Uriel López-Sánchez
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View article: Precision defect integrated graphene as reliable support membrane for high-resolution cryo-transmission electron microscopy
Precision defect integrated graphene as reliable support membrane for high-resolution cryo-transmission electron microscopy Open
View article: Author Correction: Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT3 receptors
Author Correction: Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT3 receptors Open
View article: Ligand binding initiates single-molecule integrin conformational activation
Ligand binding initiates single-molecule integrin conformational activation Open
View article: Structural Determinants for Activity of the Antidepressant Vortioxetine at Human and Rodent 5-HT<sub>3</sub>receptors
Structural Determinants for Activity of the Antidepressant Vortioxetine at Human and Rodent 5-HT<sub>3</sub>receptors Open
Summary Vortioxetine (VTX) is a recent antidepressant that targets a variety of serotonin receptors. We investigate the drug’s molecular mechanism of operation at serotonin 5-HT 3 receptors (5-HT 3 R), which features two mysterious propert…
View article: Precision Defect Integrated Graphene as Reliable Support Membrane for High-Resolution Cryo-Transmission Electron Microscopy
Precision Defect Integrated Graphene as Reliable Support Membrane for High-Resolution Cryo-Transmission Electron Microscopy Open
View article: Superiority of the Triple-Acting 5-HT<sub>6</sub>R/5-HT<sub>3</sub>R Antagonist and MAO-B Reversible Inhibitor <b>PZ-1922</b> over 5-HT<sub>6</sub>R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats
Superiority of the Triple-Acting 5-HT<sub>6</sub>R/5-HT<sub>3</sub>R Antagonist and MAO-B Reversible Inhibitor <b>PZ-1922</b> over 5-HT<sub>6</sub>R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats Open
The multifactorial origin and neurochemistry of Alzheimer's disease (AD) call for the development of multitarget treatment strategies. We report a first-in-class triple acting compound that targets serotonin type 6 and 3 receptors (5-HT-Rs…
View article: Role of surfactants in electron cryo-microscopy film preparation
Role of surfactants in electron cryo-microscopy film preparation Open
View article: Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM Open
View article: Phosphate Transporter Profiles in Murine and Human Thymi Identify Thymocytes at Distinct Stages of Differentiation
Phosphate Transporter Profiles in Murine and Human Thymi Identify Thymocytes at Distinct Stages of Differentiation Open
Thymocyte differentiation is dependent on the availability and transport of metabolites in the thymus niche. As expression of metabolite transporters is a rate-limiting step in nutrient utilization, cell surface transporter levels generall…
View article: Author Index
Author Index Open
View article: Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis
Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis Open
View article: Characterization of XPR1/SLC53A1 variants located outside of the SPX domain in patients with primary familial brain calcification
Characterization of XPR1/SLC53A1 variants located outside of the SPX domain in patients with primary familial brain calcification Open
View article: XPR1 mutations are a rare cause of primary familial brain calcification
XPR1 mutations are a rare cause of primary familial brain calcification Open
View article: Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export
Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export Open