Muhammad Imran Naseer
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View article: Synthesis and Characterization of Titanium Oxide Nanomaterials for Potential Photocatalytic Applications
Synthesis and Characterization of Titanium Oxide Nanomaterials for Potential Photocatalytic Applications Open
Titanium dioxide (TiO₂) has emerged as one of the most promising semiconductor materials because of its remarkable photocatalytic activities, chemical stability, and environmental compatibility. This study presents a comprehensive investig…
View article: Frequency of Pre-Analytical Errors and Its Causes in Glucose Specimen Collection: A Cross-Sectional Analysis in Bahawal Victoria Hospital, Pakistan
Frequency of Pre-Analytical Errors and Its Causes in Glucose Specimen Collection: A Cross-Sectional Analysis in Bahawal Victoria Hospital, Pakistan Open
Background: The laboratory testing process comprises the pre-analytical, analytical, and post-analytical phases. The pre-analytical phase has the highest frequency of error among these three stages. The purpose of the study was to determin…
View article: Prevalence and Clinical Implications of <i>BRCA1</i> and <i>BRCA2 </i>Mutations in Breast and Ovarian Cancer Among Pakistani Women
Prevalence and Clinical Implications of <i>BRCA1</i> and <i>BRCA2 </i>Mutations in Breast and Ovarian Cancer Among Pakistani Women Open
Background: Major causes of hereditary breast and ovarian cancers are mutations in the BRCA1 and BRCA2 genes, especially affecting cancer type, onset, and prognosis. Objective: To investigate the frequency and clinical correlations of BRCA…
View article: A narrative review of research advancements in pharmacogenetics of cardiovascular disease and impact on clinical implications
A narrative review of research advancements in pharmacogenetics of cardiovascular disease and impact on clinical implications Open
Pharmacogenetics can enhance cardiovascular disease (CVD) treatment by tailoring drug therapy to genetic profiles and minimising trial-and-error approaches. Genetic variability influences responses to common CVD drugs, including antiplatel…
View article: Measuring Health-related Quality of Life in Pediatric Patients with Ultra-rare Diseases: A Multicenter Study
Measuring Health-related Quality of Life in Pediatric Patients with Ultra-rare Diseases: A Multicenter Study Open
Background: Ultra-rare diseases (URDs) are defined based on point prevalence and are classified as conditions affecting fewer than 1 in 50,000 individuals, and they are more likely to exist among communities with higher consanguinity rates…
View article: Mitigating soil erosion in arid landscapes: Integrating RUSLE and geospatial analysis for sustainable land management
Mitigating soil erosion in arid landscapes: Integrating RUSLE and geospatial analysis for sustainable land management Open
Soil erosion, induced by water, wind, and human factors, poses a significant threat to sustainable land management and agricultural productivity. Land degradation, sudden meteorological changes, and the intensive use of unsustainable pract…
View article: PCR-Based Analysis of HBV and HCV Viral Loads and Their Impact on Liver Disease in Chronic Patients
PCR-Based Analysis of HBV and HCV Viral Loads and Their Impact on Liver Disease in Chronic Patients Open
Background: Chronic hepatitis B (HBV) and C (HCV) infections are leading causes of global liver disease morbidity and mortality, yet the precise relationship between viral load and liver disease severity in regional populations remains ins…
View article: Management of Hepatitis C Virus and Hepatitis B Virus Infection in the Setting of Kidney Disease
Management of Hepatitis C Virus and Hepatitis B Virus Infection in the Setting of Kidney Disease Open
Background: Chronic kidney disease (CKD) increases susceptibility to hepatitis B and C infections, both of which complicate renal management and elevate morbidity, particularly in populations with frequent healthcare exposures. There is li…
View article: Liver Disease–Associated Glomerulopathies: Clinical Spectrum, Pathophysiology, and Implications for Renal Prognosis
Liver Disease–Associated Glomerulopathies: Clinical Spectrum, Pathophysiology, and Implications for Renal Prognosis Open
Background: Liver disease–associated glomerulopathies (LDAGs) represent a clinically significant but often underrecognized cause of renal dysfunction in patients with chronic liver disease, particularly in regions with a high prevalence of…
View article: Update on Assessment of Estimated Glomerular Filtration Rate in Patients with Cirrhosis
Update on Assessment of Estimated Glomerular Filtration Rate in Patients with Cirrhosis Open
Background: cirrhosis causes muscle loss and changes in creatinine levels, it is difficult to assess renal function in these patients. Often, creatinine-based processes calculate GFR too high which causes renal diseases to be diagnosed lat…
View article: Exploring Acid-Base Imbalance in Liver Cirrhosis: Diagnostic and Therapeutic Perspectives
Exploring Acid-Base Imbalance in Liver Cirrhosis: Diagnostic and Therapeutic Perspectives Open
Background: liver cirrhosis Patients experience disturbances in their body acid-base balance which reflects disease of the liver and affect the whole body. Possible imbalances can be either metabolic alkalosis, respiratory alkalosis or hig…
View article: COMPARATIVE EFFECTIVENESS OF ELISA, PCR, AND NGS FOR EMERGING INFECTIOUS DISEASES
COMPARATIVE EFFECTIVENESS OF ELISA, PCR, AND NGS FOR EMERGING INFECTIOUS DISEASES Open
Background: Emerging infectious diseases require rapid and accurate diagnostic tools to guide clinical decision-making and public health interventions. Traditional and molecular diagnostic methods such as ELISA, PCR, and Next-Generation Se…
View article: EXPERIENCES OF PUBLIC HEALTH WORKERS IN MANAGING THE COVID-19 PANDEMIC: A QUALITATIVE STUDY
EXPERIENCES OF PUBLIC HEALTH WORKERS IN MANAGING THE COVID-19 PANDEMIC: A QUALITATIVE STUDY Open
Background: The COVID-19 pandemic posed unprecedented challenges for public health systems globally, thrusting public health workers (PHWs) into the frontline of outbreak management, often under intense physical, emotional, and ethical str…
View article: SOCIOECONOMIC, ENVIRONMENTAL, AND BEHAVIORAL RISK FACTORS ASSOCIATED WITH CUTANEOUS LEISHMANIASIS: A MULTI-REGION STUDY
SOCIOECONOMIC, ENVIRONMENTAL, AND BEHAVIORAL RISK FACTORS ASSOCIATED WITH CUTANEOUS LEISHMANIASIS: A MULTI-REGION STUDY Open
Background: Cutaneous leishmaniasis (CL) remains a major public health concern in endemic regions, with socioeconomic, environmental, and behavioral factors playing a crucial role in disease transmission and severity. Understanding these d…
View article: Evaluation of potential substrates and inhibitors of MRP2 transporter to predict effective combinatorial chemotherapeutic agents for treating MRP2-associated non-responsive colorectal cancer
Evaluation of potential substrates and inhibitors of MRP2 transporter to predict effective combinatorial chemotherapeutic agents for treating MRP2-associated non-responsive colorectal cancer Open
Colorectal cancer (CRC) is a significant cause of death globally, due to the emergence of multidrug resistance (MDR), which limits the effectiveness of conventional chemotherapy. Multidrug resistance-associated protein 2 (MRP2) plays a cri…
View article: Emerging biomarkers in major depressive disorder: Diagnostic, prognostic, and therapeutic implications
Emerging biomarkers in major depressive disorder: Diagnostic, prognostic, and therapeutic implications Open
Recent advancements in biomarker research for the diagnosis, prognosis, and treatment strategies of major depressive disorder (MDD) have yielded significant findings that warrant documentation. The clinical demand for biomarkers persists d…
View article: Effect of novel IL-8 gene mutation on its protein structure and stability among ovarian cancer patients in Saudi Arabia
Effect of novel IL-8 gene mutation on its protein structure and stability among ovarian cancer patients in Saudi Arabia Open
Despite advancements in therapeutics, early diagnosis of ovarian cancer (OC) remains a challenge due to its asymptomatic progression and it is often diagnosed at an advanced stage. Interleukin-8 (IL-8), a pro-inflammatory chemokine with an…
View article: Acute and chronic impact of interleukin-33 stimulation on chemokines and growth factors in human cord blood-derived mast cells
Acute and chronic impact of interleukin-33 stimulation on chemokines and growth factors in human cord blood-derived mast cells Open
Background Mast cells (MCs) are multifaceted immune cells that are capable of recognizing and responding to various stimuli by releasing an array of cytokines. We aimed to use human cord blood-derived mast cells (hCBMCs) as a model to eval…
View article: Clinical whole Exome Sequencing Reveals Novel Homozygous Missense Variant in the PMPCA Gene causing Autosomal Recessive Spinocerebellar Ataxia
Clinical whole Exome Sequencing Reveals Novel Homozygous Missense Variant in the PMPCA Gene causing Autosomal Recessive Spinocerebellar Ataxia Open
Background & Objective: Autosomal recessive cerebellar ataxias (ARCA) are rare heterogenous neurodegenerative disorders characterized by degeneration of the cerebellum and spinal cord with an early onset before the age of 20 years. PMPCA (…
View article: Short-term effectiveness and side effects of ketogenic diet for drug-resistant epilepsy in children with genetic epilepsy syndromes
Short-term effectiveness and side effects of ketogenic diet for drug-resistant epilepsy in children with genetic epilepsy syndromes Open
Background Drug-resistant epilepsy (DRE) impacts a significant portion, one-third, of individuals diagnosed with epilepsy. In such cases, exploring non-pharmacological interventions are crucial, with the ketogenic diet (KD) standing out as…
View article: Acute and prolonged effects of interleukin-33 on cytokines in human cord blood-derived mast cells
Acute and prolonged effects of interleukin-33 on cytokines in human cord blood-derived mast cells Open
Mast cells are multifaceted cells localized in tissues and possess various surface receptors that allow them to respond to inner and external threat signals. Interleukin-33 (IL-33) is a cytokine released by structural cells in response to …
View article: Current genetic models for studying congenital heart diseases: Advantages and disadvantages
Current genetic models for studying congenital heart diseases: Advantages and disadvantages Open
Congenital heart disease (CHD) encompasses a diverse range of structural and functional anomalies that affect the heart and the major blood vessels. Epidemiological studies have documented a global increase in CHD prevalence, which can be …
View article: Characteristics of Cu-Au-Bearing Quartz Veins at Danyore Valley Area, Kohistan Terrane, Northern Pakistan: Evidence from Geological, Geochemical, and Geochronological Studies
Characteristics of Cu-Au-Bearing Quartz Veins at Danyore Valley Area, Kohistan Terrane, Northern Pakistan: Evidence from Geological, Geochemical, and Geochronological Studies Open
Danyore Valley area is a new prospect of copper-gold mineralization in the Gilgit-Baltistan province, Kohistan terrane, northern Pakistan. The mineralization is Cu-Au vein-type, localized within quartz veins and controlled by a fracture sy…
View article: Whole exome sequencing of a novel homozygous missense variant in <i>PALB2</i> gene leading to Fanconi anaemia complementation group
Whole exome sequencing of a novel homozygous missense variant in <i>PALB2</i> gene leading to Fanconi anaemia complementation group Open
Partner and localiser of BRCA2 (PALB2), also known as FANCN, is a key tumour suppressor gene in maintaining genome integrity. Monoallelic mutations of PALB2 are associated with breast and overian cancers, while bi-allelic mutations cause F…