Umer Javed Butt
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View article: Erythropoietin reshapes the adult hippocampal chromatin landscape to promote neurogenesis
Erythropoietin reshapes the adult hippocampal chromatin landscape to promote neurogenesis Open
Understanding the molecular mechanisms by which erythropoietin (EPO) acts as neurotrophic factor that enhances hippocampal function and learning is essential to harness its therapeutic potential. Here, we employ single-nucleus ATAC-seq and…
View article: Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors
Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors Open
The procognitive growth factor erythropoietin (EPO) and its canonical receptor, EPOR, have long been recognized to be expressed by most cell types in the brain. Cognitive domains, improved by injections of exogenous EPO or by endogenous, h…
View article: Transcriptional dynamics of the oligodendrocyte lineage and its regulation by the brain erythropoietin system
Transcriptional dynamics of the oligodendrocyte lineage and its regulation by the brain erythropoietin system Open
Oligodendrocytes differentiate from oligodendrocyte progenitor cells (OPC) in early postnatal development, but some oligodendrogenesis is maintained throughout adulthood, where oligodendrocyte lineage dynamics may contribute to neuroplasti…
View article: Erythropoietin alleviates intellectual disability and autism-like behavior of mice caused by <i>Zbtb20</i> haploinsufficiency, a construct-valid model of Primrose syndrome
Erythropoietin alleviates intellectual disability and autism-like behavior of mice caused by <i>Zbtb20</i> haploinsufficiency, a construct-valid model of Primrose syndrome Open
Among the known genetic causes of syndromic autism spectrum disorders (ASD) are transcription factor deficiencies. In this regard, haploinsufficiency of the ‘zinc finger and broad complex, tramtrack, bric and brac domain-containing protein…
View article: Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors
Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors Open
The procognitive growth factor erythropoietin (EPO) and its canonical receptor, EPOR, have long been recognized to be expressed by most cell types in the brain. Cognitive domains, improved by injections of exogenous EPO or by endogenous, h…
View article: A comprehensive and standardized pipeline for automated profiling of higher cognition in mice
A comprehensive and standardized pipeline for automated profiling of higher cognition in mice Open
In rodent behavior research, observer-independent methods, such as the IntelliCage, enhance data collection in a social, and thus stress-reduced, environment. The IntelliCage system allows experimenters to create cognitive challenges for m…
View article: Tolerability and first hints for potential efficacy of motor‐cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders: A translational viewpoint
Tolerability and first hints for potential efficacy of motor‐cognitive training under inspiratory hypoxia in health and neuropsychiatric disorders: A translational viewpoint Open
Hypoxia is more and more perceived as pivotal physiological driving force, allowing cells in the brain and elsewhere to acclimate to lowered oxygen (O 2 ), and abridged metabolism. The mediating transcription program is induced by inspirat…
View article: IntelliR: A comprehensive and standardized pipeline for automated profiling of higher cognition in mice
IntelliR: A comprehensive and standardized pipeline for automated profiling of higher cognition in mice Open
In the rapidly evolving field of rodent behavior research, observer-independent methods facilitate data collection within a social, stress-reduced, and thus more natural environment. A prevalent system in this research area is the IntelliC…
View article: Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance
Introducing the brain erythropoietin circle to explain adaptive brain hardware upgrade and improved performance Open
Preface Executive functions, learning, attention, and processing speed are imperative facets of cognitive performance, affected in neuropsychiatric disorders. In clinical studies on different patient groups, recombinant human (rh) erythrop…
View article: NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression
NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression Open
Objectives Non-alcoholic fatty liver disease (NAFLD) can persist in the stage of simple hepatic steatosis or progress to steatohepatitis (NASH) with an increased risk for cirrhosis and cancer. We examined the mechanisms controlling the pro…
View article: CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge
CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge Open
We previously introduced the brain erythropoietin (EPO) circle as a model to explain the adaptive ‘brain hardware upgrade’ and enhanced performance. In this fundamental circle, brain cells, challenged by motor-cognitive tasks, experience f…
View article: Hippocampal neurons respond to brain activity with functional hypoxia
Hippocampal neurons respond to brain activity with functional hypoxia Open
Physical activity and cognitive challenge are established non-invasive methods to induce comprehensive brain activation and thereby improve global brain function including mood and emotional well-being in healthy subjects and in patients. …
View article: Cellular and transcriptional profiling of hypoxic cells in the brain
Cellular and transcriptional profiling of hypoxic cells in the brain Open
Hypoxia is a critical regulator of the hypoxic response driving neurodevelop-ment, angiogenesis, hematopoiesis, and tissue regeneration. In the central nervous system, oxygen is a fundamental constituent of cellular homeostasis and is tigh…
View article: Protective effects of <i>Nigella sativa L.</i> seed extract on lead induced neurotoxicity during development and early life in mouse models
Protective effects of <i>Nigella sativa L.</i> seed extract on lead induced neurotoxicity during development and early life in mouse models Open
Nigella sativa L. supplementation improves Pb-induced neurotoxicity in early life and provides neuroprotective and antioxidant potentials.