Umesh D. Wankhade
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View article: Dietary Prebiotics Modulate Omeprazole‐Induced Alterations in the Gut Microbial Signature
Dietary Prebiotics Modulate Omeprazole‐Induced Alterations in the Gut Microbial Signature Open
Proton pump inhibitors (PPIs) are commonly used to treat heartburn and acid‐related disorders. However, their misuse and prolonged use contribute to gut dysbiosis. This study investigated whether well‐known prebiotic dietary sources, blueb…
View article: Impact of short-term housing temperature alteration on metabolic parameters and adipose tissue in female mice
Impact of short-term housing temperature alteration on metabolic parameters and adipose tissue in female mice Open
Introduction Ambient temperature significantly influences physiological and metabolic processes in rodents, affecting obesity and related disorders. Mice housed below thermoneutral temperatures exhibit increased energy expenditure and symp…
View article: Maternal high-fat diet-induced obesity in offspring: Unraveling adipose tissue dysfunction mediated by increased heat shock proteins
Maternal high-fat diet-induced obesity in offspring: Unraveling adipose tissue dysfunction mediated by increased heat shock proteins Open
Maternal weight and diet before and during pregnancy have a substantial impact on offspring metabolic health, though sex-specific differences in metabolic and adipose tissue adaptations to maternal overnutrition remain insufficiently under…
View article: The Transgenerational Inheritance of Obesity: Maternal High-Fat Diet Drives Inflammatory Transcriptomic Signatures in Offspring Adipose Tissue
The Transgenerational Inheritance of Obesity: Maternal High-Fat Diet Drives Inflammatory Transcriptomic Signatures in Offspring Adipose Tissue Open
View article: Lipocalin-2 Regulates Osteocyte Ferroptosis and Osteocyte-Osteoblast Crosstalk via Wnt Signaling to Control Bone Formation
Lipocalin-2 Regulates Osteocyte Ferroptosis and Osteocyte-Osteoblast Crosstalk via Wnt Signaling to Control Bone Formation Open
View article: Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation
Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation Open
Evidence suggests that a healthy gut microbiome is essential for metabolizing dietary phytochemicals. However, the microbiome's role in metabolite production and the influence of gut dysbiosis on this process remain unclear. Further, studi…
View article: Shared and distinct adaptations to early-life exercise training based on inborn fitness
Shared and distinct adaptations to early-life exercise training based on inborn fitness Open
Background Low cardiorespiratory fitness due to genetics increases the risk for cardiometabolic disease. Endurance exercise training promotes cardiorespiratory fitness and improves cardiometabolic risk factors, but with great heterogeneity…
View article: Impact of maternal high‐fat diet on offspring gut microbiota during short‐term high‐fat diet exposure in mice
Impact of maternal high‐fat diet on offspring gut microbiota during short‐term high‐fat diet exposure in mice Open
Alterations in the gut microbiome have been linked to obesity, with maternal high‐fat diet (HF) playing a role in shaping offspring microbiome composition. However, the sex‐specific responses to maternal HF diet and the impact of subsequen…
View article: Maternal Obesity Alters Adipogenic Potential and Mitochondrial Function in Mesenchymal Stem Cells From Infants Born to Mothers With Overweight or Obesity
Maternal Obesity Alters Adipogenic Potential and Mitochondrial Function in Mesenchymal Stem Cells From Infants Born to Mothers With Overweight or Obesity Open
View article: Maternal High-Fat Diet-Induced Obesity in Offspring: Unraveling Adipose Tissue Dysfunction Mediated by Increased Heat Shock Proteins
Maternal High-Fat Diet-Induced Obesity in Offspring: Unraveling Adipose Tissue Dysfunction Mediated by Increased Heat Shock Proteins Open
Objectives: Maternal weight and diet prior to and during pregnancy significantly affect offspring metabolic health. This study aimed to assess the sex-specific impact of maternal HFD-induced obesity on offspring adiposity, glucose metaboli…
View article: Effects of Statin and Annatto-extracted Tocotrienol Supplementation on Glucose Homeostasis, Bone Microstructure, and Gut Microbiota Composition in Obese Mice
Effects of Statin and Annatto-extracted Tocotrienol Supplementation on Glucose Homeostasis, Bone Microstructure, and Gut Microbiota Composition in Obese Mice Open
TT and statin collectively benefit bone microstructure, glucose homeostasis, and microbial ecology in obese mice. Such changes may be, in part, associated with suppression of inflammation in the host.
View article: Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes
Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N‐oxide by modulating gut microbes Open
Gut microbes play a pivotal role in host physiology by producing beneficial or detrimental metabolites. Gut bacteria metabolize dietary choline and L‐carnitine to trimethylamine (TMA) which is then converted to trimethylamine‐N‐oxide (TMAO…
View article: Dose- and Time-Dependent Effect of Dietary Blueberries on Diabetic Vasculature Is Correlated with Gut Microbial Signature
Dose- and Time-Dependent Effect of Dietary Blueberries on Diabetic Vasculature Is Correlated with Gut Microbial Signature Open
Evidence from our lab and others indicates the vascular effects of dietary blueberries. In the present study, we determined dietary blueberries’ dose- and time-dependent effects on diabetic vasculature and their association with gut microb…
View article: OR22-06-23 Gut Microbes and Dietary Composition Modulate the Production of Blueberry Derived Metabolites
OR22-06-23 Gut Microbes and Dietary Composition Modulate the Production of Blueberry Derived Metabolites Open
View article: OR15-01-23 Strawberry-Derived Microbial Metabolites and Gut Microbes Mediate the Beneficial Vascular Effects of Dietary Strawberries
OR15-01-23 Strawberry-Derived Microbial Metabolites and Gut Microbes Mediate the Beneficial Vascular Effects of Dietary Strawberries Open
View article: Beta‐adrenergic agonist induces unique transcriptomic signature in inguinal white adipose tissue
Beta‐adrenergic agonist induces unique transcriptomic signature in inguinal white adipose tissue Open
Activation of thermogenic adipose tissue depots has been linked to improved metabolism and weight loss. To study the molecular regulation of adipocyte thermogenesis, we performed RNA‐Seq on brown adipose tissue (BAT), gonadal white adipose…
View article: Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation
Gut Microbes Are Associated with the Vascular Beneficial Effects of Dietary Strawberry on Metabolic Syndrome‐Induced Vascular Inflammation Open
Scope Metabolic syndrome (MetS) alters the gut microbial ecology and increases the risk of cardiovascular disease. This study investigates whether strawberry consumption reduces vascular complications in an animal model of MetS and identif…
View article: Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge
Gut Microbiome and Metabolome Modulation by Maternal High-Fat Diet and Thermogenic Challenge Open
The gut microbiota plays a critical role in energy homeostasis and its dysbiosis is associated with obesity. Maternal high-fat diet (HFD) and β-adrenergic stimuli alter the gut microbiota independently; however, their collective regulation…
View article: Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice Open
Studies from both humans and animal models indicated that maternal chronic poor-quality diet, especially a high fat diet (HFD), is significantly associated with reduced bone density and childhood fractures in offspring. When previously stu…
View article: Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis Open
Ectopic ceramide accumulation in insulin-responsive tissues contributes to the development of obesity and impairs insulin sensitivity. Moreover, pharmacological inhibition of serine palmitoyl transferase (SPT), the first enzyme essential f…
View article: Dietary Conjugated Linoleic Acid Reduces Body Weight and Fat in Snord116m+/p− and Snord116m−/p− Mouse Models of Prader–Willi Syndrome
Dietary Conjugated Linoleic Acid Reduces Body Weight and Fat in Snord116m+/p− and Snord116m−/p− Mouse Models of Prader–Willi Syndrome Open
Prader–Willi Syndrome (PWS) is a human genetic condition that affects up to 1 in 10,000 live births. Affected infants present with hypotonia and developmental delay. Hyperphagia and increasing body weight follow unless drastic calorie rest…
View article: Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes
Dietary Blueberry Ameliorates Vascular Complications in Diabetic Mice Possibly through NOX4 and Modulates Composition and Functional Diversity of Gut Microbes Open
Scope In diabetes, endothelial inflammation and dysfunction play a pivotal role in the development of vascular disease. This study investigates the effect of dietary blueberries on vascular complications and gut microbiome in diabetic mice…
View article: Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice
Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice Open
Studies from both humans and animal models indicated that maternal chronic poor-quality diet, especially a high fat diet (HFD), is significantly associated with reduced bone density and childhood fractures in offspring. When previously stu…
View article: On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice
On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice Open
Myoglobin confers the distinct red color to muscle and heart, serving as an oxygen-binding protein in oxidative fibers. Less attention has been paid to brown fat, a thermogenic tissue that also expresses myoglobin. In a mouse knockout mode…
View article: A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice
A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice Open
The gut microflora is a vital component of the gastrointestinal (GI) system that regulates local and systemic immunity, inflammatory response, the digestive system, and overall health. Older people commonly suffer from inadequate nutrition…
View article: <scp>Short‐Term</scp> Increased Physical Activity During Early Life Affects High‐Fat <scp>Diet–Induced</scp> Bone Loss in Young Adult Mice
<span>Short‐Term</span> Increased Physical Activity During Early Life Affects High‐Fat <span>Diet–Induced</span> Bone Loss in Young Adult Mice Open
Mechanical stresses associated with physical activity (PA) have beneficial effects on increasing BMD and improving bone quality. However, a high‐fat diet (HFD) and obesity tend to have negative effects on bone, by increasing bone marrow ad…
View article: Author response for "Short‐Term Increased Physical Activity during Early Life Affects High Fat Diet‐Induced Bone Loss in Young Adult Mice"
Author response for "Short‐Term Increased Physical Activity during Early Life Affects High Fat Diet‐Induced Bone Loss in Young Adult Mice" Open
View article: Beige Adipose Tissue Identification and Marker Specificity—Overview
Beige Adipose Tissue Identification and Marker Specificity—Overview Open
Adipose tissue (AT) is classified based on its location, physiological and functional characteristics. Although there is a clear demarcation of anatomical and molecular features specific to white (WAT) and brown adipose tissue (BAT), the f…
View article: GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice Open
The G protein-coupled receptor 109 A (GPR109A) is robustly expressed in osteoclastic precursor macrophages. Previous studies suggested that GPR109A mediates effects of diet-derived phenolic acids such as hippuric acid (HA) and 3-(3-hydroxy…
View article: Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites
Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites Open
We debut a liquid chromatography-mass spectrometry (LC/MS) platform called the XenoScan, which is a metabolomics platform for xenometabolites (nonself-originating metabolites). This assay has 190 in-house standards with the majority enrich…