Upasna Varma
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View article: Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues
Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues Open
Diabetic heart disease is highly prevalent and is associated with the early development of impaired diastolic relaxation. The mechanisms of diabetic heart disease are poorly understood and it is a condition for which there are no targeted …
View article: Methods for detection of cardiac glycogen-autophagy
Methods for detection of cardiac glycogen-autophagy Open
Glycogen-autophagy ('glycophagy') is a selective autophagy process involved in delivering glycogen to the lysosome for bulk degradation. Glycophagy protein intermediaries include STBD1 as a glycogen tagging receptor, delivering the glycoge…
View article: Methods for detection of cardiac glycogen-autophagy
Methods for detection of cardiac glycogen-autophagy Open
Glycogen-autophagy (‘glycophagy’) is a selective autophagy process involved in delivering glycogen to the lysosome for bulk degradation. Glycophagy protein intermediaries include STBD1 as a glycogen tagging receptor, delivering the glycoge…
View article: Myocardial glycophagy flux dysregulation and glycogen accumulation characterize diabetic cardiomyopathy
Myocardial glycophagy flux dysregulation and glycogen accumulation characterize diabetic cardiomyopathy Open
Diabetic heart disease morbidity and mortality is escalating. No specific therapeutics exist and mechanistic understanding of diabetic cardiomyopathy etiology is lacking. While lipid accumulation is a recognized cardiomyocyte phenotype of …
View article: Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy
Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy Open
Autophagy is an essential cellular process involving degradation of superfluous or defective macromolecules and organelles as a form of homeostatic recycling. Initially proposed to be a "bulk" degradation pathway, a more nuanced appreciati…
View article: Evolving Concepts of Glycogen-Selective Autophagy
Evolving Concepts of Glycogen-Selective Autophagy Open
Macro-autophagy is an essential cellular process involved in degradation of aberrant organelles and proteins. Initially proposed to be a ‘bulk’ degradation pathway, a more nuanced appreciation of selective autophagy pathways ha…
View article: Protective role of the Atg8 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease
Protective role of the Atg8 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease Open
Summary Diabetic heart disease is highly prevalent and characterized by diastolic dysfunction. The mechanisms of diabetic heart disease are poorly understood and no targeted therapies are available. Here we show that the diabetic myocardiu…