Tomoki Uno
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View article: Prevalence and Impact of Social Frailty in Patients with Chronic Obstructive Pulmonary Disease
Prevalence and Impact of Social Frailty in Patients with Chronic Obstructive Pulmonary Disease Open
The prevalence of social frailty is 36%; however, social frailty has a marked clinical impact in patients with COPD.
View article: Long-term follow-up of production of IgM and IgG antibodies against SARS-CoV-2 among patients with COVID-19
Long-term follow-up of production of IgM and IgG antibodies against SARS-CoV-2 among patients with COVID-19 Open
The patients diagnosed with coronavirus disease 2019 (COVID-19) produce IgM and IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the frequency and duration of antibody production still need to b…
View article: Fetal Lung Cells Transfer Improves Emphysematous Change in a Mouse Model of Neutrophil Elastase-Induced Lung Emphysema
Fetal Lung Cells Transfer Improves Emphysematous Change in a Mouse Model of Neutrophil Elastase-Induced Lung Emphysema Open
Recently, several studies for lung regeneration have been reported. However, regenerating the lung tissue by the transfer of any cells directly to the lung has been hardly successful. The aim of this study was to evaluate the effect of fet…
View article: Characteristics of and reasons for patients with chronicobstructive pulmonary disease to continue smoking, quitsmoking, and switch to heated tobacco products
Characteristics of and reasons for patients with chronicobstructive pulmonary disease to continue smoking, quitsmoking, and switch to heated tobacco products Open
Patients with COPD who continue smoking tended to have low appetite as well as smoking behaviors that are not guaranteed to be safe. Physicians should provide appropriate guidance to these patients on smoking cessation.
View article: Comprehensive Gene Expression Signature Using RNA-Seq in Airways of Mouse Model of Severe Asthma with Fungal Sensitization
Comprehensive Gene Expression Signature Using RNA-Seq in Airways of Mouse Model of Severe Asthma with Fungal Sensitization Open
Introduction: Inhalation of fungal allergens induces airway epithelial damage following airway inflammation and excessive mucus secretion, which can lead to severe asthma with fungal sensitization (SAFS). Comprehensive gene expression anal…
View article: β<sub>2</sub>‐adrenoceptor agonist inhalation induced paroxysmal atrial fibrillation and tachycardia in a patient with severe bronchial asthma
β<sub>2</sub>‐adrenoceptor agonist inhalation induced paroxysmal atrial fibrillation and tachycardia in a patient with severe bronchial asthma Open
To the Editor: In 2019, approximately 235 million patients were diagnosed with bronchial asthma globally.1 The standard treatment for bronchial asthma is the inhalation of β2-adrenoceptor (AR) agonists, besides corticosteroids. The effects…
View article: Utility of SpO2/FiO2 ratio for acute hypoxemic respiratory failure with bilateral opacities in the ICU
Utility of SpO2/FiO2 ratio for acute hypoxemic respiratory failure with bilateral opacities in the ICU Open
Acute hypoxemic respiratory failure (AHRF) with bilateral opacities causes fatalities in the intensive care unit (ICU). It is often difficult to identify the causes of AHRF at the time of admission. The SpO 2 to FiO 2 (S/F) ratio has been …
View article: Fatal rupture of pulmonary artery pseudoaneurysm after thoracic radiation therapy against lung squamous cell carcinoma: A case report and literature review
Fatal rupture of pulmonary artery pseudoaneurysm after thoracic radiation therapy against lung squamous cell carcinoma: A case report and literature review Open
Pulmonary artery pseudoaneurysm is a rare but fatal condition. It has been associated with lung cancer, abscesses, and radiation therapy. Identification in patients with hemoptysis is critical, and timely interventional therapy is warrante…
View article: <p>The Relationship Between the “Adherence Starts with Knowledge-20” Questionnaire and Clinical Factors in Patients with COPD: A Multi-Center, Cross-Sectional Study</p>
The Relationship Between the “Adherence Starts with Knowledge-20” Questionnaire and Clinical Factors in Patients with COPD: A Multi-Center, Cross-Sectional Study Open
The ASK-20 scores in patients with COPD were significantly associated with CAT and HADS scores. In Japan, Respimat was prescribed to younger patients and patients with lower CAT scores. The ASK-20, a simple evaluation method, is useful for…
View article: Correlation of Arterial CO2 and Respiratory Impedance Values among Subjects with COPD
Correlation of Arterial CO2 and Respiratory Impedance Values among Subjects with COPD Open
Chronic obstructive pulmonary disease (COPD) is a respiratory illness characterized by airflow limitation and chronic respiratory symptoms with a global prevalence estimated to be more than 10% in 2010 and still on the rise. Furthermore, h…
View article: Fatal rupture of pulmonary artery pseudoaneurysm after thoracic radiation therapy against lung squamous cell carcinoma: a case report and literature review
Fatal rupture of pulmonary artery pseudoaneurysm after thoracic radiation therapy against lung squamous cell carcinoma: a case report and literature review Open
Rupture of pulmonary artery pseudoaneurysm (PAP) can result in life-threatening hemoptysis. A 65-year-old male was diagnosed with PAP based on chest contrasted computer tomography (CT). He coughed up massive amounts of blood and could not …
View article: Inhibition of Virus-Induced Cytokine Production from Airway Epithelial Cells by the Late Addition of Budesonide
Inhibition of Virus-Induced Cytokine Production from Airway Epithelial Cells by the Late Addition of Budesonide Open
Background and objectives: Viral infection is the main cause of asthma and COPD (chronic obstructive pulmonary disease) exacerbation and accumulate inflammatory cells to airway tissue. We have reported poly I:C, a mimic product of the viru…
View article: Efficacy of Mepolizumab for Long-term Treatment in Patients with Severe Asthma
Efficacy of Mepolizumab for Long-term Treatment in Patients with Severe Asthma Open
Mepolizumab is a monoclonal antibody against interleukin-5 used for the treatment of severe asthma. The effect of long-term mepolizumab administration and its persistence in clinical practice is poorly understood. Thus, this study aimed to…
View article: Combination treatment of short-course systemic corticosteroid and favipiravir in a successfully treated case of critically ill COVID-19 pneumonia with COPD
Combination treatment of short-course systemic corticosteroid and favipiravir in a successfully treated case of critically ill COVID-19 pneumonia with COPD Open
Use of systemic corticosteroids for the treatment for coronavirus disease 2019 (COVID-19) among chronic obstructive pulmonary disease (COPD) patients is not well described. A 58-year-old man with fever and progressive dyspnea was admitted …
View article: Inhibitory Effects of <i>Chlorella</i> Extract on Airway Hyperresponsiveness and Airway Remodeling in a Murine Model of Asthma
Inhibitory Effects of <i>Chlorella</i> Extract on Airway Hyperresponsiveness and Airway Remodeling in a Murine Model of Asthma Open
Chlorella extract （CE） has been shown to induce production of T helper-1 cytokines, and regulate serum IgE levels in animal models of asthma. We aimed to evaluate whether CE could inhibit ovalbumin （OVA）-induced airway hyperresponsiveness …
View article: Predicting future risk of exacerbations in Japanese patients with adult asthma: A prospective 1-year follow up study
Predicting future risk of exacerbations in Japanese patients with adult asthma: A prospective 1-year follow up study Open
This study implicated that exacerbations during the preceding year reliably predict future risk of exacerbations in Japanese patients with asthma.