Uma Maheswari Deshetty
YOU?
Author Swipe
View article: Protective Effects of N-Acetylcysteine in Alleviating Cocaine-Mediated Microglial Activation and Neuroinflammation
Protective Effects of N-Acetylcysteine in Alleviating Cocaine-Mediated Microglial Activation and Neuroinflammation Open
Cocaine misuse induces microglial activation and neuroinflammation, contributing to neurodegeneration and behavioral impairments. Prior studies have shown that cocaine induces mitochondrial dysfunction, dysregulated mitophagy, and lysosoma…
View article: Methamphetamine-mediated astrocytic pyroptosis and neuroinflammation involves miR-152–NLRP6 inflammasome signaling axis
Methamphetamine-mediated astrocytic pyroptosis and neuroinflammation involves miR-152–NLRP6 inflammasome signaling axis Open
View article: Single-Cell RNA-Seq Uncovers Robust Glial Cell Transcriptional Changes in Methamphetamine-Administered Mice
Single-Cell RNA-Seq Uncovers Robust Glial Cell Transcriptional Changes in Methamphetamine-Administered Mice Open
Methamphetamine is a highly addictive stimulant known to cause neurotoxicity, cognitive deficits, and immune dysregulation in the brain. Despite significant research, the molecular mechanisms driving methamphetamine-induced neurotoxicity a…
View article: HIV-1 Tat-Mediated Human Müller Glial Cell Senescence Involves Endoplasmic Reticulum Stress and Dysregulated Autophagy
HIV-1 Tat-Mediated Human Müller Glial Cell Senescence Involves Endoplasmic Reticulum Stress and Dysregulated Autophagy Open
Antiretroviral treatments have notably extended the lives of individuals with HIV and reduced the occurrence of comorbidities, including ocular manifestations. The involvement of endoplasmic reticulum (ER) stress in HIV-1 pathogenesis rais…
View article: Non-Coding RNAs in HIV Infection, NeuroHIV, and Related Comorbidities
Non-Coding RNAs in HIV Infection, NeuroHIV, and Related Comorbidities Open
NeuroHIV affects approximately 30–60% of people living with HIV-1 (PLWH) and is characterized by varying degrees of cognitive impairments, presenting a multifaceted challenge, the underlying cause of which is chronic, low-level neuroinflam…
View article: Gene therapy for the heart: encapsulated viruses to the rescue
Gene therapy for the heart: encapsulated viruses to the rescue Open
This commentary provides an in-depth analysis and perspective on the pioneering research article titled ‘Extracellular Vesicle-Encapsulated Adeno-Associated Viruses for Therapeutic Gene Delivery to the Heart’. The original study explores t…
View article: Opioid abuse and SIV infection in non-human primates
Opioid abuse and SIV infection in non-human primates Open
View article: Potential Biomarkers in Experimental Animal Models for Traumatic Brain Injury
Potential Biomarkers in Experimental Animal Models for Traumatic Brain Injury Open
Traumatic brain injury (TBI) is a complex and multifaceted disorder that has become a significant public health concern worldwide due to its contribution to mortality and morbidity. This condition encompasses a spectrum of injuries, includ…