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View article: Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells
Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells Open
Bone healing is a multifaceted scenario with tightly orchestrated sequences that decide upon successful bone fracture healing or nonunion. In this context, the immune system, particularly the impact of macrophages on mesenchymal stromal ce…
View article: Phenotypic alterations in articulating joint cells: Role of mechanically loaded MSC secretome
Phenotypic alterations in articulating joint cells: Role of mechanically loaded MSC secretome Open
Improvements in the treatment of cartilage require insights into the secretory profile of mesenchymal stem cells (MSCs). Apart from their differentiation potential, MSCs secrete a multitude of molecules with therapeutic properties that ben…
View article: Identification of circulating miRNAs as fracture-related biomarkers
Identification of circulating miRNAs as fracture-related biomarkers Open
Fracture non-unions affect many patients worldwide, however, known risk factors alone do not predict individual risk. The identification of novel biomarkers is crucial for early diagnosis and timely patient treatment. This study focused on…
View article: Venous injection of a triphasic calcium-based implant in a sheep model of pulmonary embolism demonstrates minimal acute systemic effects
Venous injection of a triphasic calcium-based implant in a sheep model of pulmonary embolism demonstrates minimal acute systemic effects Open
Purpose Implant leakage is the most common complication of vertebral augmentation. Alternative injectable materials must demonstrate intravascular safety comparable to or better than polymethyl methacrylate (PMMA). This study assessed the …
View article: In Vitro Evaluation of a Nanoparticle-Based mRNA Delivery System for Cells in the Joint
In Vitro Evaluation of a Nanoparticle-Based mRNA Delivery System for Cells in the Joint Open
Biodegradable and bioresponsive polymer-based nanoparticles (NPs) can be used for oligonucleotide delivery, making them a promising candidate for mRNA-based therapeutics. In this study, we evaluated and optimized the efficiency of a cation…
View article: Differential Regulation of circRNA, miRNA, and piRNA during Early Osteogenic and Chondrogenic Differentiation of Human Mesenchymal Stromal Cells
Differential Regulation of circRNA, miRNA, and piRNA during Early Osteogenic and Chondrogenic Differentiation of Human Mesenchymal Stromal Cells Open
The goal of the present study is to identify the differential expression of circular RNA (circRNA), miRNA, and piwi-interacting RNA (piRNA) after lineage commitment towards osteo- and chondrogenesis of human bone marrow mesenchymal stromal…
View article: Mesenchymal Stem Cell Homing Into Intervertebral Discs Enhances the Tie2-positive Progenitor Cell Population, Prevents Cell Death, and Induces a Proliferative Response
Mesenchymal Stem Cell Homing Into Intervertebral Discs Enhances the Tie2-positive Progenitor Cell Population, Prevents Cell Death, and Induces a Proliferative Response Open
Study Design. Experimental study with human mesenchymal stem cells (MSCs) and intervertebral disc (IVD) tissue samples. Objective. This study aimed to characterize the effect of MSC homing on the Tie2-positive IVD progenitor cell populatio…
View article: Phenotypic Characterization of Bone Marrow Mononuclear Cells and Derived Stromal Cell Populations from Human Iliac Crest, Vertebral Body and Femoral Head
Phenotypic Characterization of Bone Marrow Mononuclear Cells and Derived Stromal Cell Populations from Human Iliac Crest, Vertebral Body and Femoral Head Open
(1) In vitro, bone marrow-derived stromal cells (BMSCs) demonstrate inter-donor phenotypic variability, which presents challenges for the development of regenerative therapies. Here, we investigated whether the frequency of putative BMSC s…
View article: Shear and Dynamic Compression Modulates the Inflammatory Phenotype of Human Monocytes in vitro
Shear and Dynamic Compression Modulates the Inflammatory Phenotype of Human Monocytes in vitro Open
Monocytes and their derived macrophages are found at the site of remodeling tissue, such as fracture hematoma, that is exposed to mechanical forces and have been previously implicated in the reparative response. However, the mechanorespons…
View article: Isolation of high‐quality RNA from intervertebral disc tissue via pronase predigestion and tissue pulverization
Isolation of high‐quality RNA from intervertebral disc tissue via pronase predigestion and tissue pulverization Open
The isolation of high‐quality RNA from the intervertebral disc and especially from the nucleus pulposus is challenging due to the low cellularity and high proteoglycan content of this tissue. In this study, we report a simple modification …
View article: Five Days Granulocyte Colony-Stimulating Factor Treatment Increases Bone Formation and Reduces Gap Size of a Rat Segmental Bone Defect: A Pilot Study
Five Days Granulocyte Colony-Stimulating Factor Treatment Increases Bone Formation and Reduces Gap Size of a Rat Segmental Bone Defect: A Pilot Study Open
Bone is an organ with high natural regenerative capacity and most fractures heal spontaneously when appropriate fracture fixation is provided. However, additional treatment is required for patients with large segmental defects exceeding th…
View article: Correction: Corrigendum: Monitoring live human mesenchymal stromal cell differentiation and subsequent selection using fluorescent RNA-based probes
Correction: Corrigendum: Monitoring live human mesenchymal stromal cell differentiation and subsequent selection using fluorescent RNA-based probes Open
Scientific Reports 6: Article number: 26014; published online: 20 May 2016; updated: 08 November 2016 .
View article: Monitoring live human mesenchymal stromal cell differentiation and subsequent selection using fluorescent RNA-based probes
Monitoring live human mesenchymal stromal cell differentiation and subsequent selection using fluorescent RNA-based probes Open
View article: Pericyte plasticity – comparative investigation of the angiogenic and multilineage potential of pericytes from different human tissues
Pericyte plasticity – comparative investigation of the angiogenic and multilineage potential of pericytes from different human tissues Open
Pericyte recruitment is essential for the stability of newly formed vessels. It was also suggested that pericytes represent common ancestor cells giving rise to mesenchymal stem cells (MSCs) in the adult. Here, we systematically investigat…
View article: An<i>In Vitro</i>Investigation of Platelet-Rich Plasma-Gel as a Cell and Growth Factor Delivery Vehicle for Tissue Engineering
An<i>In Vitro</i>Investigation of Platelet-Rich Plasma-Gel as a Cell and Growth Factor Delivery Vehicle for Tissue Engineering Open
Platelet-rich plasma (PRP) has been used for different applications in human and veterinary medicine. Many studies have shown promising therapeutic effects of PRP; however, there are still many controversies regarding its composition, prop…