Safia K. Ahmed
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View article: Case Report: Should IGF-1R targeted therapy be revisited in Ewing sarcoma? a report of long-term complete response and review of the literature
Case Report: Should IGF-1R targeted therapy be revisited in Ewing sarcoma? a report of long-term complete response and review of the literature Open
Introduction Ewing sarcoma (ES) is a malignancy that mostly affects adolescents and young adults, with relapse or refractory cases posing major therapeutic challenges. Its unique transcriptional profile offers multiple targetable pathways,…
View article: Proton Beam Therapy and the AYA Sarcoma Patient Journey: Highlighting Needs from Diagnosis to Survivorship
Proton Beam Therapy and the AYA Sarcoma Patient Journey: Highlighting Needs from Diagnosis to Survivorship Open
Background: Adolescents and young adults (15–39 years of age at time of diagnosis: AYA) with sarcoma are a unique patient population. The objective of this review is to examine the literature outlining the benefits of proton beam therapy (…
View article: Immediate 2-Stage breast reconstruction outcomes after proton or photon postmastectomy radiotherapy
Immediate 2-Stage breast reconstruction outcomes after proton or photon postmastectomy radiotherapy Open
Although approximately one-fifth of women experienced SSI or unplanned reoperation, the rate of reconstruction failure was low (7.6%) and most women achieved a successful reconstruction outcome with PMRT using photons or protons. The lower…
View article: Simulation‐free workflow for lattice radiation therapy using deep learning predicted synthetic computed tomography: A feasibility study
Simulation‐free workflow for lattice radiation therapy using deep learning predicted synthetic computed tomography: A feasibility study Open
Purpose Lattice radiation therapy (LRT) is a form of spatially fractionated radiation therapy that allows increased total dose delivery aiming for improved treatment response without an increase in toxicities, commonly utilized for palliat…
View article: Definitive Radiation Therapy for Ewing Sarcoma: Outcomes Based on Tumor Volume, Dose, and Fractionation
Definitive Radiation Therapy for Ewing Sarcoma: Outcomes Based on Tumor Volume, Dose, and Fractionation Open
DE-RT was associated with a trend toward better LF in all tumors without toxicity or plan quality changes. Ultralarge tumors demonstrated poor LF rates and necessitate further study.
View article: Radiographic and pathologic response of myxoid liposarcoma treated with preoperative radiotherapy
Radiographic and pathologic response of myxoid liposarcoma treated with preoperative radiotherapy Open
Background We retrospectively assessed volumetric response of myxoid liposarcoma (MLPS) with preoperative radiotherapy (RT) and sought to identify disease and treatment characteristics associated with response. Patients and methods We iden…
View article: Preoperative Radiotherapy in Patients With Localized Ewing Sarcoma Enrolled on AEWS1031: A Report From the Children's Oncology Group
Preoperative Radiotherapy in Patients With Localized Ewing Sarcoma Enrolled on AEWS1031: A Report From the Children's Oncology Group Open
Patients with resectable Ewing sarcoma (ES) in select sites, such as the pelvis or chest wall, have a higher risk of positive microscopic margins following surgery. AEWS1031 was the first North American/Australasia ES cooperative group tri…
View article: NF1 with Ewing’s Sarcoma and Thoracopulmonary PNET with Gastrointestinal Neoplasm: A Case Report of Synchronous Malignancies
NF1 with Ewing’s Sarcoma and Thoracopulmonary PNET with Gastrointestinal Neoplasm: A Case Report of Synchronous Malignancies Open
Synchronous malignancies are rare and pose significant diagnostic and therapeutic challenges due to their complex presentations and diverse aetiologies. This report highlights two unique cases emphasising the importance of a multidisciplin…
View article: Pulmonary Toxicities in Pediatric Patients Treated With Total Body Irradiation Using the Lateral Opposed Fields Technique
Pulmonary Toxicities in Pediatric Patients Treated With Total Body Irradiation Using the Lateral Opposed Fields Technique Open
Purpose Pulmonary toxicity (PT) remains a concern following total body irradiation (TBI). This study describes the incidence and factors associated with PT in a cohort of patients homogeneously treated with the lateral opposed fields techn…
View article: Optimizing Ewing Sarcoma and Osteosarcoma Biopsy Acquisition: A Children’s Oncology Group Bone Tumor Committee Consensus Statement
Optimizing Ewing Sarcoma and Osteosarcoma Biopsy Acquisition: A Children’s Oncology Group Bone Tumor Committee Consensus Statement Open
Trends in diagnostic biopsy sample collection approaches for primary bone sarcomas have shifted in the past 2 decades. Although open/incisional biopsies used to be the predominant approach to obtain diagnostic material for Ewing sarcoma an…
View article: Data from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast
Data from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast Open
Purpose: To evaluate the impact of trimodality treatment versus mono- or dual-therapy for radiation-associated angiosarcoma of the breast (RAASB) after prior breast cancer treatment. Experimental Design: With IRB approval, we identified pa…
View article: Supplemental Figure 2 from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast
Supplemental Figure 2 from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast Open
Supplemental Figure 2. Kaplan Meier survival curve of local recurrence free survival (LRFS).
View article: Supplemental Figure 2 from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast
Supplemental Figure 2 from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast Open
Supplemental Figure 2. Kaplan Meier survival curve of local recurrence free survival (LRFS).
View article: Supplemental Figure 1 from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast
Supplemental Figure 1 from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast Open
Supplemental Figure 1. Clinical response in one representative patient treated with trimodality therapy who experienced a pathologic complete response to preoperative chemoradiation; a) baseline photograph at time of diagnosis/ Pre-treatme…
View article: Supplemental Figure 1 from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast
Supplemental Figure 1 from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast Open
Supplemental Figure 1. Clinical response in one representative patient treated with trimodality therapy who experienced a pathologic complete response to preoperative chemoradiation; a) baseline photograph at time of diagnosis/ Pre-treatme…
View article: Supplemental Figure 3 from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast
Supplemental Figure 3 from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast Open
Supplemental Figure 3. Kaplan Meier survival curve of distant recurrence free survival (DRFS).
View article: Supplemental Figure 3 from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast
Supplemental Figure 3 from Trimodality Therapy Improves Disease Control in Radiation-Associated Angiosarcoma of the Breast Open
Supplemental Figure 3. Kaplan Meier survival curve of distant recurrence free survival (DRFS).
View article: GCT-26. INTRACRANIAL NON-GERMINOMATOUS GERM CELL TUMOR WITH MALIGNANT TRANSFORMATION TO EMBRYONAL RHABDOMYSARCOMA
GCT-26. INTRACRANIAL NON-GERMINOMATOUS GERM CELL TUMOR WITH MALIGNANT TRANSFORMATION TO EMBRYONAL RHABDOMYSARCOMA Open
BACKGROUND Non-germinomatous germ cell tumors (NGGCT) constitute 35%- 45% of intracranial germ cell tumors. Growing teratoma syndrome has been observed in patients with NGGCTs after starting chemotherapy. While growing teratomas are typica…
View article: Myxofibrosarcoma: Outcomes, Prognostic Factors, and Role of Neoadjuvant Radiation Therapy
Myxofibrosarcoma: Outcomes, Prognostic Factors, and Role of Neoadjuvant Radiation Therapy Open
Despite the infiltrative nature of MFS, preoperative RT followed by definitive surgical excision, especially in the setting of a reliable frozen section margin analysis, was associated with excellent local control.
View article: 116P Role of extracorporeal irradiation in primary malignant bone tumors
116P Role of extracorporeal irradiation in primary malignant bone tumors Open
The standard management approach for malignant bone tumours (MBT) is multidisciplinary, especially when there is a concern for limb salvage. In extracorporeal irradiation (ECI), the tumour-bearing segment of bone is excised en bloc; the tu…
View article: NSAID-induced Gastric Ulcer Disease: A Deleterious Connection
NSAID-induced Gastric Ulcer Disease: A Deleterious Connection Open
Gastric ulcers induced by non-steroidal anti-inflammatory drug (NSAID) usage have become a common public health problem, and several studies have established chronic NSAID usage to be one of the risk factors for the pathogenesis of peptic …
View article: Spatially Fractionated Radiation Therapy in Sarcomas: A Large Single-Institution Experience
Spatially Fractionated Radiation Therapy in Sarcomas: A Large Single-Institution Experience Open
The current series is the largest to date documenting outcomes for SFRT in sarcomas. Our results suggest combined SFRT with EBRT is associated with a favorable toxicity profile and high rates of symptomatic and radiographic responses for m…
View article: Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas
Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas Open
Skull-base chordoma and chondrosarcoma are rare radioresistant tumors treated with surgical resection and/or radiotherapy. Because of the established dosimetric and biological benefits of heavy particle therapy, we performed a systematic a…
View article: 144P Correlation of EZH2 expression and response to chemoradiotherapy in patients with locally advanced inoperable oral cavity and oropharyngeal squamous cell cancers
144P Correlation of EZH2 expression and response to chemoradiotherapy in patients with locally advanced inoperable oral cavity and oropharyngeal squamous cell cancers Open
Head and neck cancer (HNC) is a major global health concern. Despite advances in treatment, the outcome is poor due to locoregional failure. Therefore, there is an urgent need to identify molecular markers that can predict recurrence and t…
View article: Dose delivery reproducibility for PBS proton treatment of breast cancer patients with and without mask immobilization
Dose delivery reproducibility for PBS proton treatment of breast cancer patients with and without mask immobilization Open
Background Setup reproducibility of the tissue in the proton beam path is critical in maintaining the planned clinical target volume (CTV) dose coverage and sparing the organs at risk (OAR). In this study, we retrospectively evaluated radi…
View article: Proton Therapy in the Adolescent and Young Adult Population
Proton Therapy in the Adolescent and Young Adult Population Open
Background: Adolescent and young adult cancer patients are at high risk of developing radiation-associated side effects after treatment. Proton beam radiation therapy might reduce the risk of these side effects for this population without …