods from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice Open
File contains supplementary methods describing HPLC analysis, peptide translocation assay, histological staining, western blot analysis, flow cytometry, retroviral transductions, CTL assays, and in vivo cytotoxicity assays.
View article: Supplemental Methods from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice
Supplemental Methods from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice Open
File contains supplementary methods describing HPLC analysis, peptide translocation assay, histological staining, western blot analysis, flow cytometry, retroviral transductions, CTL assays, and in vivo cytotoxicity assays.
View article: Supplemental Table S1 from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice
Supplemental Table S1 from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice Open
Numerical summary of tumor rejection experiments
View article: Data from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice
Data from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice Open
Cytotoxic T lymphocytes can reject established tumors if their target peptide is efficiently presented by MHC class I molecules (pMHC-I) on the surface of cancerous cells. Therapeutic success upon adoptive T-cell transfer (ATT), however, r…
View article: Supplemental Table S1 from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice
Supplemental Table S1 from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice Open
Numerical summary of tumor rejection experiments
View article: Data from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice
Data from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice Open
Cytotoxic T lymphocytes can reject established tumors if their target peptide is efficiently presented by MHC class I molecules (pMHC-I) on the surface of cancerous cells. Therapeutic success upon adoptive T-cell transfer (ATT), however, r…
View article: Supplemental Figures S1-S7 from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice
Supplemental Figures S1-S7 from ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice Open
File contains supplementary figures showing TAP-specific peptide translocation, growth of WT and Erap1-/- HCC in different recipients, gating strategy for T cell analysis, antigen-dependent T cell expansion, rejection of WT and Erap1-/- HC…
View article: Supplementary Methods and Figure Legends from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
Supplementary Methods and Figure Legends from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells Open
Supplementary Methods and Figure Legends from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
View article: Supplementary Figure 1 from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
Supplementary Figure 1 from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells Open
Supplementary Figure 1 from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
View article: Supplementary Figure 2 from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
Supplementary Figure 2 from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells Open
Supplementary Figure 2 from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
View article: Data from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
Data from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells Open
Resistance of tumor cells to cisplatin is a common feature frequently encountered during chemotherapy against melanoma caused by various known and unknown mechanisms. To overcome drug resistance toward cisplatin, a targeted treatment using…
View article: Supplementary Figure 2 from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
Supplementary Figure 2 from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells Open
Supplementary Figure 2 from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
View article: Supplementary Methods and Figure Legends from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
Supplementary Methods and Figure Legends from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells Open
Supplementary Methods and Figure Legends from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
View article: Data from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
Data from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells Open
Resistance of tumor cells to cisplatin is a common feature frequently encountered during chemotherapy against melanoma caused by various known and unknown mechanisms. To overcome drug resistance toward cisplatin, a targeted treatment using…
View article: Supplementary Figure 1 from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
Supplementary Figure 1 from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells Open
Supplementary Figure 1 from Combined Effect of Proteasome and Calpain Inhibition on Cisplatin-Resistant Human Melanoma Cells
View article: T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation
T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation Open
Upon antigen recognition by the T cell receptor (TCR), a complex signaling network orchestrated by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs) regulates the transmission of the extracellular signal to the nucle…
View article: The epidemiological relevance of the COVID-19-vaccinated population is decreasing after booster vaccination, as shown by incidence rate ratios
The epidemiological relevance of the COVID-19-vaccinated population is decreasing after booster vaccination, as shown by incidence rate ratios Open
View article: Recycling and Reshaping—E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response
Recycling and Reshaping—E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response Open
T cell activation plays a central role in supporting and shaping the immune response. The induction of a functional adaptive immune response requires the control of signaling processes downstream of the T cell receptor (TCR). In this regar…