Uria Shani
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View article: The effectiveness of second- and-third-line biologics in perianal Crohn’s disease—a multicenter propensity score-matched study
The effectiveness of second- and-third-line biologics in perianal Crohn’s disease—a multicenter propensity score-matched study Open
Background and Aims Anti-tumor necrosis factor-α inhibitors (anti-TNFs) are the established treatment for perianal Crohn’s disease (pCD), but relapse and non-response are common. Data on second- and third-line biologics are limited. We pre…
Mortality in Antinuclear Antibody-Positive Patients with and Without Rheumatologic Immune-Related Disorders: A Large-Scale Population-Based Study Open
Background & Objectives: To explore the potential association between positive ANA serology and all-cause mortality in a large cohort of patients, including those with and without rheumatological conditions and other immune-related disease…
Mortality in Antinuclear Antibody-Positive Patients with and Without Rheumatologic Immune-Related Disorders: A Large-Scale Population-Based Study Open
Background & Objectives: To explore the potential association between positive ANA serology and all-cause mortality in a large cohort of patients, including those with and without rheumatological conditions and other immune-related disease…
Assessing Generative Pretrained Transformers (GPT) in Clinical Decision-Making: Comparative Analysis of GPT-3.5 and GPT-4 Open
Background Artificial intelligence, particularly chatbot systems, is becoming an instrumental tool in health care, aiding clinical decision-making and patient engagement. Objective This study aims to analyze the performance of ChatGPT-3.5 …
Short-term effectiveness and safety of ustekinumab and vedolizumab in elderly and non-elderly patients with Crohn’s disease: a comparative study Open
Background: Inflammatory bowel disease (IBD) presents unique challenges in elderly patients due to comorbidities and treatment-related risks. Objectives: This study evaluates ustekinumab (UST) and vedolizumab (VDZ) efficacy and safety in e…
P834 Choosing wisely: Ustekinumab in Elderly Crohn’s Patients – A Comparative Study Open
Background The burden of Inflammatory Bowel Disease (IBD) in elderly patients derives from background comorbidities and the elevated risk associated with immunosuppressive treatments. In the present study, we aimed to assess the efficacy a…
The association between psoriasis, psoriasis severity, and inflammatory bowel disease: a population-based analysis Open
Background: The skin–gut axis, characterized by bidirectional communication between the skin and gut, plays a crucial role in the pathogenesis of psoriasis and inflammatory bowel diseases (IBD). Objectives: We aimed to explore the associat…
Assessing Generative Pretrained Transformers (GPT) in Clinical Decision-Making: Comparative Analysis of GPT-3.5 and GPT-4 (Preprint) Open
BACKGROUND Artificial intelligence, particularly chatbot systems, is becoming an instrumental tool in health care, aiding clinical decision-making and patient engagement. OBJECTIVE This study aims to analyze the performance of ChatGPT-3.5 …
View article: Expectant management of tubal pregnancies with human chorionic gonadotropin up to 2000 mIU/mL
Expectant management of tubal pregnancies with human chorionic gonadotropin up to 2000 mIU/mL Open
Objective To describe outcomes of expectant management (EM) versus methotrexate (MTX) treatment in tubal pregnancies with pretreatment human chorionic gonadotropin (hCG) less than 2000 mIU/mL. Methods This retrospective cohort from two ter…
POS1213 RISK OF ATHEROSCLEROSIS-RELATED DISEASES IN ADULTS WITH POLYMYOSITIS AND DERMATOMYOSITIS: A LARGE SCALE POPULATION-BASED STUDY Open
Background Select systemic autoimmune diseases show a predilection to Atherosclerotic and Cardiovascular Disease (ASCVD) largely attributed to proinflammatory cytokines supporting the role of the inflammatory hypothesis in endothelial dysf…
P806 Perianal Crohn’s Disease (pCD): The outcome of 2nd line and 3rd line biologics in perianal Crohn’s disease Open
Background Treating perianal Crohn’s disease (pCD) is challenging with at least 60% of the patients not responding or relapsing after a year of 1st line biological therapy. Effectiveness data on 2nd and 3rd line in pCD is still quite limit…
Outcome of inflammatory bowel disease patients with prior malignancy Open
Anti-TNF treatment may be associated with an increased risk of NMSC recurrence. This underscores the importance of rigorous dermatological follow up in IBD patients with previous NMSC treated with anti-TNFs.
View article: Inflammatory Bowel Diseases Are Associated with Polymyositis and Dermatomyositis—A Retrospective Cohort Analysis
Inflammatory Bowel Diseases Are Associated with Polymyositis and Dermatomyositis—A Retrospective Cohort Analysis Open
Background and Objectives: Polymyositis and dermatomyositis (PM/DM) are classified as polygenic autoimmune diseases, whereas inflammatory bowel disease (IBD) is considered a polygenic autoinflammatory disease. In the literature, several ca…
P515 Inflammatory bowel disease and malignancy – the outcome of patients with malignancy diagnosed before IBD diagnosis or IBD-targeted therapy Open
Background The treatment strategy in IBD patients with previous malignancy is not well defined, and the available literature is scarce.The main aim of this study was to describe the outcome of IBD patients with previous malignancy or befor…
OP04.02: Prediction model for obstetric anal sphincter injuries (OASI) Open
OASI are the most common cause of anal incontinence in women. Developing a prediction model for OASI may aid in primary prevention. Retrospective cohort study of women with a singleton vertex vaginal delivery between 2011-2018 from the She…
OP04.01: Modifiable risk factors for obstetric anal sphincter injury (OASI) in primiparous women Open
To identify modifiable risk factors for OASI in primiparous women. Retrospective cohort study of primiparous women with a singleton vaginal delivery between 2011-2018 from the Sheba Medical Center Delivery Registry, and validation with pro…