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View article: Mitochondrial fission enhances <scp>IL</scp>‐6‐induced metastatic potential in ovarian cancer via <scp>ERK1</scp>/2 activation
Mitochondrial fission enhances <span>IL</span>‐6‐induced metastatic potential in ovarian cancer via <span>ERK1</span>/2 activation Open
Ovarian cancer is a lethal gynecologic cancer mostly diagnosed in an advanced stage with an accumulation of ascites. Interleukin‐6 (IL‐6), a pro‐inflammatory cytokine is highly elevated in malignant ascites and plays a pleiotropic role in …
View article: Wnt/β-Catenin Inhibition by CWP232291 as a Novel Therapeutic Strategy in Ovarian Cancer
Wnt/β-Catenin Inhibition by CWP232291 as a Novel Therapeutic Strategy in Ovarian Cancer Open
The poor prognosis of ovarian cancer patients mainly results from a lack of early diagnosis approaches and a high rate of relapse. Only a very modest improvement has been made in ovarian cancer patient survival with traditional treatments.…
View article: Computational modeling of malignant ascites reveals CCL5–SDC4 interaction in the immune microenvironment of ovarian cancer
Computational modeling of malignant ascites reveals CCL5–SDC4 interaction in the immune microenvironment of ovarian cancer Open
Fluid accumulation in the abdominal cavity is commonly found in advanced‐stage ovarian cancer patients, which creates a specialized tumor microenvironment for cancer progression. Using single‐cell RNA sequencing (scRNA‐seq) of ascites cell…
View article: Association of ALDH1A1-NEK-2 axis in cisplatin resistance in ovarian cancer cells
Association of ALDH1A1-NEK-2 axis in cisplatin resistance in ovarian cancer cells Open
Development of acquired resistance to cisplatin (CDDP) is a major obstacle in the treatment of ovarian cancer patients. According to the cancer stem cell (CSC) hypothesis, the recurrence and chemoresistance are presumed to be linked to can…
View article: Decursin and Decursinol Angelate Suppress Adipogenesis through Activation of β-catenin Signaling Pathway in Human Visceral Adipose-Derived Stem Cells
Decursin and Decursinol Angelate Suppress Adipogenesis through Activation of β-catenin Signaling Pathway in Human Visceral Adipose-Derived Stem Cells Open
Visceral adiposity is closely associated with metabolic disorders and cardiovascular diseases. Angelica gigas Nakai (AGN) has been reported to possess anti-obesity effects and higher amounts of coumarin compounds are present in AGN. Howeve…
View article: Abstract 124: Evaluating heterogeneity of tumor microenvironment using single cell RNA sequencing
Abstract 124: Evaluating heterogeneity of tumor microenvironment using single cell RNA sequencing Open
Tumor microenvironment interacts with cancer cells, causing tumor progression. Tumor microenvironment consists of cellular and acelluar components. We investigated cellular components of tumor microenvironment and heterogeneity of ovarian …
View article: Development of Web-Based Nomograms to Predict Treatment Response and Prognosis of Epithelial Ovarian Cancer
Development of Web-Based Nomograms to Predict Treatment Response and Prognosis of Epithelial Ovarian Cancer Open
We successfully developed nomograms predicting treatment response and prognosis of patients with EOC. These nomograms are expected to be useful in clinical practice and designing clinical trials.