J. Usha Raj
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View article: Pulmonary Hemodynamics and Long-Term Outcomes in Children with Pulmonary Hypertension-Associated Bronchopulmonary Dysplasia
Pulmonary Hemodynamics and Long-Term Outcomes in Children with Pulmonary Hypertension-Associated Bronchopulmonary Dysplasia Open
View article: Obesity‐Associated Adiposomes Promote Vascular Smooth Muscle Cell Hypercontractility
Obesity‐Associated Adiposomes Promote Vascular Smooth Muscle Cell Hypercontractility Open
Background Inter‐organ crosstalk, particularly between adipose tissue and vasculature, plays a key role in obesity‐induced cardiovascular dysfunction. Our previous work showed that adipose‐derived extracellular vesicles (adiposomes) from o…
View article: Abstract 2850 The role of APOE and GSK-3β in alzheimer's disease
Abstract 2850 The role of APOE and GSK-3β in alzheimer's disease Open
View article: An interdisciplinary consensus approach to pulmonary hypertension in developmental lung disease
An interdisciplinary consensus approach to pulmonary hypertension in developmental lung disease Open
It is increasingly recognised that diverse genetic respiratory disorders present as severe pulmonary hypertension (PH) in the neonate and young infant, but many controversies and uncertainties persist regarding optimal strategies for diagn…
View article: Life-saving effect of pulmonary surfactant in premature babies
Life-saving effect of pulmonary surfactant in premature babies Open
The discovery and replacement of lung surfactant have helped increase survival rates for neonatal respiratory distress syndrome in extremely premature infants.
View article: Biphasic regulation of miR-17∼92 transcription during hypoxia: roles of HIF1 and p53 hyperphosphorylation at ser15
Biphasic regulation of miR-17∼92 transcription during hypoxia: roles of HIF1 and p53 hyperphosphorylation at ser15 Open
We showed that the biphasic transcriptional regulation of miR-17∼92 during hypoxia is controlled by two distinct mechanisms: during short-term hypoxia exposure, induction of HIF1 and E2F1 upregulates miR-17∼92. Longer hypoxia exposure indu…
View article: Pulmonary Hypertension in Children with Down Syndrome: Results from the Pediatric Pulmonary Hypertension Network Registry
Pulmonary Hypertension in Children with Down Syndrome: Results from the Pediatric Pulmonary Hypertension Network Registry Open
View article: MicroRNA-212-5p, an anti-proliferative miRNA, attenuates hypoxia and sugen/hypoxia-induced pulmonary hypertension in rodents
MicroRNA-212-5p, an anti-proliferative miRNA, attenuates hypoxia and sugen/hypoxia-induced pulmonary hypertension in rodents Open
View article: Cardiac Catheterization and Hemodynamics in a Multicenter Cohort of Children with Pulmonary Hypertension
Cardiac Catheterization and Hemodynamics in a Multicenter Cohort of Children with Pulmonary Hypertension Open
Rationale: Hemodynamic assessments direct care among children with pulmonary hypertension, yet the use of cardiac catheterization is highly variable, which could impact patient care and research. Objectives: We analyzed hemod…
View article: Perspectives on Mental Health Evaluation in Pediatric Pulmonary Hypertension: A Call to Action
Perspectives on Mental Health Evaluation in Pediatric Pulmonary Hypertension: A Call to Action Open
Background The already high rates of anxiety and depression among healthy children have increased further since the COVID-19 pandemic began in early 2020. Prepandemic data suggest children with chronic disease were already experiencing inc…
View article: Extracellular vesicles derived from endothelial cells in hypoxia contribute to pulmonary artery smooth muscle cell proliferation in‐vitro and pulmonary hypertension in mice
Extracellular vesicles derived from endothelial cells in hypoxia contribute to pulmonary artery smooth muscle cell proliferation in‐vitro and pulmonary hypertension in mice Open
In the lung, communication between pulmonary vascular endothelial cells (PVEC) and pulmonary artery smooth muscle cells (PASMC) is essential for the maintenance of vascular homeostasis. In pulmonary hypertension (PH), the derangement in th…
View article: Characterisation of paediatric pulmonary hypertensive vascular disease from the PPHNet Registry
Characterisation of paediatric pulmonary hypertensive vascular disease from the PPHNet Registry Open
BACKGROUND: There are limited data about the range of diseases, natural history, age-appropriate end-points and optimal care for children with pulmonary hypertension (PH), including the need for developing high-quality patient registries o…
View article: Pulmonary Hypertension (PH) in Bronchopulmonary Dysplasia - The Need for Continued Outpatient Surveillance Beyond Infancy
Pulmonary Hypertension (PH) in Bronchopulmonary Dysplasia - The Need for Continued Outpatient Surveillance Beyond Infancy Open
View article: Extracellular Vesicles, MicroRNAs, and Pulmonary Hypertension
Extracellular Vesicles, MicroRNAs, and Pulmonary Hypertension Open
Pulmonary hypertension (PH) is a devastating disease that results in a progressive increase in pulmonary vascular resistance, right ventricular failure, and ultimately death of patients. Recent advances in our understanding of pathogenesis…
View article: Physiological and Biochemical Consequences of Exposure of Neonatal Rats to Chronic Hypoxia
Physiological and Biochemical Consequences of Exposure of Neonatal Rats to Chronic Hypoxia Open
We studied effect of chronic hypoxia (CH) on expression of platelet activating factor receptor (PAFR) by neonatal rats (pups). We hypothesized that PAFR antagonist will prevent pulmonary hypertension (PH) in pups exposed to CH. Pups were p…
View article: Src and Epidermal Growth Factor Receptor: Novel Partners in Mediating Chronic Hypoxia–induced Pulmonary Artery Hypertension
Src and Epidermal Growth Factor Receptor: Novel Partners in Mediating Chronic Hypoxia–induced Pulmonary Artery Hypertension Open
View article: Racial and Ethnic Differences in Pediatric Pulmonary Hypertension: An Analysis of the Pediatric Pulmonary Hypertension Network Registry
Racial and Ethnic Differences in Pediatric Pulmonary Hypertension: An Analysis of the Pediatric Pulmonary Hypertension Network Registry Open
View article: Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)–Dependent Pulmonary Arterial Hypertension
Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)–Dependent Pulmonary Arterial Hypertension Open
Objective— To determine whether pulmonary arterial hypertension is associated with endothelial cell (EC)–Cav-1 (caveolin-1) depletion, EC-derived extracellular vesicle cross talk with macrophages, and proliferation of Cav-1 depleted ECs vi…
View article: PAI-1 is a novel component of the miR-17~92 signaling that regulates pulmonary artery smooth muscle cell phenotypes
PAI-1 is a novel component of the miR-17~92 signaling that regulates pulmonary artery smooth muscle cell phenotypes Open
We have previously reported that miR-17~92 is critically involved in the pathogenesis of pulmonary hypertension (PH). We also identified two novel mR-17/20a direct targets, PDZ and LIM domain protein 5 (PDLIM5) and prolyl hydroxylase 2 (PH…
View article: Phosphatidylinositol 3‐Kinase–DNA Methyltransferase 1–miR‐1281–Histone Deacetylase 4 Regulatory Axis Mediates Platelet‐Derived Growth Factor–Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells
Phosphatidylinositol 3‐Kinase–DNA Methyltransferase 1–miR‐1281–Histone Deacetylase 4 Regulatory Axis Mediates Platelet‐Derived Growth Factor–Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells Open
Background Platelet‐derived growth factor BB , a potent mitogen of pulmonary artery smooth muscle cells ( PASMC s), has been implicated in pulmonary arterial remodeling, which is a key pathogenic feature of pulmonary arterial hypertension.…
View article: MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling
MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling Open
Pulmonary artery hypertension (PAH) is a fatal disorder. Recent studies suggest that microRNA (miRNA) plays an important role in regulating proliferation of pulmonary artery smooth muscle cells (PASMC), which underlies the pathology of PAH…
View article: Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia
Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia Open
View article: Additional file 5: Table S5. of Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia
Additional file 5: Table S5. of Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia Open
Comparison of 10 most highly differentially expressed genes between Sphk1 −/− RA and Sphk1 −/− HO groups. (XLSX 31 kb)
View article: Additional file 6: Table S6. of Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia
Additional file 6: Table S6. of Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia Open
Comparison of 10 most highly differentiated genes between WT RA and WT HO groups. (XLSX 9Â kb)
View article: Additional file 2: Table S2. of Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia
Additional file 2: Table S2. of Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia Open
Top fifty enriched pathways are listed here by cluster. The process of clustering is explained in the materials and methods. (XLSX 20Â kb)
View article: Additional file 3: Table S3. of Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia
Additional file 3: Table S3. of Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia Open
Comparison of the 10 most highly differentiated genes between WT HO and Sphk1 â /â HO groups. (XLSX 10Â kb)
View article: Additional file 4: Table S4. of Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia
Additional file 4: Table S4. of Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia Open
Comparison of the 10 most highly differentially expressed genes between WT RA and Sphk1 â /â RA groups. (XLSX 9Â kb)
View article: miR‐17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia‐Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation
miR‐17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia‐Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation Open
Background Previously we found that smooth muscle cell ( SMC )‐specific knockout of miR‐17~92 attenuates hypoxia‐induced pulmonary hypertension. However, the mechanism underlying miR‐17~92‐mediated pulmonary artery SMC ( PASMC ) proliferat…
View article: Unique Aspects of the Developing Lung Circulation: Structural Development and Regulation of Vasomotor Tone
Unique Aspects of the Developing Lung Circulation: Structural Development and Regulation of Vasomotor Tone Open
This review summarizes our current knowledge on lung vasculogenesis and angiogenesis during normal lung development and the regulation of fetal and postnatal pulmonary vascular tone. In comparison to that of the adult, the pulmonary circul…
View article: Smooth Muscle Insulin-Like Growth Factor-1 Mediates Hypoxia-Induced Pulmonary Hypertension in Neonatal Mice
Smooth Muscle Insulin-Like Growth Factor-1 Mediates Hypoxia-Induced Pulmonary Hypertension in Neonatal Mice Open
Insulin-like growth factor (IGF)-1 is a potent mitogen of vascular smooth muscle cells (SMCs), but its role in pulmonary vascular remodeling associated with pulmonary hypertension (PH) is not clear. In an earlier study, we implicated IGF-1…