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View article: Factors Influencing Mortality in Patients with Pacemaker/ICD Dysfunction Presenting to Emergency Departments
Factors Influencing Mortality in Patients with Pacemaker/ICD Dysfunction Presenting to Emergency Departments Open
Aim: Management of patients with heart failure and implanted cardioverter defibrillators (ICDs) is as important as ICD placement. Inappropriate shocks and factors affecting mortality are the factors determining management. Appropriate inte…
View article: One Night of Fun, One Lifetime of Effects: MDMA and Sympathomimetic Syndrome
One Night of Fun, One Lifetime of Effects: MDMA and Sympathomimetic Syndrome Open
Sympathomimetic syndromes are rare medical conditions involving complex clinical pictures caused by substances that have a stimulatory effect on the sympathetic nervous system or have similar effects to the sympathetic nervous system. In t…
View article: An Interesting Case of Posterior Reversible Encephalopathy Syndrome
An Interesting Case of Posterior Reversible Encephalopathy Syndrome Open
Posterior Reversible Encephalopathy Syndrome (PRES) is a special type of cerebrovascular disease defined by clinical and imaging findings. The onset of PRES typically includes acute or subacute headaches, visual impairment, seizures, focal…
View article: Intracranial Bleeding in Methanol Intoxication Case
Intracranial Bleeding in Methanol Intoxication Case Open
Methyl alcohol, which is mostly used in the industrial sector, is also widely used in our country to obtain cheap drinks. It is a colorless, volatile liquid with a distinctive odor. Even 8-10 ml of methanol taken into the body from outside…
View article: Streptococcus pneumonia-induced meningoencephalitis presenting as rhinitis and acute stroke!
Streptococcus pneumonia-induced meningoencephalitis presenting as rhinitis and acute stroke! Open
Meningoencephalitis, a potentially fatal condition marked by inflammation of the brain and medulla spinalis, can exhibit a wide range of symptoms. Streptococcus pneumonia, a gram-positive bacterium, is a common bacterial factor for this co…
View article: Falx interhemispheric subdural hematoma in a hypertensive patient with urticaria: A case report
Falx interhemispheric subdural hematoma in a hypertensive patient with urticaria: A case report Open
Falx interhemispheric subdural hematoma (FISH) is a rare subtype of subdural hematoma that occurs between the cerebral hemispheres along with falx cerebri. It represents less than 0.5% of all subdural hematomas and is frequently misdiagnos…
View article: Analysis of echocardiographic characteristics in patients with acute intracerebral hemorrhage
Analysis of echocardiographic characteristics in patients with acute intracerebral hemorrhage Open
Purpose: The aim of this article is to evaluate the effect of basal ganglia hemorrhage on cardiac functions in the acute stage using transthoracic echocardiography. Methods: Based on the data regarding computerize tomography and echocardio…
View article: Clinical Characteristics and Multi-Model Imaging Analysis of Moyamoya Disease: An Observational Study
Clinical Characteristics and Multi-Model Imaging Analysis of Moyamoya Disease: An Observational Study Open
The study was to analyze the clinical features and imaging characteristics of moyamoya disease (MMD) and to explore the significance of multi-model imaging in the diagnosis of MMD. A retrospective analysis of the clinical features, imaging…
View article: Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism <i>via</i> AMPK/SIRT1/PGC-1α pathway in rats
Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism <i>via</i> AMPK/SIRT1/PGC-1α pathway in rats Open
Mitochondria-mediated oxidative stress and apoptosis contribute greatly to early brain injury (EBI) following subarachnoid hemorrhage (SAH). This study hypothesized that activation of melanocortin 1 receptor (MC1R), using BMS-470539, atten…
View article: Peroxisomal Dysfunction Contributes to White Matter Injury Following Subarachnoid Hemorrhage in Rats via Thioredoxin-Interacting Protein-Dependent Manner
Peroxisomal Dysfunction Contributes to White Matter Injury Following Subarachnoid Hemorrhage in Rats via Thioredoxin-Interacting Protein-Dependent Manner Open
Peroxisomal dysfunction induced by SAH reversely exacerbated cerebral WMI following SAH, which was at least partly mediated by TXNIP and GNPAT pathways.
View article: Rh-relaxin-2 Attenuates Degranulation of mast cells by Inhibiting NF-κB through PI3K-AKT/TNFAIP3 Pathway in an Experimental Germinal Matrix Hemorrhage Rat Model
Rh-relaxin-2 Attenuates Degranulation of mast cells by Inhibiting NF-κB through PI3K-AKT/TNFAIP3 Pathway in an Experimental Germinal Matrix Hemorrhage Rat Model Open
Background: Mast cells play an important role in early immune reactions in the brain by inducing degranulation and releasing inflammatory mediators. Our aim of the study is to investigate the effects of rh-relaxin-2 on mast cells and the u…
View article: Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NFκB pathway following asphyxial cardiac arrest in rats
Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NFκB pathway following asphyxial cardiac arrest in rats Open
Background Cardiac arrest survivors suffer from neurological dysfunction including cognitive impairment. Cerebral mast cells, the key regulators of neuroinflammation contribute to neuroinflammation-associated cognitive dysfunction. Mast ce…
View article: Inhibition of PAR-2 Attenuates Neuroinflammation and Improves Short-Term Neurocognitive Functions Via ERK1/2 Signaling Following Asphyxia-Induced Cardiac Arrest in Rats
Inhibition of PAR-2 Attenuates Neuroinflammation and Improves Short-Term Neurocognitive Functions Via ERK1/2 Signaling Following Asphyxia-Induced Cardiac Arrest in Rats Open
Objective: Global cerebral ischemia-induced neuroinflammation causes neurofunctional impairment following cardiac arrest. Previous studies have demonstrated that the activation of protease-activated receptor-2 (PAR-2) contributes to neuroi…
View article: Contribution of Experimental Animal Research Studies to the Emergency Medicine Literature
Contribution of Experimental Animal Research Studies to the Emergency Medicine Literature Open
The aim of this study is to provide a detailed analysis of emergency medicine (EM) research literature to unveil the trends while underlining the importance of experimental research for all territories of science. To this end, the experime…
View article: Inhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of asphyxia induced-cardiac arrest
Inhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of asphyxia induced-cardiac arrest Open
Cognitive deficits are a devastating neurological outcome seen in survivors of cardiac arrest. We previously reported water electrolysis derived 67% hydrogen gas inhalation has some beneficial effects on short-term outcomes in a rat model …
View article: Fsllry-nh2 improves neurological outcome following cardiac arrest in rats
Fsllry-nh2 improves neurological outcome following cardiac arrest in rats Open
Targeting PAR2 may be a novel therapeutic approach in the management of neurological dysfunction after cardiac arrest-associated ischemic injury.