Syed Umer Jan
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View article: Design, Formulation Development and Characterization of Transdermal Patches Loaded with Pseudoephedrine and Loratadine
Design, Formulation Development and Characterization of Transdermal Patches Loaded with Pseudoephedrine and Loratadine Open
ABSTARCT Objective The purpose of this study was to develop the transdermal patch with a combination of pseudoephedrine HCL and Loratadine . Methodology Various formulations of these anti-anthetic drugs were prepared using Eudragit RL100 a…
View article: Formulation, Evaluation of Naproxen and Dexpanthenol Emulgel for Transdermal Drug Delivery
Formulation, Evaluation of Naproxen and Dexpanthenol Emulgel for Transdermal Drug Delivery Open
Objective: The aim of this study was to formulate emulgel of naproxen and dexpanthenol, a NSAID and complex of B vitamin, utilizing Carbapol 940 as a gelling agent. Mineral oil and clove oil were used as penetration enhancers.Methodology: …
View article: Development and Evaluation of Diclofenac Sodium Cream and Its Released Studies
Development and Evaluation of Diclofenac Sodium Cream and Its Released Studies Open
Objective: This study aimed to develop and evaluate diclofenac sodium cream and it’s in vitro rerelease studies with various enhancers.Methodology: Various formulations of diclofenac cream were developed with good solubility excipients and…
View article: DEVELOPMENT AND EVALAUTION OF LORATADINE GEL FOR TRANSDERMAL DRUG DELIVERY
DEVELOPMENT AND EVALAUTION OF LORATADINE GEL FOR TRANSDERMAL DRUG DELIVERY Open
Objective: This research was conducted to develop and evaluate sustained release topical gels containing Loratadine, olive oil used as penetration enhancer with various concentrations to see its effect on drug release concentration. Method…
View article: Formulation, Evaluation of Vitamin E Emulgel for Topical Application with Herbal Enhancers
Formulation, Evaluation of Vitamin E Emulgel for Topical Application with Herbal Enhancers Open
Vitamin E, an antioxidant with low water solubility and bioavailability, which can protect the skin from atopic dermatitis and other negative effects of sun radiation by scavenging free radicals. The current work aimed to establish and eva…
View article: Formulation, Characterization of Piroxicam Ointment for Topical Drug Delivery with various Enhancers
Formulation, Characterization of Piroxicam Ointment for Topical Drug Delivery with various Enhancers Open
The primary objective of the current study was to develop and then assess Piroxicam ointment with penetration enhancers, including castor oil, thymus oil, and clove oil. As per B. P., 4.750 g of hard paraffin was melted at sixty degrees Ce…
View article: Formulation Development And Pharmacokinetic Evaluation Of Celecoxib Loaded Hydroxyl Propyl Methyl Cellulose (HPMC) Microparticles In In-Vivo Model
Formulation Development And Pharmacokinetic Evaluation Of Celecoxib Loaded Hydroxyl Propyl Methyl Cellulose (HPMC) Microparticles In In-Vivo Model Open
This investigation aimed to formulate Celecoxib-loaded microparticles for targeted delivery to the colon, employing Hydroxypropylmethylcellulose (HPMC). Celecoxib’s effectiveness in managing colorectal cancer (CRC)-related pain and inflamm…
View article: Developed meloxicam loaded microparticles for colon targeted delivery: Statistical optimization, physicochemical characterization, and in-vivo toxicity study
Developed meloxicam loaded microparticles for colon targeted delivery: Statistical optimization, physicochemical characterization, and in-vivo toxicity study Open
The study aimed to fabricate and evaluate Meloxicam (MLX) loaded Hydroxypropyl Methylcellulose (HPMC) microparticles for colon targeting because MLX is a potent analgesic used in the treatment of pain and inflammation associated with color…
View article: Prescribing Patterns for Upper Respiratory Tract Infections: A Prescription-Review of Primary Care Practice in Quetta, Pakistan and the Implications
Prescribing Patterns for Upper Respiratory Tract Infections: A Prescription-Review of Primary Care Practice in Quetta, Pakistan and the Implications Open
Background: To identify and address the potential overuse of antibiotics, it is important to ascertain the prescribing practices of physicians. We, therefore, conducted this prescription analysis to document URTI-specific antibiotic prescr…
View article: RELATIVE COMPARISON OF STABILITY AND DEGRADATION OF METHYLCOBALAMIN TABLETS OF DIFFERENT BRANDS AT DIFFERENT STORAGE SETTINGS
RELATIVE COMPARISON OF STABILITY AND DEGRADATION OF METHYLCOBALAMIN TABLETS OF DIFFERENT BRANDS AT DIFFERENT STORAGE SETTINGS Open
Objective: To assess relative comparison of stability and degradation of Methylcobalamin tablets of different brands at various storage circumstances.
Methods: The comparative in vitro study of Methycobal (innovator brand) with its other …
View article: FORMULATION AND EVALUATION OF MEFENAMIC ACID OINTMENT USING PENETRATION ENHANCERS
FORMULATION AND EVALUATION OF MEFENAMIC ACID OINTMENT USING PENETRATION ENHANCERS Open
Objective: The aim of study was to formulate and evaluate Mefenamic acid ointment by the addition of penetration enhancer’s clove oil.
Methods: 1%, 2% and 3% formulations of Mefenamic acid ointment formulated as per B. P, by melting hard …
View article: Thiol-disulfide exchange reactions occurring at modified bovine serum albumin detected using ellman's reagent (5, 5'-dithiobis (2-itrobenzoic acid).
Thiol-disulfide exchange reactions occurring at modified bovine serum albumin detected using ellman's reagent (5, 5'-dithiobis (2-itrobenzoic acid). Open
Bovine serum albumin (BSA) is usually employed as a model protein because of being homologous with human serum albumin. Cysteine-34 of BSA has been oxidised with Ellman's reagent to produce BSA labelled with an Ellman's moiety (BSA-SE). Th…
View article: Frequency of Anxiety, Depression and Stress among Pharmacy Undergraduates of Annual and Semester System: A Cohort-Based Comparison
Frequency of Anxiety, Depression and Stress among Pharmacy Undergraduates of Annual and Semester System: A Cohort-Based Comparison Open
Objectives: The current study was aimed to evaluate the anxiety, depression and stress (AD&S) among two different academic performance systems (i.e. semester and annual system). Methods: A questionnaire— based, cross-sectional survey techn…
View article: FORMULATION AND EVALUATION OF GLIBENCLAMIDE GEL FOR TRANSDERMAL DRUG DELIVERY
FORMULATION AND EVALUATION OF GLIBENCLAMIDE GEL FOR TRANSDERMAL DRUG DELIVERY Open
Objective: The purpose of the recent study was to formulate glibenclamide gels for transdermal drug release, and to evaluate the oleic acid effect on the release of the preparations.
Methods: Oleic acid was used at a range of concentratio…
View article: FORMULATION AND EVALUATION OF CELECOXIB CREAM AND ITS RELEASED STUDY
FORMULATION AND EVALUATION OF CELECOXIB CREAM AND ITS RELEASED STUDY Open
Objective: The purpose of this study was to formulate and evaluate of Celecoxib cream and it’s in vitro release study.
Methods: The release study was conducted, using dialysis cellulose membrane, in Franz cells. The donor chamber was fill…
View article: Design, Preparation and evaluation of various parameters of controlled release matrices of losartan potassium using polymers combination.
Design, Preparation and evaluation of various parameters of controlled release matrices of losartan potassium using polymers combination. Open
Controlled release formulations are administered once a day and reduce frequency of dose and ensuring patient's compliance. In the current research controlled release matrices of losartan potassium formulated with polymeric combinations of…
View article: FORMULATION AND EVALUATION OF METFORMIN HCL RELEASE FROM TOPICAL PREPARATION USING TWO DIFFERENT TYPES OF MEMBRANE
FORMULATION AND EVALUATION OF METFORMIN HCL RELEASE FROM TOPICAL PREPARATION USING TWO DIFFERENT TYPES OF MEMBRANE Open
Objective: Present study was carried to formulate and evaluate the transdermal ointment containing the metformin HCl active ingredient and to assess their Physicochemical studies.
Methods: Metformin HCl ointment was prepared with various …
View article: FORMULATION OF MICROEMULSION BASED GEL OF SALBUTAMOL SULPHATE AND IT’S IN VITRO STUDIES
FORMULATION OF MICROEMULSION BASED GEL OF SALBUTAMOL SULPHATE AND IT’S IN VITRO STUDIES Open
Objective: The aim of this study was to develop a microemulsion based gel system considering transdermal delivery of Salbutamol with a purpose to increase the solubility and membrane drug deliverance.
Methods: Oleic acid was favored for o…
View article: Analgesic and neuropharmacological activities of Berberis lycium Royle collected from district Sherani Balochistan, Pakistan.
Analgesic and neuropharmacological activities of Berberis lycium Royle collected from district Sherani Balochistan, Pakistan. Open
Berberis lycium (family Berberidaceae) grows in district Sherani, Balochistan, Pakistan. It is used for the treatment of various disorders by the people of Balochistan. The present work was carried out to explore analgesic and neuropharamc…
View article: FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF PSEUDOEPHEDRINE HCL
FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF PSEUDOEPHEDRINE HCL Open
Objective: This study was conducted to design a transdermal dosage form of pseudoephedrine HCL and to evaluate its release under controlled rates for sustained transdermal delivery of Pseudoephedrine.
Methods: Transdermal patches were pre…
View article: Effect of Thyme Oil on the Transdermal Permeation of Pseudoephedrine HCl from Topical Gel
Effect of Thyme Oil on the Transdermal Permeation of Pseudoephedrine HCl from Topical Gel Open
The aims of the current study were to prepare pseudoephedrine gel formulations for skin permeability and to assess the effect of thyme oil on the permeability of the formulations.Thyme oil was used in the gel formulations at a range of con…
View article: Formulation of Hedera helix L. in Topical Dosage Forms: In Vitro and Ex Vivo Evaluation
Formulation of Hedera helix L. in Topical Dosage Forms: In Vitro and Ex Vivo Evaluation Open
Hedera helix L. is traditional herbal medicine used in the treatment of asthma.The main objective of this study was to formulate a microemulsion, a gel, and an ointment containing the ethanol extracts of H. helix L. and to evaluate in vitr…
View article: Formulations, characterization, in vitro and ex vivo release of Ephedra extract from topical preparations using dialysis cellulose membrane and natural rabbit skin
Formulations, characterization, in vitro and ex vivo release of Ephedra extract from topical preparations using dialysis cellulose membrane and natural rabbit skin Open
Ephedra is herbal medicine used in the treatment of many diseases, especially asthma and urticaria.The aim of this study was to formulate topical formulations as a microemulsion, a gel and an ointment containing the Ephedra extracts of (E.…
View article: Preliminary Phytochemical Screening, Quantitative Analysis of Alkaloids, and Antioxidant Activity of Crude Plant Extracts from<i> Ephedra intermedia</i> Indigenous to Balochistan
Preliminary Phytochemical Screening, Quantitative Analysis of Alkaloids, and Antioxidant Activity of Crude Plant Extracts from<i> Ephedra intermedia</i> Indigenous to Balochistan Open
The aim of this study was to evaluate the antioxidant activity, screening the phytogenic chemical compounds, and to assess the alkaloids present in the E. intermedia to prove its uses in Pakistani folk medicines for the treatment of asthma…
View article: EFFECT OF MERCURY ON REDUCED GLUTATHIONE OF HUMAN T AND B LYMPHOCYTES: A COMPARISON OF INORGANIC AND ORGANIC MERCURY
EFFECT OF MERCURY ON REDUCED GLUTATHIONE OF HUMAN T AND B LYMPHOCYTES: A COMPARISON OF INORGANIC AND ORGANIC MERCURY Open
Background: Environmental pollution of transition metals especially of mercury is of great concern to the researchers in medical field since long. Mercury causes oxidative stress in all the cells including lymphocytes of the human immune s…