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View article: A giant basilar artery perforator aneurysm
A giant basilar artery perforator aneurysm Open
Basilar artery perforator aneurysms (BAPA's) are a rare entity. Their natural history and treatment are unclear. We describe the largest BAPA reported thus far in literature in a 64-year-old Caucasian woman. This patient did not present wi…
View article: Sex steroids and markers of micro- and macrovascular damage among women and men from the general population
Sex steroids and markers of micro- and macrovascular damage among women and men from the general population Open
Aims The contribution of sex hormones to micro- and macrovascular damage might differ among women and men. In particular, little is known about the association between sex hormones and small vessel disease. Therefore, we examined the assoc…
View article: Unspecified Strokes: Time Trends, Determinants, and Long-Term Prognosis in the General Population
Unspecified Strokes: Time Trends, Determinants, and Long-Term Prognosis in the General Population Open
Introduction: In the absence of neuroimaging, a stroke is typically labelled as unspecified. While the majority of clinic-based stroke research focuses on hemorrhagic or ischemic stroke, in the general population, a substantial proportion …
View article: Supplementary Material for: Unspecified Strokes: Time Trends, Determinants, and Long-Term Prognosis in the General Population
Supplementary Material for: Unspecified Strokes: Time Trends, Determinants, and Long-Term Prognosis in the General Population Open
Introduction: In the absence of neuroimaging, a stroke is typically labelled as unspecified. While the majority of clinic-based stroke research focuses on hemorrhagic or ischemic stroke, in the general population, a substantial proportion …
View article: Global Brain Perfusion and the Risk of Transient Ischemic Attack and Ischemic Stroke: The Rotterdam Study
Global Brain Perfusion and the Risk of Transient Ischemic Attack and Ischemic Stroke: The Rotterdam Study Open
Background The role of subtle disturbances of brain perfusion in the risk of transient ischemic attack ( TIA) or ischemic stroke remains unknown. We examined the association between global brain perfusion and risk of TIA and ischemic strok…
View article: Clinical interpretation of negative mediated interaction
Clinical interpretation of negative mediated interaction Open
Background Recently, using a counterfactual framework, a causal mediation analysis has been formalized to decompose the total effect of a time-fixed exposure on an outcome into four components that can be loosely defined as being component…
View article: Lifetime risk of common neurological diseases in the elderly population
Lifetime risk of common neurological diseases in the elderly population Open
Objective To quantify the burden of common neurological disease in older adults in terms of lifetime risks, including their co-occurrence and preventive potential, within a competing risk framework. Methods Within the prospective populatio…
View article: P4449Sex steroids, sex hormone-binding globulin and markers of micro- and macrovascular damage
P4449Sex steroids, sex hormone-binding globulin and markers of micro- and macrovascular damage Open
Risk factors and prevention -Epidemiology 895group which showed family history of HU had significantly higher SUA levels compared with the group which did not (7.9±0.9 vs. 5.8±1.3mg/dL, p<0.001).In univariate analysis, family history of HU…
View article: Association of Retinal Neurodegeneration on Optical Coherence Tomography With Dementia
Association of Retinal Neurodegeneration on Optical Coherence Tomography With Dementia Open
Thinner RNFL is associated with an increased risk of dementia, including Alzheimer disease, suggesting that retinal neurodegeneration may serve as a preclinical biomarker for dementia.
View article: Thinner retinal layers are associated with changes in the visual pathway: A population‐based study
Thinner retinal layers are associated with changes in the visual pathway: A population‐based study Open
Increasing evidence shows that thinner retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), assessed on optical coherence tomography (OCT), are reflecting global brain atrophy. Yet, little is known on the relation of these layer…
View article: The Retina as a Biomarker for Vascular and Neurodegenerative Brain Diseases
The Retina as a Biomarker for Vascular and Neurodegenerative Brain Diseases Open
Over the years, the research field investigating the eye-brain connection has increased steeply, and researchers have begun to recognize the potential to use retinal structures as biomarkers for brain diseases. Given that retinal structure…
View article: The retinal microcirculation in migraine: The Rotterdam Study
The retinal microcirculation in migraine: The Rotterdam Study Open
Background To explore the role of microvascular pathology in migraine, we investigated the association between migraine and retinal microvascular damage. Methods We included 3270 participants (age ≥ 45 years, 63% women) from the population…
View article: Vitamin D and retinal microvascular damage
Vitamin D and retinal microvascular damage Open
Vitamin D has been linked to various cardiovascular risk factors including indices of large-vessel disease. However, it remains unclear whether vitamin D is also associated with microvascular damage. In a community-dwelling population, we …
View article: N-Terminal Pro-B–Type Natriuretic Peptide Is Related to Retinal Microvascular Damage
N-Terminal Pro-B–Type Natriuretic Peptide Is Related to Retinal Microvascular Damage Open
Objective— N-terminal pro-B–type natriuretic peptide (NT-proBNP) is a marker of cardiac dysfunction and has been linked to various indices of large vessel disease. However, it remains unclear whether NT-proBNP also relates to microvascular…
View article: Retinal Microvascular Calibers Are Associated With Enlarged Perivascular Spaces in the Brain
Retinal Microvascular Calibers Are Associated With Enlarged Perivascular Spaces in the Brain Open
Background and Purpose— Perivascular enlargement in the brain is a putative imaging marker for microvascular brain damage, but this link has not yet been confirmed using direct in vivo visualization of small vessels. We investigated the re…