Umer Rashid
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View article: Secondary metabolites isolated from Fernandoa adenophylla (Wall. ex G.Don) steenis as multitarget inhibitors of cholinesterases for the treatment of Alzheimer’s Disease, followed by molecular docking studies
Secondary metabolites isolated from Fernandoa adenophylla (Wall. ex G.Don) steenis as multitarget inhibitors of cholinesterases for the treatment of Alzheimer’s Disease, followed by molecular docking studies Open
Alzheimer’s disease (AD) is a neurodegenerative disorder categorized by the progressive loss of cognitive function, with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) as key therapeutic targets. In this study, we report the…
View article: Potential Anticancer Activity and Molecular Docking studies of Plant-derived Molecules from Fernandoa adenophylla against Glioblastoma (U87) Cell Line
Potential Anticancer Activity and Molecular Docking studies of Plant-derived Molecules from Fernandoa adenophylla against Glioblastoma (U87) Cell Line Open
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a dismal prognosis and limited treatment options. This study explores the anticancer potential of bioactive compounds isolated from Fernandoa adenophylla, a plant renown…
View article: Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease. Metabolites 2022, 12, 1055
Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease. Metabolites 2022, 12, 1055 Open
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View article: Thymidine Phosphorylase Inhibitory Potential and Molecular Docking Studies of Secondary Metabolites Isolated From <i>Fernandoa adenophylla</i> (Wall. ex G. Don) Steenis
Thymidine Phosphorylase Inhibitory Potential and Molecular Docking Studies of Secondary Metabolites Isolated From <i>Fernandoa adenophylla</i> (Wall. ex G. Don) Steenis Open
This study investigates the potential of Fernandoa adenophylla , a South American plant, as a reservoir of compounds with thymidine phosphorylase (TP) inhibitory activity. Through a comprehensive approach combining in vitro assays and mole…
View article: Synthesis, Pharmacological Evaluation, and Molecular Modeling of Phthalimide Derivatives as Monoamine Oxidase and Cholinesterase Dual Inhibitors
Synthesis, Pharmacological Evaluation, and Molecular Modeling of Phthalimide Derivatives as Monoamine Oxidase and Cholinesterase Dual Inhibitors Open
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia and cognitive decline, associated with synaptic loss and degeneration of cholinergic neurons. New multitarget inhibitors for monoamine oxidase (MAO) and cho…
View article: Aldose Reductase Inhibition, Molecular Docking, and Density Functional Theory Studies of Dinaphthodiospyrol H from Diospyros kaki (Japanese Persimmon)
Aldose Reductase Inhibition, Molecular Docking, and Density Functional Theory Studies of Dinaphthodiospyrol H from Diospyros kaki (Japanese Persimmon) Open
This study explores the aldose reductase (AR) inhibitory potential of dinaphthodiospyrol H, a compound isolated from Diospyros kaki (Japanese persimmon). Aldose reductase plays a crucial role in the polyol pathway, a key factor in the prog…
View article: Dihydropyrimidine-2-thione derivatives as SARS-CoV-2 main protease inhibitors: synthesis, SAR and <i>in vitro</i> profiling
Dihydropyrimidine-2-thione derivatives as SARS-CoV-2 main protease inhibitors: synthesis, SAR and <i>in vitro</i> profiling Open
Despite the passage of approximately five years since the outbreak, an efficacious remedy for SARS-CoV-2 remains elusive, highlighting the urgent imperative for developing SARS-CoV-2 potent inhibitors.
View article: CAS9 Mediated In‐Planta Defence Strategy Against Tomato Leaf Curl New Delhi Virus (ToLCNDV) in Tomato
CAS9 Mediated In‐Planta Defence Strategy Against Tomato Leaf Curl New Delhi Virus (ToLCNDV) in Tomato Open
Tomato leaf curl New Delhi virus (ToLCNDV), a begomovirus, that causes severe leaf curling, stunting, and reduced yield in tomato plants is consistently threatening its production worldwide. CRISPR/Cas9‐mediated genome editing has shown im…
View article: Exploration of novel triazolo-thiadiazine hybrids of deferasirox as multi-target-directed anti-neuroinflammatory agents with structure–activity relationship (SAR): a new treatment opportunity for Alzheimer's disease
Exploration of novel triazolo-thiadiazine hybrids of deferasirox as multi-target-directed anti-neuroinflammatory agents with structure–activity relationship (SAR): a new treatment opportunity for Alzheimer's disease Open
We present a thorough evaluation of deferasirox derivative drugs that can interact with many targets by utilizing a mix of several pharmacophores for Alzheimer's treatment.
View article: IMPACTS OF CLIMATE CHANGE AND FLOOD DISASTERS IN PAKISTAN
IMPACTS OF CLIMATE CHANGE AND FLOOD DISASTERS IN PAKISTAN Open
Ecosystems and human life depends on availability of water. Pakistan holds its 4th position for consuming of freshwater in the world. Pakistan is considered a water-stressed country and is rapidly approaching water scarcity. Pakistan may f…
View article: IMPACTS OF CLIMATE CHANGE AND FLOOD DISASTERS IN PAKISTAN
IMPACTS OF CLIMATE CHANGE AND FLOOD DISASTERS IN PAKISTAN Open
Ecosystems and human life depends on availability of water. Pakistan holds its 4th position for consuming of freshwater in the world. Pakistan is considered a water-stressed country and is rapidly approaching water scarcity. Pakistan may f…
View article: In vivo analgesic, anti-inflammatory, sedative, muscle relaxant activities, and docking studies of 3’,4’,7,8-tetrahydroxy-3-methoxyflavone isolated from Pistacia chinensis
In vivo analgesic, anti-inflammatory, sedative, muscle relaxant activities, and docking studies of 3’,4’,7,8-tetrahydroxy-3-methoxyflavone isolated from Pistacia chinensis Open
Background: Pistacia chinensis is extensively employed in traditional medicine. This study aimed to isolate and evaluate the therapeutic effects of 3’4’78-tetrahydroxy-3-methoxyflavone from P. chinensis crude extract. Materials and Methods…
Anti-inflammatory and anti-diabetic properties of indanone derivative isolated from Fernandoa adenophylla in vitro and in silico studies Open
Fernandoa adenophylla , due to the presence of phytochemicals, has various beneficial properties and is used in folk medicine to treat many conditions. This study aimed to isolate indanone derivative from F. adenophylla root heartwood and …
View article: In vivo effects of a selected thiourea derivative 1-(2-chlorobenzoyl)-3-(2,3-dichlorophenyl) against nociception, inflammation and gastric ulcerogenicity: Biochemical, histopathological and in silico approaches
In vivo effects of a selected thiourea derivative 1-(2-chlorobenzoyl)-3-(2,3-dichlorophenyl) against nociception, inflammation and gastric ulcerogenicity: Biochemical, histopathological and in silico approaches Open
The current study was designed to investigate the potential of a synthetic therapeutic agent for better management of pain and inflammation, exhibiting minimal to non-existent ulcerogenic effects. The effect of 1-(2-chlorobenzoyl)-3-(2,3-d…
View article: <i>In vitro</i> and <i>in silico</i> antiproliferative potential of isolated flavonoids constitutes from <i>Pistacia integerrima</i>
<i>In vitro</i> and <i>in silico</i> antiproliferative potential of isolated flavonoids constitutes from <i>Pistacia integerrima</i> Open
Cancer is one of the most demanding domains for innovative, effective, safe, and affordable therapeutically active chemicals. The main aim of this study is to research new phytochemicals with anticancer activity. The current experiment ide…
View article: Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and in vitro, in vivo, and in silico studies
Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and in vitro, in vivo, and in silico studies Open
Inflammation is a protective response to a variety of infectious agents. To develop a new anti-inflammatory drug, we explored a pharmacologically important thiazole scaffold in this study. In a multi-step synthetic approach, we synthesized…
View article: Pregnenolone derivatives for the treatment of Alzheimer's disease: synthesis, and <i>in vitro</i> inhibition of amyloid β <sub>1–42</sub> peptide aggregation, acetylcholinesterase and carbonic anhydrase-II
Pregnenolone derivatives for the treatment of Alzheimer's disease: synthesis, and <i>in vitro</i> inhibition of amyloid β <sub>1–42</sub> peptide aggregation, acetylcholinesterase and carbonic anhydrase-II Open
Pregnenolone-based derivatives have been synthesized to inhibit the protofibril formation in order to reduce Aβ 1–42 production and prevent its aggregation.
View article: Exploitation of the multitarget role of new ferulic and gallic acid derivatives in oxidative stress-related Alzheimer's disease therapies: design, synthesis and bioevaluation
Exploitation of the multitarget role of new ferulic and gallic acid derivatives in oxidative stress-related Alzheimer's disease therapies: design, synthesis and bioevaluation Open
Monoamine oxidases (MAOs) inhibitors could decrease reactive oxygen species (ROS) generation, enhance mono-aminergic neural transmission, and have major therapeutic benefits for the treatment of Alzheimer's disease (AD).
View article: Antileishmanial potential of thiourea-based derivatives: design, synthesis and biological activity
Antileishmanial potential of thiourea-based derivatives: design, synthesis and biological activity Open
The evaluation of the results showed that compounds 4g and 20a–b could be promising leads/hits to enrich the arsenal of antileishmanial drug development.
View article: Novel Coumarin Derivatives as Potential Urease Inhibitors for Kidney Stone Prevention and Antiulcer Therapy: From Synthesis to In Vivo Evaluation
Novel Coumarin Derivatives as Potential Urease Inhibitors for Kidney Stone Prevention and Antiulcer Therapy: From Synthesis to In Vivo Evaluation Open
The presence of ammonium ions in urine, along with basic pH in the presence of urease-producing bacteria, promotes the production of struvite stones. This causes renal malfunction, which is manifested by symptoms such as fever, nausea, vom…
View article: Prediction of Phytochemicals for Their Potential to Inhibit New Delhi Metallo β-Lactamase (NDM-1)
Prediction of Phytochemicals for Their Potential to Inhibit New Delhi Metallo β-Lactamase (NDM-1) Open
The effectiveness of all antibiotics in the β-lactam group to cure bacterial infections has been impaired by the introduction of the New Delhi Metallo-β-lactamase (NDM-1) enzyme. Attempts have been made to discover a potent chemical as an …
View article: Antiproliferative Activity of Lignans from Olea ferruginea: In Vitro Evidence Supported by Docking Studies
Antiproliferative Activity of Lignans from Olea ferruginea: In Vitro Evidence Supported by Docking Studies Open
Background: The aim of the current study was to investigate the anticancer potential of bioactive compounds isolated from the leaves of Olea ferruginea (O. ferruginea). Lignans from O. ferruginea were previously described to possess antiba…
View article: Metallofullerenes as Robust Single-Atom Catalysts for Adsorption and Dissociation of Hydrogen Molecules: A Density Functional Study
Metallofullerenes as Robust Single-Atom Catalysts for Adsorption and Dissociation of Hydrogen Molecules: A Density Functional Study Open
Hydrogen is currently considered as the best alternative for traditional fuels due to its sustainable and ecofriendly nature. Additionally, hydrogen dissociation is a critical step in almost all hydrogenation reactions, which is crucial in…
View article: Synthesis, in-vitro inhibition of cyclooxygenases and in silico studies of new isoxazole derivatives
Synthesis, in-vitro inhibition of cyclooxygenases and in silico studies of new isoxazole derivatives Open
Isoxazole belongs to the class of five-membered heterocyclic compounds. The process of developing new drugs has significantly gained attention due to inadequate pharmacokinetic and safety attributes of the available drugs. This study aimed…