Usman A. Tahir
YOU?
Author Swipe
Human plasma proteomic profile of clonal hematopoiesis Open
Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer insights into downstream clinical consequences. Here we explore these patterns in clonal hematopoiesis of indeterminate potential (CHIP), whic…
Admixture-mapping analysis reveals genetic determinants of the human plasma proteome Open
Protein profiling and genetic findings can be integrated to define the genetic architecture of the circulating proteome in chronic diseases. Most self-identified African American (AA) individuals have both African and European genetic ance…
Hematological Indices and Abnormalities in Chronic Kidney Disease and Their Associations With Disease Severity Open
Hematological indices deteriorate with advancing CKD, with anemia, thrombocytopenia, and leukocyte abnormalities showing strong associations with disease severity. Routine hematological monitoring is essential for early detection and manag…
SECTM1 Regulates Monocyte Levels and Is Associated With Incident Coronary Heart Disease Open
Proteomic profiling may provide insights into new biomarkers and pathways in coronary heart disease (CHD). We profiled ∼1,300 proteins in 1,967 Black individuals in the Jackson Heart Study and found Secreted and Transmembrane Protein 1 (SE…
Omic Risk Scores are Associated with COPD-related Traits Across Three Cohorts Open
Background Chronic obstructive pulmonary disease (COPD) exhibits marked heterogeneity in lung function decline, mortality, exacerbations, and other disease-related outcomes. Omic risk scores (ORS) estimate the cumulative contribution of om…
Homology Modeling and Structural Docking Analysis on a Human BDNF Gene by Using Computational Algorithms Open
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that interacts with TrkB and p75NTR receptors, playing a crucial role in neuronal plasticity, differentiation, and neurotransmission. The BDNF gene regulates glutamatergic and GABA…
Intervention Mapping: A Multi-stage Investigation to Control Gastrointestinal Tract Infections at Primary Level Open
Infectious diseases of the gastrointestinal (GI) tract are among the most common primary healthcare presentations, affecting 2.86 million people worldwide. These infections can include bacterial, viral, parasitic and fungal causes, and may…
Cross-Ancestry Comparison of Aptamer and Antibody Proteomics Measures Open
Measures from affinity-proteomics platforms often correlate poorly, challenging interpretation of protein associations with genetic variants (pQTL) and phenotypes. Here, we examined 2,157 proteins measured on both SomaScan 7k and Olink Exp…
Comparative Study of Post-Operative Functional Outcomes of Open Carpal tunnel Release vs. Arthroscopic Carpal tunnel Release Open
Objective: This study aimed to compare treatment modalities OCTR and ACTR in treating carpel tunnel syndrome. This study assesses the important key indicators including symptom severity, functional status, pain intensity, time of recovery,…
FDG PET/CT imaging and circulating biomarkers of inflammation in desmoplakin cardiomyopathy Open
Aims Inflammation has been implicated in the pathogenesis of desmoplakin (DSP) cardiomyopathy, and retrospective studies have described abnormal myocardial fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) …
Plasma Proteomic Determinants of Small Vessel Disease of the Brain: the Multi‐Ethnic Study of Atherosclerosis Open
Background The identification of novel blood‐based biomarkers of small vessel disease of the brain (SVD) may improve pathophysiologic understanding and inform the development of new therapeutic strategies for prevention. We evaluated plasm…
The Relationship of Duffy Gene Polymorphism with High-Sensitivity C-Reactive Protein, Mortality, and Cardiovascular Outcomes in Black Individuals Open
Background: Black adults have higher incidence of all-cause mortality and worse cardiovascular disease (CVD) outcomes when compared to other U.S. populations. The Duffy chemokine receptor is not expressed on erythrocytes in a large majorit…
The Relationship of Duffy Gene Polymorphism with High-Sensitivity C-Reactive Protein, Mortality, and Cardiovascular Outcomes in Black Individuals Open
Background: Black adults have higher incidence of all-cause mortality and worse cardiovascular disease (CVD) outcomes when compared to other U.S. populations. The Duffy chemokine receptor is not expressed on erythrocytes in a large majorit…
Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans Open
BACKGROUNDMost GWAS of plasma proteomics have focused on White individuals of European ancestry, limiting biological insight from other ancestry-enriched protein quantitative loci (pQTL).METHODSWe conducted a discovery GWAS of approximatel…
Plasma Proteomics of Exercise Blood Pressure and Incident Hypertension Open
Importance Blood pressure response during acute exercise (exercise blood pressure [EBP]) is associated with the future risk of hypertension and cardiovascular disease (CVD). Biochemical characterization of EBP could inform disease biology …
A parametric bootstrap approach for computing confidence intervals for genetic correlations with application to genetically determined protein-protein networks Open
Genetic correlation refers to the correlation between genetic determinants of a pair of traits. When using individual-level data, it is typically estimated based on a bivariate model specification where the correlation between the two vari…
Lac-Phe mediates the anti-obesity effect of metformin Open
Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. The mechanisms that mediate metformin’s effects on energy balance remain incompletely defined. Here we show that metformin is a powerful pharmacological…
Development and validation of the DOAC Score: a novel bleeding risk prediction tool for patients with atrial fibrillation Open
Background Clinicians and patients must balance the ischemic benefits and bleeding risks when deciding to anticoagulate patients with atrial fibrillation (AF). Current clinical decision tools for assessing bleeding risk have limited perfor…
A parametric bootstrap approach for computing confidence intervals for genetic correlations with application to genetically-determined protein-protein networks Open
Genetic correlation refers to the correlation between genetic determinants of a pair of traits. When using individual-level data, it is typically estimated based on a bivariate model specification where the correlation between the two vari…
Author Correction: Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations Open
Correction to: Nature Communications 10.1038/s41467-023-38800-2, published online 30 May2023 In this article, the author name Robert E. Gerszten was incorrectly written as Robert E. Gersztern. The original article has been corrected.
Development and Validation of the DOAC Score: A Novel Bleeding Risk Prediction Tool for Patients With Atrial Fibrillation on Direct-Acting Oral Anticoagulants Open
BACKGROUND: Current clinical decision tools for assessing bleeding risk in individuals with atrial fibrillation (AF) have limited performance and were developed for individuals treated with warfarin. This study develops and validates a cli…
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma Open
Although many novel gene-metabolite and gene-protein associations have been identified using high-throughput biochemical profiling, systematic studies that leverage human genetics to illuminate causal relationships between circulating prot…
The Relationship of Duffy Gene Polymorphism, High Sensitivity C-Reactive Protein, and Long-term Outcomes Open
Background Black adults have higher incidence of all-cause death and worse cardiovascular outcomes when compared to other populations. The Duffy chemokine receptor is not expressed in a large majority of Black adults and the clinical impli…
Differences in the Circulating Proteome in Individuals with versus without Sickle Cell Trait Open
Background Sickle cell trait affects approximately 8% of Black individuals in the United States, along with many other individuals with ancestry from malaria-endemic regions worldwide. While traditionally considered a benign condition, rec…
Human Plasma Proteomic Profile of Clonal Hematopoiesis Open
Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer novel insights into downstream clinical consequences. Here, we explore such patterns in clonal hematopoiesis of indeterminate potential (CHIP)…