Uwe Reuter
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View article: Sex-related disparities in migraine recognition and management: insights from a tertiary headache center cohort
Sex-related disparities in migraine recognition and management: insights from a tertiary headache center cohort Open
Background Migraine is a highly prevalent and disabling neurological disorder that is often underdiagnosed and undertreated, particularly in early stages of care. Sex-related factors may contribute to this gap. This study investigates sex-…
View article: Efficacy and safety of kinetic oscillation stimulation in the nasal cavity for the treatment of acute migraine attacks: A randomized, placebo-controlled, double-blind investigation
Efficacy and safety of kinetic oscillation stimulation in the nasal cavity for the treatment of acute migraine attacks: A randomized, placebo-controlled, double-blind investigation Open
Background Migraine attacks present a problem for patients who are unable to benefit from drug treatment. The Chordate System S020 delivers kinetic oscillation to the nasal mucosa, which is supposed to modulate the parasympathetic outflow …
View article: Sex hormone profiles in men with migraine: a cross-sectional, matched cohort study
Sex hormone profiles in men with migraine: a cross-sectional, matched cohort study Open
Objective Sex hormones play a key role in migraine pathophysiology, yet their impact in men remains unclear. This study investigates sex hormone profiles and their potential relationship with Calcitonin Gene-Related Peptide (CGRP) in men w…
View article: Changes in brainstem habituation during <scp>onabotulinumtoxinA</scp> treatment in chronic migraine: A prospective case–control study
Changes in brainstem habituation during <span>onabotulinumtoxinA</span> treatment in chronic migraine: A prospective case–control study Open
Objectives/Background Chronic migraine is a debilitating neurological disorder characterized by central sensitization and impaired brainstem habituation. OnabotulinumtoxinA is an established prophylactic treatment for chronic migraine, yet…
View article: Characteristics of patients with cluster headache presenting to a tertiary headache center: A cross-sectional study
Characteristics of patients with cluster headache presenting to a tertiary headache center: A cross-sectional study Open
Aim Cluster headache (CH) is often underdiagnosed and improperly treated. We explored the characteristics of CH patients referred to our tertiary headache center and compared them to patients with migraine and tension-type headache (TTH). …
View article: Comorbidities as risk factors for migraine onset: A systematic review and three‐level meta‐analysis
Comorbidities as risk factors for migraine onset: A systematic review and three‐level meta‐analysis Open
Introduction Migraine is a debilitating neurological disease with a multifaceted pathophysiology. Pre‐existing comorbidities may influence the risk of developing migraine. This review and meta‐analysis aim to present a comprehensive overvi…
View article: Early Improvements With Atogepant for the Preventive Treatment of Migraine
Early Improvements With Atogepant for the Preventive Treatment of Migraine Open
This study provides Class II evidence that atogepant 60 mg QD reduces migraine frequency and improves functional outcomes within 4 weeks of initiation in patients with EM and patients with CM.
View article: Online survey on barriers and drivers to flu vaccination among staff at a German university hospital during the Covid-19 pandemic 2022 (flu-vaccination motive study)
Online survey on barriers and drivers to flu vaccination among staff at a German university hospital during the Covid-19 pandemic 2022 (flu-vaccination motive study) Open
Introduction: The success of flu vaccination depends primarily on the willingness of health care workers (HCWs) to be vaccinated. To identify barriers and drivers to vaccination, an online survey among employees and students of a universit…
View article: Efficacy of eptinezumab in non-responders to subcutaneous monoclonal antibodies against CGRP and the CGRP receptor: A retrospective cohort study
Efficacy of eptinezumab in non-responders to subcutaneous monoclonal antibodies against CGRP and the CGRP receptor: A retrospective cohort study Open
Background Migraine patients unresponsive to calcitonin gene-related peptide (CGRP)(-receptor, -R) monoclonal antibodies (mAbs) may benefit from switching between CGRP(-R) mAbs. However, some patients do not tolerate or respond to any subc…
View article: Erenumab versus topiramate: migraine‐related disability, impact and health‐related quality of life
Erenumab versus topiramate: migraine‐related disability, impact and health‐related quality of life Open
Background and purpose HER‐MES was the first head‐to‐head study of erenumab against topiramate (standard of care). This post hoc analysis of the HER‐MES study evaluated the effect of erenumab versus topiramate on patient‐reported outcomes …
View article: European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention - part 4: propranolol
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention - part 4: propranolol Open
Objective The aim of this paper is to critically re-appraise the published trials assessing propranolol for migraine prophylaxis. Methods We report methods and results following the Preferred Reporting Items for Systematic Reviews (PRISMA)…
View article: Translation of Multidimensional Health Locus of Control Scales, Form C in Patients with Headache
Translation of Multidimensional Health Locus of Control Scales, Form C in Patients with Headache Open
The MHLC-C is a condition-specific instrument measuring the internal and external loci of control beliefs, adaptable to various health conditions. Translated into Swedish and Chinese, this study aims to translate the MHLC-C into German usi…
View article: Prevalence and characteristics of rapid eye movement sleep behaviour disorder in adults with migraine: a cross‐sectional screening study
Prevalence and characteristics of rapid eye movement sleep behaviour disorder in adults with migraine: a cross‐sectional screening study Open
Background and purpose Migraine and sleep disorders share a bidirectional relationship, but little is known about the specific association between migraine and rapid eye movement (REM) sleep behaviour disorder (RBD). The aim was to assess …
View article: Therapeutic patterns and migraine disease burden in switchers of CGRP-targeted monoclonal antibodies – insights from the German NeuroTransData registry
Therapeutic patterns and migraine disease burden in switchers of CGRP-targeted monoclonal antibodies – insights from the German NeuroTransData registry Open
Background Monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway have shown good efficacy in migraine prophylaxis. However, a subset of patients does not respond to the first mAb treatment and switches a…
View article: Alice in Wonderland Syndrome (AIWS): prevalence and characteristics in adults with migraine
Alice in Wonderland Syndrome (AIWS): prevalence and characteristics in adults with migraine Open
Objective Alice in Wonderland Syndrome (AIWS) is a sensory disorder characterized by a distorted somatosensory and/or visual perception. Additionally, distortion of time perception and symptoms of derealization/depersonalization may occur.…
View article: Discrete state-dependent profiles of increased CX3CL1 in cerebrospinal fluid and serum t-Tau elevations in migraine: results from a cross-sectional case-control study
Discrete state-dependent profiles of increased CX3CL1 in cerebrospinal fluid and serum t-Tau elevations in migraine: results from a cross-sectional case-control study Open
Background & Objectives: T o date, migraine is diagnosed exclusively based on clinical criteria, but fluid biomarkers are desirable to gain insight into pathophysiological processes and inform clinical management. We investigated the state…
View article: Rethinking headache as a global public health case model for reaching the SDG 3 HEALTH by 2030
Rethinking headache as a global public health case model for reaching the SDG 3 HEALTH by 2030 Open
The 2030 Agenda for Sustainable Development sets out, through 17 Sustainable Development Goals (SDGs), a path for the prosperity of people and the planet. SDG 3 in particular aims to ensure healthy lives and promote well-being for all at a…
View article: European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 2: flunarizine
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention—part 2: flunarizine Open
Objective Novel disease-specific and mechanism-based treatments sharing good evidence of efficacy for migraine have been recently marketed. However, reimbursement by insurers depends on treatment failure with classic anti-migraine drugs. I…