Usha Agrawal
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View article: Geo-mapping of government healthcare facilities providing diagnostic laboratory services in Delhi, India: a pilot study
Geo-mapping of government healthcare facilities providing diagnostic laboratory services in Delhi, India: a pilot study Open
Background Despite significant advances, the Indian public diagnostic healthcare system faces serious challenges, particularly in availability and accessibility, often affecting those most in need. There is a wide urban–rural disparity, ne…
View article: The Expression of Laminin-5 in Malignant Lesions of the Oral Cavity and Its Association With the Aggressiveness of the Tumor
The Expression of Laminin-5 in Malignant Lesions of the Oral Cavity and Its Association With the Aggressiveness of the Tumor Open
Oral squamous cell carcinoma (OSCC) constitutes a major subset of head and neck cancers, with significant variability in clinical outcomes. Laminin-5, a key extracellular matrix protein involved in cell adhesion and invasion, may serve as …
View article: Bioimpedance a Diagnostic Tool for Tobacco-induced Oral Lesions – A Mixed Model Cross-sectional Study
Bioimpedance a Diagnostic Tool for Tobacco-induced Oral Lesions – A Mixed Model Cross-sectional Study Open
Introduction: Electrical impedance spectroscopy (EIS) has recently developed as a novel diagnostic device for screening and evaluating cervical dysplasia, prostate cancer, breast cancer, and basal cell carcinoma. The current study aimed to…
View article: Bioimpedance a Diagnostic Tool for Tobacco Induced Oral Lesions: a Mixed Model cross-sectional study
Bioimpedance a Diagnostic Tool for Tobacco Induced Oral Lesions: a Mixed Model cross-sectional study Open
Introduction: Electrical impedance spectroscopy (EIS) has recently developed as a novel diagnostic device for screening and evaluating cervical dysplasia, prostate cancer, breast cancer and basal cell carcinoma. The current study aimed to …
View article: Genomic landscape of gallbladder cancer: insights from whole exome sequencing
Genomic landscape of gallbladder cancer: insights from whole exome sequencing Open
Background: Gallbladder cancer (GBC) is a common gastrointestinal malignancy noted for its aggressive characteristics and poor prognosis, which is mostly caused by delayed detection. However, the scarcity of information regarding somatic m…
View article: Determination of sample size for various study designs in medical research: A practical primer
Determination of sample size for various study designs in medical research: A practical primer Open
A BSTRACT Formulating a research question and selecting an appropriate study design for answering that question are crucial initial steps in the research process. The population, intervention, control group, and outcomes measures (PICO tim…
View article: Identification of somatic mutational landscape across Indian breast cancer cases by whole exome sequencing.
Identification of somatic mutational landscape across Indian breast cancer cases by whole exome sequencing. Open
Breast cancer (BC) has emerged as the most common malignancy among females. The genomic profile of BC is diverse in nature and complex due to heterogeneity among various geographically different ethnic groups. The primary objective of this…
View article: Protein Kinase C Epsilon Overexpression in Prostate Adenocarcinoma is Associated with Oncogenesis
Protein Kinase C Epsilon Overexpression in Prostate Adenocarcinoma is Associated with Oncogenesis Open
Background: PKCε, an isozyme of serine-threonine kinase, has been implicated in epithelial cancer metastasis and progression. This study investigates the impact of the oncogenic PKCε, overexpressed abnormally in human Prostate tumor sample…
View article: Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in Breast cancer among Indian Population.
Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in Breast cancer among Indian Population. Open
Background - Breast cancer (BC) is the most common malignancy with very high incidence and relatively high mortality in women. The PIK3CA gene plays a pivotal role in the pathogenicity of breast cancer. Despite these, the mutational status…
View article: A localized hydrogel-mediated chemotherapy causes immunogenic cell death via activation of ceramide-mediated unfolded protein response
A localized hydrogel-mediated chemotherapy causes immunogenic cell death via activation of ceramide-mediated unfolded protein response Open
Treatment of triple-negative breast cancer (TNBC) is challenging because of its “COLD” tumor immunosuppressive microenvironment (TIME). Here, we present a hydrogel-mediated localized delivery of a combination of docetaxel (DTX) and carbopl…
View article: Insights from establishing a high throughput viral diagnostic laboratory for SARS-CoV-2 RT-PCR testing facility: challenges and experiences
Insights from establishing a high throughput viral diagnostic laboratory for SARS-CoV-2 RT-PCR testing facility: challenges and experiences Open
Background : The World Health Organization declared the coronavirus disease 2019 (COVID-19) a global pandemic on 11 March 2020. Identifying the infected people and isolating them was the only measure that was available to control the viral…
View article: Bioimpedance: A Tool for Screening Oral Cancer – A Systematic Review
Bioimpedance: A Tool for Screening Oral Cancer – A Systematic Review Open
Objective: The successful management of cancer depends on proper screening and treatment methods. Bioimpedance spectroscopy (BIS) is an established technique in detecting breast cancer, cervical cancer, and prostate cancer. This systematic…
View article: Enhancement of Self-Management of Metabolic Syndrome Among Adults in Urban, Low-Income Settings of India Using Digital Health Interventions: Protocol for a Mixed Methods Study
Enhancement of Self-Management of Metabolic Syndrome Among Adults in Urban, Low-Income Settings of India Using Digital Health Interventions: Protocol for a Mixed Methods Study Open
Background Metabolic syndrome (MetS) is a growing concern among adult populations in India, particularly among those living in urban, low-income settings. This group is challenged by a combination of risk factors, including an urbanized li…
View article: Protective Effects of Rifampicin and Its Analog Rifampicin Quinone in a Mouse Model of Obesity-Induced Type 2 Diabetes
Protective Effects of Rifampicin and Its Analog Rifampicin Quinone in a Mouse Model of Obesity-Induced Type 2 Diabetes Open
Advanced glycation end-products (AGEs) form when glucose reacts non-enzymatically with proteins, leading to abnormal protein function, oxidative stress, and inflammation. AGEs are associated with aging and age-related diseases; their forma…
View article: Inhibition of protein kinase C isozymes causes immune profile alteration and possibly decreased tumorigenesis in bladder cancer.
Inhibition of protein kinase C isozymes causes immune profile alteration and possibly decreased tumorigenesis in bladder cancer. Open
Protein kinase C (PRKC) isozymes activate many signaling pathways and promote tumorigenesis, which can be confirmed by masking the kinase activity. In the present study, the kinase activity of PRKC ε and ζ isozymes was masked by siRNA in b…
View article: Additional file 5 of Community—Minimal Invasive Tissue Sampling (cMITS) using a modified ambulance for ascertaining the cause of death: A novel approach piloted in a remote inaccessible rural area in India
Additional file 5 of Community—Minimal Invasive Tissue Sampling (cMITS) using a modified ambulance for ascertaining the cause of death: A novel approach piloted in a remote inaccessible rural area in India Open
Additional file 5: Annexure 5: SOP for sample storage and transport.
View article: Community - Minimal Invasive Tissue Sampling (cMITS) using modified ambulance for ascertaining cause of death: A novel approach piloted in remote inaccessible rural area in India
Community - Minimal Invasive Tissue Sampling (cMITS) using modified ambulance for ascertaining cause of death: A novel approach piloted in remote inaccessible rural area in India Open
BACKGROUND : Melghat in India is a hilly, forested, difficult to access, impoverished rural area with high mortality. Home deaths contribute to 67% of deaths, which are difficult to track and cause of death is mostly unknown. METHODS : A f…
View article: Enhancement of Self-Management of Metabolic Syndrome Among Adults in Urban, Low-Income Settings of India Using Digital Health Interventions: Protocol for a Mixed Methods Study (Preprint)
Enhancement of Self-Management of Metabolic Syndrome Among Adults in Urban, Low-Income Settings of India Using Digital Health Interventions: Protocol for a Mixed Methods Study (Preprint) Open
BACKGROUND Metabolic syndrome (MetS) is a growing concern among adult populations in India, particularly among those living in urban, low-income settings. This group is challenged by a combination of risk factors, including an urbanized l…
View article: Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors
Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors Open
Background Beta-hCG can be detected in post-menopausal women, who also demonstrate an increased cancer risk. Whether ovarian hormones mediate cytotoxic effects on beta-hCG-responsive tumor cells, whether beta-hCG exerts enhanced pro-tumori…
View article: Effect of in utero exposure to SARS-CoV-2 infection on pregnancy outcomes and growth and development of infants: protocol for a multicentre ambispective cohort study in India
Effect of in utero exposure to SARS-CoV-2 infection on pregnancy outcomes and growth and development of infants: protocol for a multicentre ambispective cohort study in India Open
Introduction Poor pregnancy and neonatal outcomes in infants born to COVID-19 positive mothers have been reported, but there is insufficient evidence regarding subsequent growth and development of these children. Our study aims to explore …
View article: Peroxiredoxins - Urinary Surveillance Biomarkers in Urothelial Cancer
Peroxiredoxins - Urinary Surveillance Biomarkers in Urothelial Cancer Open
Introduction: Urinary bladder cancer ranks the fourth most common cancer in men worldwide. Peroxiredoxins (PRDXs) are antioxidant enzymes that play an important role in cell proliferation and apoptosis. In the present study, we investigate…
View article: Proteomics analysis in urinary bladder cancer patients identifies urinary SOD2 as a predictive marker of recurrence
Proteomics analysis in urinary bladder cancer patients identifies urinary SOD2 as a predictive marker of recurrence Open
Early non-invasive detection of tumor is an urgent clinical need for managing urothelial bladder cancer. Cystoscopy and cytology are the current standards for diagnosis of recurrence, but are limited by low sensitivity. Quantitative proteo…
View article: A study to identify clinical and laboratory parameters in cases of excessive vomiting in early pregnancy
A study to identify clinical and laboratory parameters in cases of excessive vomiting in early pregnancy Open
Background: Around half of all pregnant women experience vomiting, and more than 80% of women experience nausea in the first 12 weeks. Women with severe nausea and vomiting during pregnancy may have hyperemesis gravidarum (HG), an entity d…
View article: Uterine artery Doppler analysis at 11-14 weeks as a predictor of intra-uterine growth restriction
Uterine artery Doppler analysis at 11-14 weeks as a predictor of intra-uterine growth restriction Open
Background: Successful pregnancy results from reciprocity between placental and maternal cardiovascular system. Intra-uterine growth restriction (IUGR) is a condition which arises from insufficiency of placenta and can be seen as variation…
View article: Exosomes: A Forthcoming Era of Breast Cancer Therapeutics
Exosomes: A Forthcoming Era of Breast Cancer Therapeutics Open
Despite the recent advancements in therapeutics and personalized medicine, breast cancer remains one of the most lethal cancers among women. The prognostic and diagnostic aids mainly include assessment of tumor tissues with conventional me…