Gali Umschweif
YOU?
Author Swipe
View article: Neurensin-2 is a negative regulator of CB1 receptor
Neurensin-2 is a negative regulator of CB1 receptor Open
Major depressive disorder (MDD) is a leading cause of disability worldwide. Unfortunately, approximately 30 % of MDD patients do not respond to available antidepressants, and characterization of novel molecular mediators of MDD is urgently…
View article: Characterization of Neurensin-2 knockout mice: insights into stress-resilience mechanisms
Characterization of Neurensin-2 knockout mice: insights into stress-resilience mechanisms Open
Major depressive disorder (MDD) affects millions worldwide, yet its pathophysiology remains poorly understood. While some individuals are susceptible to developing depression, others show resilience that protects them from developing MDD. …
View article: Identification of Neurensin-2 as a novel modulator of emotional behavior
Identification of Neurensin-2 as a novel modulator of emotional behavior Open
Among the hallmarks of major depressive disorders (MDD) are molecular, functional, and morphological impairments in the hippocampus. Recent studies suggested a key role for hippocampal GABAergic interneurons both in depression and in the r…
View article: Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants
Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants Open
The delayed behavioral response to chronic antidepressants depends on dynamic changes in the hippocampus. It was suggested that the antidepressant protein p11 and the chromatin remodeling factor SMARCA3 mediate this delayed response by ind…
View article: Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression
Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression Open
The activity of dentate gyrus PV cells plays a major role in the behavioral response to novelty and stress. Activation of the Kv3.1 channel in dentate gyrus PV cells may represent a target for the development of cell-type specific, fast-ac…
View article: Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression
Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression Open
Parvalbumin (PV)-expressing interneurons are important for cognitive and emotional behaviors. These neurons express high level of p11, a protein associated with depression and action of antidepressants. Here we show that either specific de…
View article: HCN2 Channels in Cholinergic Interneurons of Nucleus Accumbens Shell Regulate Depressive Behaviors
HCN2 Channels in Cholinergic Interneurons of Nucleus Accumbens Shell Regulate Depressive Behaviors Open
View article: Heat Acclimation Provides Sustained Improvement in Functional Recovery and Attenuates Apoptosis after Traumatic Brain Injury
Heat Acclimation Provides Sustained Improvement in Functional Recovery and Attenuates Apoptosis after Traumatic Brain Injury Open
Correction to: Journal of Cerebral Blood Flow and Metabolism (2010) 30, 616–627; doi:10.1038/jcbfm.2009.234; published online 11 November 2009. Following the publication of this article, the authors noticed that Dr Umschweif was misspelled…
View article: Molecular programs induced by heat acclimation confer neuroprotection against TBI and hypoxic insults via cross-tolerance mechanisms
Molecular programs induced by heat acclimation confer neuroprotection against TBI and hypoxic insults via cross-tolerance mechanisms Open
Neuroprotection following prolonged exposure to high ambient temperatures (heat acclimation HA) develops via altered molecular programs such as cross-tolerance Heat Acclimation-Neuroprotection Cross-Tolerance (HANCT). The mechanisms underl…