Umut Özcan
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View article: The relationship between inspiratory area under the curve in spirometry and sleep apnea in children
The relationship between inspiratory area under the curve in spirometry and sleep apnea in children Open
View article: PGxDB: an interactive web-platform for pharmacogenomics research
PGxDB: an interactive web-platform for pharmacogenomics research Open
Pharmacogenomics, the study of how an individual's genetic makeup influences their response to medications, is a rapidly evolving field with significant implications for personalized medicine. As researchers and healthcare professionals fa…
View article: Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology
Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology Open
Parkinson disease (PD)-affected brains show consistent endoplasmic reticulum (ER) stress and mitophagic dysfunctions. The mechanisms underlying these perturbations and how they are directly linked remain a matter of questions. XBP1 is a tr…
View article: Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology
Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology Open
Parkinson disease (PD)-affected brains show consistent endoplasmic reticulum (ER) stress and mitophagic dysfunctions. The mechanisms underlying these perturbations and how they are directly linked remain a matter of questions. XBP1 is a tr…
View article: Lipocalin 2 Does Not Play A Role in Celastrol-Mediated Reduction in Food Intake and Body Weight
Lipocalin 2 Does Not Play A Role in Celastrol-Mediated Reduction in Food Intake and Body Weight Open
View article: IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects
IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects Open
View article: Treatment of Obesity and Associated Diseases with Small Molecule Chemical Chaperones
Treatment of Obesity and Associated Diseases with Small Molecule Chemical Chaperones Open
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View article: PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism
PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism Open
Our findings reveal a novel function of PGC-1α as a suppressor of XBP1s function, suggesting that hepatic PGC-1α promotes gluconeogenesis through multiple pathways as a co-activator for HNF4α and FoxO1 and also as a suppressor for anti-glu…
View article: The Modelling and Correlation Procedure for Assessment of Vibration Performance of a Heavy Commercial Truck
The Modelling and Correlation Procedure for Assessment of Vibration Performance of a Heavy Commercial Truck Open
Application of mathematical modelling and numerical methods is a key element of optimum vehicle development process. Upfront CAE (Computer Aided Engineering) simulations of vehicle attributes are required to select designs that meet vehicl…
View article: Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes
Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes Open
View article: A methodology to design multi-axis test rigs for vibration and durability testing using frequency response functions
A methodology to design multi-axis test rigs for vibration and durability testing using frequency response functions Open
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View article: Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction
Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction Open
View article: Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice
Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice Open
View article: XBP1s Is an Anti-lipogenic Protein
XBP1s Is an Anti-lipogenic Protein Open
Endoplasmic reticulum (ER) stress has been shown to contribute to various metabolic diseases, including non-alcoholic fatty liver disease and type 2 diabetes. Reduction of ER stress by treatment with chemical chaperones or overexpression o…
View article: Treatment of Obesity with Celastrol
Treatment of Obesity with Celastrol Open