Ursula Rambold
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View article: CD30 influences germinal center B-cell dynamics and the expansion of IgG1-switched B cells
CD30 influences germinal center B-cell dynamics and the expansion of IgG1-switched B cells Open
Initially, identified as a Hodgkin lymphoma marker, CD30 was subsequently detected on a subset of human B cells within and around germinal centers (GCs). While CD30 expression is typically restricted to a few B cells, expansion of CD30-exp…
View article: A Mouse Model to Study the Pathogenesis of γ-herpesviral Infections in Germinal Center B Cells
A Mouse Model to Study the Pathogenesis of γ-herpesviral Infections in Germinal Center B Cells Open
CD30-positive germinal center (GC)-derived B cell lymphomas are frequently linked to Epstein–Barr Virus (EBV) infection. However, a suitable animal model for the investigation of the interplay between γ-herpesvirus and host cells in B cell…
View article: RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling
RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling Open
Activation of CD40-signaling contributes to the initiation, progression and drug resistance of B cell lymphomas. We contributed to this knowledge by showing that constitutive CD40-signaling in B cells induces B cell hyperplasia and finally…