Umberto Basile
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View article: Assessment of Cardiorenal Involvement in Systemic Sclerosis Patients
Assessment of Cardiorenal Involvement in Systemic Sclerosis Patients Open
Systemic sclerosis (SSc) is an autoimmune disease associated with a high burden of morbidity and mortality due to organ complications. Pulmonary arterial hypertension (PAH) and cardiac involvement, characterized by chronic right ventricula…
View article: Cryoproteins in Non-HCV-Related Autoimmune Disorders: A Serious Cold-Induced Problem
Cryoproteins in Non-HCV-Related Autoimmune Disorders: A Serious Cold-Induced Problem Open
The precipitation of cryoglobulins, serum immunoglobulins, below 37 °C defines the clinical cryoglobulinemic syndrome, a systemic vasculitis usually characterized by purpura, weakness, and arthralgia. In most cases, this condition is assoc…
View article: Distinct Biomarker Profiles of B-Cell Activation in Metabolic and Viral Hepatic Fibrosis
Distinct Biomarker Profiles of B-Cell Activation in Metabolic and Viral Hepatic Fibrosis Open
Increasing evidence underlines the role of B-cells in the development of hepatic fibrogenesis following viral infections and metabolic dysfunction, through different mechanisms depending on the etiology. Circulating biomarkers of B-cell ac…
View article: Serum Calprotectin as a Novel Biomarker of Disease Severity and Activity in Systemic Sclerosis Patients
Serum Calprotectin as a Novel Biomarker of Disease Severity and Activity in Systemic Sclerosis Patients Open
A monocentric cross-sectional study was performed to investigate the role of serum calprotectin as a biomarker for disease severity and activity in systemic sclerosis (SSc). Serum calprotectin was measured in 74 consecutive SSc patients ad…
View article: The entrenchment of NLRP3 inflammasomes in autoimmune disease-related inflammation
The entrenchment of NLRP3 inflammasomes in autoimmune disease-related inflammation Open
Autoinflammation and autoimmunity are almost "opposite" phenomena characterized by chronic activation of the immune system, 'innate' in the first and 'adaptive' in the second, leading to inflammation of several tissues with specific protea…
View article: Serum levels of free light chains and syndecan-1 in patients with rheumatoid arthritis and systemic lupus erythematosus
Serum levels of free light chains and syndecan-1 in patients with rheumatoid arthritis and systemic lupus erythematosus Open
Objectives Systemic autoimmune rheumatic diseases (SARDs) are characterized by chronic inflammation. Reliable biomarkers are crucial for diagnosis, monitoring disease progression and therapeutic responses. This study explores serum syndeca…
View article: The Evolution of Serological Assays during Two Years of the COVID-19 Pandemic: From an Easy-to-Use Screening Tool for Identifying Current Infections to Laboratory Algorithms for Discovering Immune Protection and Optimizing Vaccine Administration
The Evolution of Serological Assays during Two Years of the COVID-19 Pandemic: From an Easy-to-Use Screening Tool for Identifying Current Infections to Laboratory Algorithms for Discovering Immune Protection and Optimizing Vaccine Administration Open
The emergence of COVID-19 has evolved into a global pandemic, causing an unprecedented public health crisis marked by unprecedented levels of morbidity never seen in the recent past. Considerable research efforts have been made in the scie…
View article: New Biomarkers in Liver Fibrosis: A Pass through the Quicksand?
New Biomarkers in Liver Fibrosis: A Pass through the Quicksand? Open
Chronic liver diseases (CLD) stem from various causes and lead to a gradual progression that ultimately may result in fibrosis and eventually cirrhosis. This process is typically prolonged and asymptomatic, characterized by the complex int…
View article: Serum‐free light chains as a dependable biomarker for stratifying patients with metabolic dysfunction‐associated steatotic liver disease
Serum‐free light chains as a dependable biomarker for stratifying patients with metabolic dysfunction‐associated steatotic liver disease Open
Background and Aims Adaptive immunity is gaining a significant role in progression of metabolic dysfunction‐associated steatotic liver disease (MASLD). B‐cell activity can be assessed by serum‐free light chains (sFLCs) k and λ levels. The …
View article: Tumor Necrosis Factor-Alpha: Ally and Enemy in Protean Cutaneous Sceneries
Tumor Necrosis Factor-Alpha: Ally and Enemy in Protean Cutaneous Sceneries Open
Skin is the forestage for a series of many-sided functions of tumor necrosis factor-alpha (TNF-α), a proinflammatory cytokine with staggering versatility and sizable implications for tissue homeostasis, immune responses, angiogenesis, apop…
View article: Thymic stromal lymphopoietin and digital microvascular damage in systemic sclerosis patients: A pilot study
Thymic stromal lymphopoietin and digital microvascular damage in systemic sclerosis patients: A pilot study Open
TSLP might have a key role in digital microvascular damage of SSc patients.
View article: Hypovitaminosis D and Leukocytosis to Predict Cardiovascular Abnormalities in Children with Kawasaki Disease: Insights from a Single-Center Retrospective Observational Cohort Study
Hypovitaminosis D and Leukocytosis to Predict Cardiovascular Abnormalities in Children with Kawasaki Disease: Insights from a Single-Center Retrospective Observational Cohort Study Open
Introduction: An aberrant immune response involving yet unidentified environmental and genetic factors plays a crucial role in triggering Kawasaki disease (KD). Aims: The aim of this study was to assess general and laboratory data at the o…
View article: Spotlight on Syndecan 1 Role in Systemic Autoimmune Rheumatic Diseases: Main Actor or Guest Appearance?
Spotlight on Syndecan 1 Role in Systemic Autoimmune Rheumatic Diseases: Main Actor or Guest Appearance? Open
Background: Systemic autoimmune rheumatic diseases (SARDs), including Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA), are characterized by chronic inflammation and autoimmunity. Identifying reliable biomarkers is crucial …
View article: Salivary biomarkers in COVID-19 patients: the rabbit out of the hat!
Salivary biomarkers in COVID-19 patients: the rabbit out of the hat! Open
Background: The ongoing outbreak of Coronavirus Disease 2019 (COVID-19) represents a major threat to human health, which impairs the functionality of several organs. One of the hardest challenges in the fight against COVID-19 is the develo…
View article: Serum Neurofilament and Free Light Chain Levels in Patients Undergoing Treatment for Chronic Inflammatory Demyelinating Polyneuropathy
Serum Neurofilament and Free Light Chain Levels in Patients Undergoing Treatment for Chronic Inflammatory Demyelinating Polyneuropathy Open
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated disorder affecting the peripheral nervous system. Despite the established diagnostic criteria, monitoring disease activity and treatment remains challen…
View article: Kidney Biopsy and Immuno-Rheumatological Diseases: A Retrospective and Observational Study
Kidney Biopsy and Immuno-Rheumatological Diseases: A Retrospective and Observational Study Open
Renal involvement is a common occurrence in patients with immuno-rheumatological diseases (IRDs). Several instances of glomerulonephritis (GN) occur in the setting of IRD and complicate the clinical course of an underlying condition. The a…
View article: NLRP3 Inflammasome Involvement in Heart, Liver, and Lung Diseases—A Lesson from Cytokine Storm Syndrome
NLRP3 Inflammasome Involvement in Heart, Liver, and Lung Diseases—A Lesson from Cytokine Storm Syndrome Open
Inflammation and inflammasomes have been proposed as important regulators of the host–microorganism interaction, playing a key role in morbidity and mortality due to the coronavirus disease 2019 (COVID-19) in subjects with chronic conditio…
View article: In Systemic Sclerosis Patients, Peripheral Blood CD21low B Cells and Serum IL-4 and IL-21 Influence Joint Involvement
In Systemic Sclerosis Patients, Peripheral Blood CD21low B Cells and Serum IL-4 and IL-21 Influence Joint Involvement Open
Systemic sclerosis (SSc) patients have an increased frequency of CD21low B cells and of serum interleukin-4 (IL-4) and IL-21, each possible markers of joint involvement in inflammatory arthritis. The aim of this study was to investigate th…
View article: Calprotectin: two sides of the same coin
Calprotectin: two sides of the same coin Open
Calprotectin (CLP) is a calcium-binding protein produced by neutrophils and monocytes in the course of inflammation. Today, the role of faecal CLP in chronic IBD is well known, but in recent years attention has shifted towards circulating …
View article: Serological and Molecular Characterization of Hepatitis C Virus-Related Cryoglobulinemic Vasculitis in Patients without Cryoprecipitate
Serological and Molecular Characterization of Hepatitis C Virus-Related Cryoglobulinemic Vasculitis in Patients without Cryoprecipitate Open
Prolonged B cells stimulation due to the Hepatitis C virus (HCV) can result in autoimmunity, stigmatized by rising levels of cryoglobulins (CGs), the rheumatoid factor (RF), and free light chains (FLC) of immunoglobulins (Ig) associated wi…
View article: Elevated serum polyclonal immunoglobulin free light chains in patients with severe asthma
Elevated serum polyclonal immunoglobulin free light chains in patients with severe asthma Open
Background: Inflammation plays a pivotal role in the pathophysiology of asthma. Free light chains (FLC) can cause inflammation by mast cell antigen-activation. Serum immunoglobulin (Ig) FLC κ, but not λ, were shown elevated in adult males …
View article: POS1268 TYPE 2 (TH2) CYTOKINES AND SCLERODERMA INTERSTITIAL LUNG DISEASE (SSC-ILD)
POS1268 TYPE 2 (TH2) CYTOKINES AND SCLERODERMA INTERSTITIAL LUNG DISEASE (SSC-ILD) Open
Background Systemic sclerosis (SSc) is an autoimmune disease characterized by immune system dysregulation, endothelial dysfunction and fibrosis of skin and internal organs. Interstitial lung disease (ILD) is common in SSc and about 80% of …
View article: Laboratory and Clinical Settings of Heavy/Light Chain (HLC) Assays in the Management of Monoclonal Gammopathies and Multiple Myeloma
Laboratory and Clinical Settings of Heavy/Light Chain (HLC) Assays in the Management of Monoclonal Gammopathies and Multiple Myeloma Open
The antibody-related immune response is mediated by immunoglobulins (Igs), soluble circulating glycoproteins produced by activated B cells that, upon the recognition of specific epitopes on pathogen surfaces, activate, proliferate, and dif…
View article: Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients
Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients Open
Objectives: To assess serum immunoglobulin G (IgG) subclasses in a cohort of systemic sclerosis (SSc) patients and to evaluate the influence of IgG subclasses in the main complications of the disease. Methods: The serum level of IgG subcla…
View article: Cytokines and Hepatocellular Carcinoma: Biomarkers of a Deadly Embrace
Cytokines and Hepatocellular Carcinoma: Biomarkers of a Deadly Embrace Open
Hepatocellular carcinoma (HCC) represents a worldwide health matter with a major care burden, high prevalence, and poor prognosis. Its pathogenesis mainly varies depending on the underlying etiological factors, although it develops from li…