Ursula Edman
YOU?
Author Swipe
View article: Anti-CD19/CD20 bispecific antibody with dual Fc domains mediates enhanced effector functions and durable depletion of memory B cells in vivo
Anti-CD19/CD20 bispecific antibody with dual Fc domains mediates enhanced effector functions and durable depletion of memory B cells in vivo Open
Recent clinical studies suggest that more potent B cell depleting therapies and targeting more than one B cell antigen may result in improved clinical responses in autoimmune diseases and hematological malignancies. Here we describe an ant…
View article: SUPERDIMERIC ANTIBODY-LIKE MOLECULE WITH DUAL FC DOMAINS PROVIDES POTENT B CELL DEPLETION WITH MINIMAL CYTOKINE INDUCTION VIA TARGETING OF CD19, CD20 AND FC GAMMA RECEPTORS
SUPERDIMERIC ANTIBODY-LIKE MOLECULE WITH DUAL FC DOMAINS PROVIDES POTENT B CELL DEPLETION WITH MINIMAL CYTOKINE INDUCTION VIA TARGETING OF CD19, CD20 AND FC GAMMA RECEPTORS Open
PV265 / #821 Poster Topic: AS24 - SLE-Treatment Background/Purpose Potent tissue B cell depletion using CD19-targeting CAR-T cells or T cell engagers in patients with autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Rheum…
View article: Topologically engineered antibodies and Fc-fusion proteins: a new class of multifunctional therapeutic candidates for SARS-CoV-2, cancer, and other disease
Topologically engineered antibodies and Fc-fusion proteins: a new class of multifunctional therapeutic candidates for SARS-CoV-2, cancer, and other disease Open
The ability of antibodies and Fc-fusion proteins to bind multiple targets cooperatively is limited by their topology. Here we describe our discovery that ACE2 Fc-fusion proteins spontaneously cross-dimerize, forming topologically distinct …