Umer Akbar
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View article: Effect of fornix stimulation on acute memory encoding
Effect of fornix stimulation on acute memory encoding Open
Electrical stimulation of different nodes within the Circuit of Papez has been assessed in a variety of human studies with conflicting or indeterminate results. Our goal was to combine a precise psychophysical paradigm with varying stimula…
View article: Experience from a Fast-Track Multidisciplinary Clinic Integrating Movement Disorders Neurologists in Normal Pressure Hydrocephalus Evaluation
Experience from a Fast-Track Multidisciplinary Clinic Integrating Movement Disorders Neurologists in Normal Pressure Hydrocephalus Evaluation Open
In this prospective observational cohort study, we provide preliminary findings from a same-day multidisciplinary fast-tracked normal pressure hydrocephalus (NPH) clinic; incorporating the expertise of movement disorders neurologists, emph…
View article: Current Status of Integrated Palliative Care Among Parkinson Foundation Centers of Excellence in the United States
Current Status of Integrated Palliative Care Among Parkinson Foundation Centers of Excellence in the United States Open
These results demonstrate the emergence of structures and processes to provide PC to persons with PD at COEs. They also identify concrete opportunities to strengthen integration of PC through educational, quality improvement, and advocacy …
View article: 16 Relative Contributions of Motor and Non-Motor Symptoms to Caregiver Burden in Parkinson’s Disease Patients Being Evaluated for Deep Brain Stimulation
16 Relative Contributions of Motor and Non-Motor Symptoms to Caregiver Burden in Parkinson’s Disease Patients Being Evaluated for Deep Brain Stimulation Open
Objective: Parkinson’s disease (PD) is a neurodegenerative disorder affecting over 10 million people worldwide. PD is characterized by both motor (e.g., tremor, rigidity, and bradykinesia) and non-motor (including cognitive impairment and …
View article: Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease
Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease Open
Parkinson’s disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously. Understanding the neurophysiological correlates of these motor states could facilitate monitoring of disease progression and allow imp…
View article: Inpatient Mortality in Parkinson’s Disease
Inpatient Mortality in Parkinson’s Disease Open
Introduction Although a majority of the American public prefer to die at home, a large percentage of Parkinson’s disease patients die in acute care hospitals. We examine trends in the clinical and demographic characteristics of Parkinson’s…
View article: Author response: Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease
Author response: Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Parkins…
View article: iTex Gloves: Design and In-Home Evaluation of an E-Textile Glove System for Tele-Assessment of Parkinson’s Disease
iTex Gloves: Design and In-Home Evaluation of an E-Textile Glove System for Tele-Assessment of Parkinson’s Disease Open
Parkinson’s disease (PD) is a neurological progressive movement disorder, affecting more than 10 million people globally. PD demands a longitudinal assessment of symptoms to monitor the disease progression and manage the treatments. Existi…
View article: Decoding Dynamically Shifting States of Parkinson’s Disease: Tremor, Bradykinesia, and Effective Motor Control
Decoding Dynamically Shifting States of Parkinson’s Disease: Tremor, Bradykinesia, and Effective Motor Control Open
Parkinson’s Disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously. Understanding the neurophysiological correlates of these different motor states could facilitate monitoring of disease progression and…
View article: Subthalamic–Cortical Network Reorganization during Parkinson's Tremor
Subthalamic–Cortical Network Reorganization during Parkinson's Tremor Open
Tremor, a common and often primary symptom of Parkinson's disease, has been modeled with distinct onset and maintenance dynamics. To identify the neurophysiologic correlates of each state, we acquired intraoperative cortical and subthalami…
View article: Prognostic predictors relevant to end-of-life palliative care in Parkinson’s disease and related disorders: a systematic review
Prognostic predictors relevant to end-of-life palliative care in Parkinson’s disease and related disorders: a systematic review Open
Parkinson’s disease and related disorders (PDRD) are the second most common neurodegenerative disease and a leading cause of death. However, patients with PDRD receive less end-of-life palliative care (hospice) than other illnesses, includ…
View article: Subthalamic-Cortical Network Reorganization during Parkinson’s Tremor
Subthalamic-Cortical Network Reorganization during Parkinson’s Tremor Open
Tremor, a common and often primary symptom of Parkinson’s disease, has been modeled with distinct onset and maintenance dynamics. To identify the neurophysiologic correlates of each state, we acquired intraoperative cortical and subthalami…
View article: Multi-Dimensional, Short-Timescale Quantification of Parkinson's Disease and Essential Tremor Motor Dysfunction
Multi-Dimensional, Short-Timescale Quantification of Parkinson's Disease and Essential Tremor Motor Dysfunction Open
Introduction: Parkinson's disease (PD) is a progressive movement disorder characterized by heterogenous motor dysfunction with fluctuations in severity. Objective, short-timescale characterization of this dysfunction is necessary as therap…
View article: Rapid motor fluctuations reveal short-timescale neurophysiological biomarkers of Parkinson’s disease
Rapid motor fluctuations reveal short-timescale neurophysiological biomarkers of Parkinson’s disease Open
Objective. Identifying neural activity biomarkers of brain disease is essential to provide objective estimates of disease burden, obtain reliable feedback regarding therapeutic efficacy, and potentially to serve as a source of control for …
View article: Rapid Motor Fluctuations Reveal Short-Timescale Neurophysiological Biomarkers of Parkinson’s Disease
Rapid Motor Fluctuations Reveal Short-Timescale Neurophysiological Biomarkers of Parkinson’s Disease Open
Identifying neural activity biomarkers of brain disease is essential to provide objective estimates of disease burden, obtain reliable feedback regarding therapeutic efficacy, and potentially to serve as a source of control for closed-loop…
View article: Square Biphasic Pulse Deep Brain Stimulation for Parkinson’s Disease: The BiP-PD Study
Square Biphasic Pulse Deep Brain Stimulation for Parkinson’s Disease: The BiP-PD Study Open
Biphasic pulses were well-tolerated and provided similar benefit to conventional DBS. Further studies should address effectiveness of sqBIP in select PD patients.
View article: Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics
Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics Open
The annual deep brain stimulation (DBS) Think Tank aims to create an opportunity for a multidisciplinary discussion in the field of neuromodulation to examine developments, opportunities and challenges in the field. The proceedings of the …
View article: The Clinical and Ethical Practice of Neuromodulation – Deep Brain Stimulation and Beyond
The Clinical and Ethical Practice of Neuromodulation – Deep Brain Stimulation and Beyond Open
Frontiers is more than just an open-
View article: Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies
Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies Open
This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think…
View article: Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies
Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies Open
The proceedings of the 3rd Annual Deep Brain Stimulation Think Tank summarize the most contemporary clinical, electrophysiological, imaging, and computational work on DBS for the treatment of neurological and neuropsychiatric disease. Sign…