Umberto Morbiducci
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View article: Enhanced coronary physiology assessment with endothelial shear stress predicts residual cardiovascular risk in older patients with myocardial infarction
Enhanced coronary physiology assessment with endothelial shear stress predicts residual cardiovascular risk in older patients with myocardial infarction Open
TSVI, rather than absolute ESS magnitude, plays a key role in predicting acute events in older MI patients with MVD. Integrating ESS-based factors with traditional clinical and anatomical factors significantly enhances risk prediction and …
View article: Real-time beat-to-beat pulse wave velocity estimation: a quality-driven approach using laser Doppler vibrometry
Real-time beat-to-beat pulse wave velocity estimation: a quality-driven approach using laser Doppler vibrometry Open
Arterial stiffness, a key cardiovascular risk marker, is typically assessed via carotid-femoral pulse wave velocity (cf-PWV), the gold-standard method. In this study, we introduce CAPE (Continuous Automatic PWV Estimation), an innovative f…
View article: Artificial Intelligence-based Approaches for Characterizing Plaque Components From Intravascular Optical Coherence Tomography Imaging: Integration Into Clinical Decision Support Systems
Artificial Intelligence-based Approaches for Characterizing Plaque Components From Intravascular Optical Coherence Tomography Imaging: Integration Into Clinical Decision Support Systems Open
Intravascular optical coherence tomography (IVOCT) is emerging as an effective imaging technique for accurately characterizing coronary atherosclerotic plaques. This technique provides detailed information on plaque morphology and composit…
View article: The Anatomy of Coronary Risk: How Artery Geometry Shapes Coronary Artery Disease through Blood Flow Haemodynamics -- Latest Methods, Insights and Clinical Implications
The Anatomy of Coronary Risk: How Artery Geometry Shapes Coronary Artery Disease through Blood Flow Haemodynamics -- Latest Methods, Insights and Clinical Implications Open
Despite tremendous advances in cardiovascular medicine, significant opportunities remain to improve coronary artery disease (CAD) prevention and treatment strategies. The key limitation lies in the understanding of disease formation and pr…
View article: Adverse cardiovascular events in coronary Plaques not undeRgoing pErcutaneous coronary intervention evaluateD with optIcal Coherence Tomography. The PREDICT-AI risk model
Adverse cardiovascular events in coronary Plaques not undeRgoing pErcutaneous coronary intervention evaluateD with optIcal Coherence Tomography. The PREDICT-AI risk model Open
Introduction Most acute coronary syndromes (ACS) originate from coronary plaques that are angiographically mild and not flow limiting. These lesions, often characterised by thin-cap fibroatheroma, large lipid cores and macrophage infiltrat…
View article: Exploring the association between coronary vascular anatomical features and future myocardial infarction through statistical shape modelling
Exploring the association between coronary vascular anatomical features and future myocardial infarction through statistical shape modelling Open
Considering the intricate interplay among coronary anatomy and hemodynamics in coronary artery disease (CAD), anatomy-based descriptors have been employed as surrogates of local aberrant hemodynamics and, ultimately, as clinical markers fo…
View article: Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts
Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts Open
Background Bypass surgery using saphenous vein (SV) grafts is commonly performed to revascularize the ischemic heart and lower limbs. These interventions have limited success due to adverse remodeling caused by overproliferation of smooth …
View article: Impact of circuit configuration on the mechanical performance of CPAP therapy devices: an experimental study
Impact of circuit configuration on the mechanical performance of CPAP therapy devices: an experimental study Open
Introduction CPAP therapy treats various respiratory disorders. The overall performance of therapy delivery can be affected by the adopted circuit configuration. Recently, parallel to the canonical open configuration (OC), closed configura…
View article: Microcirculatory Resistance After Primary Percutaneous Coronary Intervention Predicts Residual Myocardial Damage and Scar Formation
Microcirculatory Resistance After Primary Percutaneous Coronary Intervention Predicts Residual Myocardial Damage and Scar Formation Open
Background Coronary microvascular dysfunction has been associated with adverse cardiovascular events following acute myocardial infarction. This study evaluates the role of the angiography‐derived index of microcirculatory resistance (angi…
View article: Outcomes of coronary artery aneurysms: insights from the Coronary Artery Ectasia and Aneurysm Registry (CAESAR)
Outcomes of coronary artery aneurysms: insights from the Coronary Artery Ectasia and Aneurysm Registry (CAESAR) Open
BACKGROUND: Coronary artery ectasias and aneurysms (CAE/CAAs) are among the less common forms of coronary artery disease, with undefined long-term outcomes and treatment strategies. AIMS: To assess the clinical characteristics, angiographi…
View article: Easy-to-use formulations based on the homogenization theory for vascular stent design and mechanical characterization
Easy-to-use formulations based on the homogenization theory for vascular stent design and mechanical characterization Open
The proposed method offers a rapid, fully automated procedure that facilitates the assessment of the mechanical behavior of vascular stents and is suitable for effective integration into computational optimization frameworks.
View article: Pathophysiology of the ascending aorta: Impact of dilation and valve phenotype on large-scale blood flow coherence detected by 4D flow MRI
Pathophysiology of the ascending aorta: Impact of dilation and valve phenotype on large-scale blood flow coherence detected by 4D flow MRI Open
The findings of this study can contribute to broaden the current mechanistic link between large-scale blood flow coherence and aortic pathophysiology, with the prospect of enriching the existing tools for the in vivo non-invasive hemodynam…
View article: Designing the mechanical behavior of NiTi self-expandable vascular stents by tuning the heat treatment parameters
Designing the mechanical behavior of NiTi self-expandable vascular stents by tuning the heat treatment parameters Open
The remarkable mechanical properties of nickel-titanium (NiTi) shape memory alloy, particularly its super-elasticity, establish it as the material of choice for fabricating self-expanding vascular stents, including the metallic backbone of…
View article: Fluid-structure interaction simulation of mechanical aortic valves: a narrative review exploring its role in total product life cycle
Fluid-structure interaction simulation of mechanical aortic valves: a narrative review exploring its role in total product life cycle Open
Over the last years computer modelling and simulation has emerged as an effective tool to support the total product life cycle of cardiovascular devices, particularly in the device preclinical evaluation and post-market assessment. Computa…
View article: An innovative artificial intelligence-based method to compress complex models into explainable, model-agnostic and reduced decision support systems with application to healthcare (NEAR)
An innovative artificial intelligence-based method to compress complex models into explainable, model-agnostic and reduced decision support systems with application to healthcare (NEAR) Open
An explainable and reliable CDSS tailored to single-patient analysis has been developed. The proposed AI-based system has the potential to be used alongside the clinical guidelines currently employed in the medical setting making them more…
View article: Smartphone-based particle tracking velocimetry for the in vitro assessment of coronary flows
Smartphone-based particle tracking velocimetry for the in vitro assessment of coronary flows Open
The present study adopts a smartphone-based approach for the experimental characterization of coronary flows. Technically, particle tracking velocimetry (PTV) measurements were performed using a smartphone camera and a low-power continuous…
View article: Predicting Lipid-Rich Plaque Progression in Coronary Arteries Using Multimodal Imaging and Wall Shear Stress Signatures
Predicting Lipid-Rich Plaque Progression in Coronary Arteries Using Multimodal Imaging and Wall Shear Stress Signatures Open
BACKGROUND: Plaque composition and wall shear stress (WSS) magnitude act as well-established players in coronary plaque progression. However, WSS magnitude per se does not completely capture the mechanical stimulus to which the endothelium…
View article: Plaque progression is dependent on the local hemodynamics (time-averaged wall shear stress and TSVI) in combination with the plaque phenotype
Plaque progression is dependent on the local hemodynamics (time-averaged wall shear stress and TSVI) in combination with the plaque phenotype Open
Objective To investigate the predictive power of TSVI for plaque growth in human coronary arteries in plaques with different phenotypes. Methods 38 non-stented, non-culprit coronary arteries (MPACT study) were imaged with near-infrared spe…
View article: Blood Flow Energy Identifies Coronary Lesions Culprit of Future Myocardial Infarction
Blood Flow Energy Identifies Coronary Lesions Culprit of Future Myocardial Infarction Open
The present study establishes a link between blood flow energy transformations in coronary atherosclerotic lesions and clinical outcomes. The predictive capacity for future myocardial infarction (MI) was compared with that of established q…
View article: Modelling blood flow in coronary arteries: Newtonian or shear-thinning non-Newtonian rheology?
Modelling blood flow in coronary arteries: Newtonian or shear-thinning non-Newtonian rheology? Open
This study, performed on 288 angio-based CFD simulations on 144 RCA models presenting with different degrees of stenosis, suggests that the assumptions on blood rheology have negligible impact both on WSS and helical flow profiles associat…
View article: Computational fluid dynamics as supporting technology for coronary artery disease diagnosis and treatment: an international survey
Computational fluid dynamics as supporting technology for coronary artery disease diagnosis and treatment: an international survey Open
Background Computational fluid dynamics (CFD) is emerging as an effective technology able to improve procedural outcomes and enhance clinical decision-making in patients with coronary artery disease (CAD). The present study aims to assess …
View article: Design of innovative self-expandable femoral stents using inverse homogenization topology optimization
Design of innovative self-expandable femoral stents using inverse homogenization topology optimization Open
In this study, we propose a novel computational framework for designing innovative self-expandable femoral stents. First, a two-dimensional stent unit cell is designed by inverse homogenization topology optimization. In particular, the uni…
View article: Impact of wall displacements on the large-scale flow coherence in ascending aorta
Impact of wall displacements on the large-scale flow coherence in ascending aorta Open
In the context of aortic hemodynamics, uncertainties affecting blood flow simulations hamper their translational potential as supportive technology in clinics. Computational fluid dynamics (CFD) simulations under rigid-walls assumption are…